Isolation and characterization of human multilineage-differentiating stress-enduring cells for use in tissue engineering: a systematic review [0.03%]
人多系分化耐受应激细胞的分离鉴定及其在组织工程中的应用系统评价
Ingrid Garzón,Miguel Ángel Martín-Piedra,Luis Martínez-Girón et al.
Ingrid Garzón et al.
Human multilineage-differentiating stress-enduring (MUSE) cells represent a promising cell population for tissue engineering and translational medicine owing to their intrinsic pluripotency and stress resistance. MUSE cells express pluripot...
Low-intensity pulsed ultrasound regulates the osteogenic-adipogenic differentiation balance of rat adipose-derived stem cells via the PI3K/AKT-SREBF1 signaling axis [0.03%]
低强度脉冲超声通过PI3K/AKT-SREBF1信号轴调节大鼠脂肪来源干细胞成骨/成脂分化平衡
Wenzhong Hu,Zhihao Zhao,Qiuling Zhang et al.
Wenzhong Hu et al.
Rat adipose-derived stem cells (rADSCs) are widely used in bone tissue engineering (BTE). Low-intensity pulsed ultrasound (LIPUS) can modulate stem cell fate; however, its precise regulatory effects on ADSC lineage commitment remain unclear...
Loss of PDL1 in mesenchymal stromal cells from young-onset MDS-RAEB-1 promotes inflamm-aging through epigenetic dysregulation of H3K9me3 [0.03%]
年轻发病MDS-RAB-1来源的间充质基质细胞中PDL1丢失通过H3K9me3表观遗传失调促进衰老相关炎症反应
Pengju Lv,Ranran Jin,Lei Sun et al.
Pengju Lv et al.
Myelodysplastic syndromes (MDS), an age-related hematological malignancy, involve dysfunctional bone marrow mesenchymal stromal cells (BM-MSCs). Our study reveals that BM-MSCs from young refractory anemia with excess of blasts-1 (RAEB-1)/MD...
Safety of intravascular administration of umbilical-cord-derived mesenchymal stromal cells: an updated systematic review and meta-analysis [0.03%]
胎盘来源间充质基质细胞静脉输注安全性：系统性回顾和meta分析更新
Christine Hum,Jessica Poliwoda,Manoj Lalu et al.
Christine Hum et al.
Background: Mesenchymal stromal cells (MSCs) have the capacity to self-renew and exert immunomodulatory and paracrine effects. Our previously published systematic review of 55 randomized controlled trials (RCTs) of all MS...
Five-year follow-up outcomes after phase 1 trial of mesenchymal stromal cells for periventricular hemorrhagic infarction in preterm infants [0.03%]
早产儿脑室周围白质损伤后进行间充质基质细胞一期临床试验5年随访结果
Misun Yang,So Yoon Ahn,Se In Sung et al.
Misun Yang et al.
Periventricular hemorrhagic infarction (PVHI), commonly referred to as grade 4 intraventricular hemorrhage, is a serious neurological disorder in premature infants with no established disease-modifying therapy. This study evaluated the long...
Imbalance in WNT: retinoic acid signaling dysregulates HOX gene expression: implications for cancer stem cell heterogeneity and CRC patient survival [0.03%]
WNT：视黄酸信号紊乱调节HOX基因表达：对癌症干细胞异质性和结直肠癌患者生存率的启示
Brian Osmond,Chi Zhang,Pascal K Kataboh et al.
Brian Osmond et al.
How HOX transcription factors play a role in the stem cell (SC) origin of cancer is unclear. Our goal is to determine how dysregulation of HOX gene expression promotes colorectal cancer (CRC) development through aberrant SC regulatory mecha...
Factors affecting outcomes of intra-articular injection of autologous, culture-expanded, adipose-derived mesenchymal stem cells in knee osteoarthritis [0.03%]
自体扩增脂肪来源的间充质干细胞膝关节腔注射治疗骨关节炎的疗效影响因素分析
Jun Bum Park,Gi-Young Jang,Kye-Youl Cho et al.
Jun Bum Park et al.
Background: This study aims to assess the outcomes of intra-articular injection of adipose-derived mesenchymal stem cells (ADMSC) in osteoarthritis (OA) of knee joint up to 3-year follow-up and evaluate possible factors r...
Observational Study
Stem cells translational medicine. 2026 May 18;15(6):szag027. DOI:10.1093/stcltm/szag027 2026
Inhibiting muscle degeneration in rotator cuff tears: integrative biologic approaches targeting regeneration, fibrosis, and metabolism [0.03%]
肩袖撕裂肌肉退变的靶向治疗：整合生物靶向肌生成、抗纤维化和改善代谢的研究
Seok Won Chung,Jong Pil Yoon,Sung-Jin Park
Seok Won Chung
Rotator cuff (RC) tears are commonly associated with progressive muscle atrophy, fatty infiltration, and fibrosis, which often persist despite successful tendon repair and remain major barriers to functional recovery and structural integrit...
Extracellular vesicles from SB431542-conditioned human adipose-derived stem cells enhance in vitro and in vivo osteogenesis via a miR-20a-5p-BAMBI-BMP/canonical Wnt signaling axis [0.03%]
SB431542条件人脂肪源性干细胞外泌体通过miR-20a-5p-BAMBI-BMP/经典Wnt信号轴促进体内外源发生
Julika Huber,Michael T Longaker,Natalina Quarto
Julika Huber
Background: Critical-sized bone defects resulting from tumors, trauma, or surgery present a significant clinical challenge due to its poor self-regenerating capabilities and limited therapeutic options. Mesenchymal stem c...