Stem cell-based therapies for neuroretinal degeneration: current landscape and future perspectives [0.03%]
基于干细胞的神经视网膜退行性病变治疗：现状与未来展望
Sarah Saietz,Filippo Locri,Helena Isla-Magrané et al.
Sarah Saietz et al.
Retinal degenerations, comprising a heterogeneous group of disorders culminating in neuroretinal dysfunction, such as inherited retinal dystrophies (IRDs) and age-related retinal degeneration, are among the leading causes of irreversible vi...
A human iPSC-derived 3D spinal cord organoid model to study radiation-induced neural injury [0.03%]
人多能干细胞来源的三维脊髓类器官模型研究放射性神经损伤
Yifei Jiang,Xubo Li,Jingguang Zeng et al.
Yifei Jiang et al.
Background: Radiation therapy remains a cornerstone in the treatment of primary and metastatic tumors; however, its efficacy is limited by the spinal cord's high sensitivity to radiation-induced injury. To better understa...
Kazuto Kimura,Masaya Tsukamoto,Kohei Shishida et al.
Kazuto Kimura et al.
Background: Red blood cell (RBC) transfusions are essential for treating various medical conditions, but global demand is difficult to meet due to a dwindling donor pool and compatibility issues. Pluripotent stem cells (P...
Inhibition of inflammation and senescence with azole compound C7 enables expansion of hematopoietic stem and progenitor cells [0.03%]
azole化合物C7通过抑制炎症和衰老促进造血干细胞和祖细胞的扩增
Ze Hui Kok,Lin Ming Lee,Kelvin Y H Liu et al.
Ze Hui Kok et al.
Human hematopoietic stem and progenitor cells (HSPCs) derived from umbilical cord blood (UCB) are often insufficient in quantity for transplantation, necessitating efforts for ex vivo expansion. We previously developed a novel azole-based s...
The role of endothelial colony forming cells in the treatment of limb ischaemia: challenges in clinical translation [0.03%]
内皮集落形成细胞在治疗四肢缺血中的作用：临床转化的挑战
Christine Ayu Lagonda,Caomhán J Lyons,Yaqiong Liu et al.
Christine Ayu Lagonda et al.
Endothelial colony forming cells (ECFCs) are emerging as a promising therapeutic option for treating various vascular and degenerative disorders. These cells, also known as endothelial progenitor cells, which play a crucial role in angiogen...
Addressing bioenergetic deficits and restoring mitochondrial health in transplanted islets using mesenchymal stem cells [0.03%]
利用间充质干细胞解决移植胰岛的生物能量缺陷并恢复线粒体健康
Rosita Primavera,Abantika Ganguly,Reza Yarani et al.
Rosita Primavera et al.
During the process of islet transplantation, islets undergo isolation and are then introduced into a new microenvironment where they need to adapt and revascularize. This transition imposes substantial stress on islets, leading to mitochond...
HO-1-modified umbilical cord MSCs alleviate pulmonary arterial hypertension by reducing inflammation and endothelial dysfunction [0.03%]
HO-1修饰的脐带间充质干细胞通过减少炎症和内皮细胞功能障碍来缓解肺动脉高压
Riken Chen,Xing Chen,Limei Liang et al.
Riken Chen et al.
Objective: To evaluate the efficacy of MSCs-HO-1 in pulmonary arterial hypertension (PAH) and explore the underlying mechanisms. Methods: ...
Co-culturing hiPSC-cardiomyocytes and cardiac fibroblasts enhances engineered heart tissue structure and function [0.03%]
人诱导多能干细胞心肌细胞与心脏纤维母细胞共培养改善工程化心肌组织的结构和功能
Yinhan Luo,Jeremy Parker,Armando Alcázar Magaña et al.
Yinhan Luo et al.
Background: Engineered heart tissues (EHTs) are widely used for cardiac disease modeling and drug screening, but their lack of multicellularity limits translational relevance. Thus, it is essential to incorporate other ca...
The mitochondria-targeting compound PTC299 enhances megakaryocyte and platelet production [0.03%]
线粒体靶向化合物PTC299可促进巨核细胞和血小板的生成
Xiaoli Wang,Meijuan Xia,Yifei Cai et al.
Xiaoli Wang et al.
Backgroud: Thrombocytopenia is a common complication of various clinical conditions, resulting from impaired megakaryocyte function, reduced platelet production, or excessive platelet destruction. Current treatments, incl...
Genomic stability of human pluripotent stem cells: advances in research and screening criteria [0.03%]
人多能干细胞的基因组稳定性：研究进展和筛选标准方面的内容
Congge Li,Manqing Long,Lifeng Xiang et al.
Congge Li et al.
Genetic and acquired genomic abnormalities pose substantial risks to human pluripotent stem cells (hPSCs), presenting a critical challenge to their safe use in both research and clinical applications. Although hPSCs possess intrinsic regula...