Historical Perspectives of Parkinson's Disease: Early Clinical Descriptions and Neurological Therapies [0.03%]
帕金森病的历史回顾：早期临床描述和神经系统治疗学的发展变迁
Christopher G Goetz
Christopher G Goetz
Although components of possible Parkinson's disease can be found in earlier documents, the first clear medical description was written in 1817 by James Parkinson. In the mid-1800s, Jean-Martin Charcot was particularly influential in refinin...
Erwan Bezard,Margaux Teil,Marie-Laure Arotcarena et al.
Erwan Bezard et al.
Decades of research have identified the pathological and pathophysiological hallmarks of Parkinson's disease (PD): profound deficit in brain dopamine and other monoamines, pathological α-synuclein aggregation, synaptic and neuronal network...
Laura V Pinheiro,Pedro Costa-Pinheiro,Kathryn E Wellen
Laura V Pinheiro
Metabolic reprogramming in cancer allows cells to survive in harsh environments and sustain macromolecular biosynthesis to support proliferation. In addition, metabolites play crucial roles as signaling molecules. Metabolite fluctuations ar...
K Elaine Ritter,Adam D Durbin
K Elaine Ritter
The quest for effective cancer therapeutics has traditionally centered on targeting mutated or overexpressed oncogenic proteins. However, challenges arise in cancers with low mutational burden or when the mutated oncogene is not conventiona...
S Alice Long,Peter S Linsley
S Alice Long
Biomarkers are critical to the staging and diagnosis of type 1 diabetes (T1D). Functional biomarkers offer insights into T1D immunopathogenesis and are often revealed using "omics" approaches that integrate multiple measures to identify inv...
Virginia Gao,Carl V Crawford,Jacqueline Burré
Virginia Gao
Parkinson's disease (PD) involves both the central nervous system (CNS) and enteric nervous system (ENS), and their interaction is important for understanding both the clinical manifestations of the disease and the underlying disease pathop...
Nirakar Rajbhandari,Emily Diaz,Marcie Kritzik et al.
Nirakar Rajbhandari et al.
A majority of cancer research is focused on defining the cellular and molecular basis of cancer cells and the signals that control oncogenic transformation; as a consequence, we know very little about the dynamic behavior of cancer cells in...
Cory Abate-Shen,Katerina Politi
Cory Abate-Shen
In the nearly 50 years since the original models of cancer first hit the stage, mouse models have become a major contributor to virtually all aspects of cancer research, and these have evolved well beyond simple transgenic or xenograft mode...
Bradley T Stevens,Mark E Hatley
Bradley T Stevens
Rhabdomyosarcoma (RMS) is a pediatric embryonal solid tumor and the most common pediatric soft tissue sarcoma. The histology and transcriptome of RMS resemble skeletal muscle progenitor cells that have failed to terminally differentiate. Th...
Marcus Bosenberg
Marcus Bosenberg
The recent rise in effective immuno-oncology therapies has increased demand for experimental approaches to model anticancer immunity. A variety of mouse models have been developed and used to study cancer immunology. These include mutagen-i...