Impact of infectious disease outbreaks and regulatory policies on cord blood banking: a two-decade single-center analysis in Korea [0.03%]
韩国二十年单中心分析：传染病爆发和监管政策对胎盘血库的影响
Sue Shin,Nam-Hee Kim,Hye Ryun Lee et al.
Sue Shin et al.
Public cord blood (CB) banks face declining inventories worldwide, but the relative contributions of regulatory changes, declining birth rates, and infectious disease outbreaks remain unclear. We performed a retrospective analysis of 73 925...
Long-term safety of intravenous human umbilical cord blood-derived mesenchymal stem cell therapy in rheumatoid arthritis: a 5-year follow-up study [0.03%]
人脐带血间充质干细胞静脉输注治疗类风湿关节炎长期安全性观察：5年随访研究
Eun Hye Park,Min Jung Kim,Kyung-Sun Kang et al.
Eun Hye Park et al.
Background/purpose: Mesenchymal stem cell (MSC) therapy offers promise for treating autoimmune diseases due to its strong immunomodulatory effects. We investigated the long-term safety of a single intravenous injection wi...
Synergistic regulation of hDPSC-iPSCs by tetrahedral DNA nanostructures for dentin-pulp complex regeneration [0.03%]
四面体DNA纳米结构协同调控人牙髓间充质干细胞诱导的多能干细胞促进牙本质-牙髓复合体再生
Qiong Rong,Yu Guo,Tingting Wang et al.
Qiong Rong et al.
The regeneration of a functional dentin-pulp complex represents a paramount objective in regenerative endodontics. However, current strategies reliant on scaffolds and growth factors are constrained by imprecise biological signaling and ine...
Hannah A Pizzato,Deepta Bhattacharya
Hannah A Pizzato
Pluripotent stem cell (PSC)-based therapies hold the potential to unlock cures for numerous diseases, including, but not limited to, Parkinson's disease, macular degeneration, heart failure, type 1 diabetes, and cancer. Yet as protocols to ...
Histone acetylation promotes FKBP5 to increase reparative dentin formation in pulp repair [0.03%]
组蛋白乙酰化促进FKBP5增加牙髓修复中修复性牙本质的形成
Shaoying Duan,Qianqian Su,Hui Yang et al.
Shaoying Duan et al.
Importance: A well-formed dentin bridge isolates irritants and prevents bacterial penetration into the remaining pulp tissue, which is essential for pulp regeneration. The existing literature on promoting reparative denti...
Lysine methyltransferase methyltransferase-like 13 regulates bone marrow mesenchymal stem cells osteo-adipogenic differentiation and senescence in osteoporosis via the Foxa1/HES-1 axis [0.03%]
组蛋白赖氨酸甲基转移酶_like_13通过Foxa1/HES_1轴调控骨髓间充质干细胞成软骨/脂分化及衰老在骨质疏松中的作用机制研究
Ying Liu,Ao Wang,Ziwen Liu et al.
Ying Liu et al.
Purpose: Recent research indicates that the senescence of bone marrow mesenchymal stem cells (BMSCs) disrupts the osteo-adipogenic balance, a primary factor contributing to the development of osteoporosis. Our previous fi...
From elective protocols to emergency reality: rethinking adipose tissue harvesting for stromal vascular fraction applications [0.03%]
从选择性协议到紧急现实：重新考虑脂肪组织收获以应用于血管基质组分
Caroline Nonnarath,Nicolas Serratrice
Caroline Nonnarath
Background: Adipose tissue is a readily accessible source of stromal vascular fraction (SVF) and adipose-derived stem/stromal cells, widely used in regenerative medicine. Current harvesting and processing standards are de...
A Phase 1 clinical trial to evaluate the safety and tolerability of CLZ-2002 for the treatment of patients with Charcot-Marie-Tooth disease type 1 [0.03%]
评估CLZ-2002治疗I型夏科马里托 Tooth 病患者的安全性与耐受性的 I 期临床试验
Hyesun Kim,Byung-Ok Choi,Hyunju Lee et al.
Hyesun Kim et al.
Background: Charcot-Marie-Tooth disease type 1 (CMT1) is a rare, genetically diverse condition and represents the most prevalent form of inherited peripheral neuropathy, characterized by Schwann cell dysfunction resulting...
Five-year follow-up of phase II trial of autologous cord blood mononuclear cells for bronchopulmonary dysplasia prevention in very preterm infants [0.03%]
极早产婴儿自体脐带血单个核细胞预防支气管肺发育不良II期临床研究的5年随访
Zhuxiao Ren,Jiangxue Han,Qi Zhang et al.
Zhuxiao Ren et al.
Background: We previously performed a phase II clinical trial involving the intravenous infusion of autologous cord blood mononuclear cells (ACBMNCs) to prevent bronchopulmonary dysplasia in premature infants. We reported...