From evidence to practice: factors influencing the implementation of cord blood treatment for cerebral palsy in the United States [0.03%]
从证据到实践：美国影响脐带血治疗脑瘫实施的因素分析
Madison C B Paton,Joanne Kurtzberg,Jessica Sun et al.
Madison C B Paton et al.
Background and aims: Cord blood infusion is an emerging treatment for cerebral palsy (CP) currently offered in the United States through clinical trials and an expanded access pathway. This study aimed to understand the b...
Functional characterization of human iPSC-derived sensory neuron processes in microfluidic cultures [0.03%]
人诱导多能干细胞来源的感觉神经元在微流控培养中的功能表征
Laura Kleckner,Omar Mossad,Anil Kumar Kalia et al.
Laura Kleckner et al.
Rodent cell culture models have long underpinned research into nociceptive signaling; however, their limited recapitulation of human nociceptor biology has created a translational gap in analgesic development. While primary human sensory ne...
Patient-specific iPSC-derived ECs identify QKI-7 as a key regulator of endothelial dysfunction and potential therapeutic target in diabetes [0.03%]
基于糖尿病患者诱导多能干细胞的血管内皮细胞模型揭示QKI-7在糖尿病血管病变中的关键作用及潜在治疗价值
Victoria A Cornelius,Jenna Fulton,Clare Donaghy et al.
Victoria A Cornelius et al.
Diabetic vascular complications remain a major cause of morbidity and mortality, yet the molecular mechanisms underlying endothelial dysfunction in diabetes remain incompletely understood. Endothelial dysfunction is a key contributor to vas...
First evidence of the circulation of induced pluripotent stem cell-derived platelets in humans [0.03%]
人诱导多能干细胞源血小板输入的首个证据
Kazumasa Takao,Yoshihiro Kumagae,Junya Kanda et al.
Kazumasa Takao et al.
Platelet products are essential for preventing and treating bleeding in patients with thrombocytopenia. However, their short shelf life and reliance on voluntary blood donations pose significant challenges to maintaining a stable supply. To...
Weekend-free and robotics-compatible protocols for high-throughput human-induced pluripotent stem cell maintenance, amplification, and differentiation [0.03%]
无周末且与机器人兼容的高通量人诱导多能干细胞维持、扩增和分化的协议
Mariam Jouni,Sakina Petiwala,Divya Desai et al.
Mariam Jouni et al.
Background: Human induced pluripotent stem cells (hiPSCs) are essential tools for disease modeling, drug testing, and regenerative medicine. These applications require differentiation of multiple cell lines in parallel, s...
Ckb-Cryab-Drp1 axis enhances BMSC osteogenic differentiation and mouse alveolar bone healing through mitochondrial fission modulation [0.03%]
CKB-CRYAB-DRP1轴通过调节线粒体分裂促进骨髓间充质干细胞成骨分化及小鼠牙周 alveolar骨缺损愈合
Mingxi Wang,Long Wang,Jingchan Wang et al.
Mingxi Wang et al.
Repairing bone defects resulting from trauma, infection, or tumor resection remains a significant challenge in clinical practice. Particularly in the oral and maxillofacial region, achieving predictable bone regeneration is especially diffi...
Insulin gene-modified 3D stem cells for enhanced islet regeneration and systemic reversal of type 1 diabetes [0.03%]
胰岛素基因修饰的三维干细胞促进胰岛再生及I型糖尿病的逆转
Qian Li,Xiao Ma,Kefei Yuan et al.
Qian Li et al.
Type 1 diabetes (T1D) is a chronic autoimmune disease characterized by the destruction of pancreatic β cells, leading to lifelong insulin dependence and an increased risk of severe complications. Three-dimensional stem cells (3D SCs) cultu...
Differential miRNA profiles in fluoride-exposed rBMSCs-EVs and the influence of miR-320-3p transfer on osteogenic differentiation [0.03%]
暴露于氟的rBMSCs来源外泌体中差异表达的miRNAs及其携带的miR-320-3p对成骨分化的抑制作用
Mingyue Yin,Jing Zhang,Na Wang et al.
Mingyue Yin et al.
Long-term excessive fluoride ingestion may lead to skeletal fluorosis, a disease characterized by unclear pathogenesis and lack of effective cure. Bone marrow mesenchymal stem cell-derived extracellular vesicles (BMSCs-EVs) exert a crucial ...
PPARβ/δ priming enhances mesenchymal stromal cell anti-apoptotic properties on chondrocytes via ANGPTL4 and improves their therapeutic effects in osteoarthritis [0.03%]
PPARβ/δ预处理通过ANGPTL4增强骨髓间充质干细胞的抗凋性及其治疗骨关节炎效果
Claudia Terraza-Aguirre,Rafael Contreras-López,Clara Bernard et al.
Claudia Terraza-Aguirre et al.
Background: Osteoarthritis (OA) is a degenerative joint disease characterized by cartilage degradation, chondrocyte apoptosis, and inflammation. Mesenchymal stromal cells (MSCs) offer therapeutic potential, but their effi...
Ghrelin and relamorelin counteract hypoglycemia in mice engrafted with congenital hyperinsulinism stem cell-derived islets [0.03%]
胃促生长素和Relamorelin对抗移植了先天性高胰岛素血症干细胞源性胰岛的小鼠的低血糖作用
Väinö Lithovius,Hossam Montaser,Jonna Saarimäki-Vire et al.
Väinö Lithovius et al.
Introduction: KATP-channel-related hyperinsulinism (KATPHI) is a rare genetic disorder of the pancreatic beta cells, manifesting as life-threatening hypoglycemia in neonates due to excessive insulin secretion. Management ...