Functional and molecular analyses reveal impaired HSPCs in Multiple Myeloma patients post-induction [0.03%]
功能和分子分析揭示诱导治疗后多发性骨髓瘤患者的造血干细胞异常
Thanh Mai Baumhardt,Amanda Amoah,Markus Hoenicka et al.
Thanh Mai Baumhardt et al.
High-dose chemotherapy and consecutive autologous stem cell transplantation (ASCT) remain the backbone of treatment for transplant-eligible patients of Multiple Myeloma (MM). However, patients are still at high risk of relapse or treatment-...
Recent advancements in tissue dissociation techniques for cell manufacturing single-cell analysis and downstream processing [0.03%]
近期组织解离技术在细胞制造、单细胞分析及后期处理中的应用进展
Aaron Jankelow,Graça Almeida-Porada,Anthony Atala et al.
Aaron Jankelow et al.
Tissue dissociation into single-cell suspensions is a critical technique for cell therapy manufacturing, single-cell analysis, and downstream processing. The process is traditionally carried out via enzymatic and mechanical dissociation of ...
Transplantation of mesenchymal stromal cell-derived mitochondria alleviates endothelial dysfunction in pre-clinical models of acute respiratory distress syndrome [0.03%]
间充质基质细胞源性线粒体移植可缓解急性呼吸窘迫综合征的内皮功能障碍
Dayene de Assis Fernandes Caldeira,Johnatas Dutra Silva,Monique Martins Melo et al.
Dayene de Assis Fernandes Caldeira et al.
Background: Pulmonary endothelial dysfunction with increased capillary permeability is a key aspect in the pathogenesis of acute respiratory distress syndrome (ARDS). It has been demonstrated that mesenchymal stromal cell...
Fibroblast Growth Factor 2-engaged cell spheroid for stem cell therapy: role of Interleukin 8 in the immune-modulatory effectiveness in the critical limb ischemia model [0.03%]
用于干细胞治疗的FGF2参与型细胞球体：在下肢严重缺血模型中免疫调节作用中的IL8的作用
Eunyeong Kim,Yunji Joo,Jong-Wan Kim et al.
Eunyeong Kim et al.
Background: Stem cell therapy has emerged as a promising approach for treating critical limb ischemia (CLI), a condition caused by atherosclerosis that results in reduced blood flow and limb necrosis. However, the underly...
Platelets facilitate fat grafting by mitochondrial transfer and reducing oxidative stress in adipose-derived stem cells [0.03%]
血小板通过线粒体转移和减少脂肪来源干细胞的氧化应激来促进脂肪移植
Chen Ke,Kaibo Liu,Wanying Chen et al.
Chen Ke et al.
Autologous fat grafting (AFG), characterized by a broad tissue source and absence of immune rejection, is extensively utilized in plastic surgery. Despite its advantages, AFG is frequently challenged by a high rate of fat resorption and lim...
Unlocking extracellular mitochondria from bench to clinical application in stroke [0.03%]
从实验室到临床应用：细胞外线粒体在卒中治疗中的作用解锁
Gen Hamanaka,Dong-Bin Back,Ji-Hyun Park et al.
Gen Hamanaka et al.
Within the central nervous system (CNS), mitochondria serve as vital energy sources for neurons, glial cells, and vascular functions, maintaining intracellular metabolic balance. Recent studies involving cellular models, rodents, and humans...
An assessment of the functional state of endothelial colony forming cells from patients with diabetes mellitus and chronic limb threatening ischemia [0.03%]
糖尿病合并慢性下肢缺血患者内皮祖细胞功能状态评估研究
Caomhán John Lyons,Michael Creane,Nadeem Soomro et al.
Caomhán John Lyons et al.
Chronic limb threatening ischemia (CLTI) is the most severe form of peripheral vascular disease which can lead to amputation with a high associated mortality rate. Endothelial colony forming cells (ECFCs) show potential as a cell therapy to...
Extracellular vesicles from mesenchymal stromal cells: an emerging therapy for intractable neonatal disorders [0.03%]
来源于间充质基质细胞的胞外囊泡：难治性新生儿疾病的新兴疗法
Sein Hwang,Young Eun Kim,Misun Yang et al.
Sein Hwang et al.
Neonatal disorders affecting different organs are highly multifactorial and involve a complex interplay among prematurity, inflammation, oxidative stress, tissue injury, immune dysregulation, and impaired regeneration. Conditions such as hy...
Anti-fibrotic effect of human amniotic fluid stem cells in biliary epithelial-mesenchymal transition of liver ductal organoid [0.03%]
人羊水干细胞通过抑制胆管类器官上皮间质转化的抗纤维化效应
Sinobol Chusilp,Poramate Klanrit,Carol Lee et al.
Sinobol Chusilp et al.
Purpose: In biliary atresia (BA), it has been demonstrated that biliary epithelial-mesenchymal transition (EMT) of reactive ductular cells is associated with liver fibrosis. This study aimed to develop an ex vivo biliary ...
Lithium chloride-treated human umbilical cord mesenchymal stem cells-derived exsomes promote hair growth by regulating miR-146a-5p-wnt pathway [0.03%]
氯化锂处理的人脐带间充质干细胞衍生的外泌体通过调节miR-146a-5p-wnt信号通路促进毛发生长
Zhao Wang,Zeyu Chai,Xuegang Xu et al.
Zhao Wang et al.
The regulation of the hair cycle is orchestrated by a complex network of signaling pathways, and substantial evidence from extensive research indicates that exosomal miRNAs may play a pivotal role in this process. In this study, we present ...