The Human Pancreas in Type 1 Diabetes: Lessons Learned from the Network of Pancreatic Organ Donors with Diabetes [0.03%]
网络糖尿病胰腺捐献者项目对I型糖尿病患者胰腺的认识
Irina Kusmartseva,Amanda Posgai,Mingder Yang et al.
Irina Kusmartseva et al.
The Network for Pancreatic Organ Donors with Diabetes (nPOD) has helped shape the contemporary understanding of type 1 diabetes (T1D) pathogenesis in humans through the procurement, distribution to scientists, and collaborative study of hum...
Diane R Bielenberg,Patricia A D&#x;Amore
Diane R Bielenberg
During development, the first blood vessels are formed by the de novo assembly of angioblasts, endothelial cell precursors, in a process called vasculogenesis. All subsequent sprouting of blood vessels from pre-existing vessels is termed an...
Advances in Islet Transplantation and the Future of Stem Cell-Derived Islets to Treat Diabetes [0.03%]
胰岛移植进展及糖尿病干细胞治疗展望
Timothy J Kieffer,Corinne A Hoesli,A M James Shapiro
Timothy J Kieffer
β-Cell replacement for type 1 diabetes (T1D) can restore normal glucose homeostasis, thereby eliminating the need for exogenous insulin and halting the progression of diabetes complications. Success in achieving insulin independence follow...
Léo Bertrand,Alexander V Chervonsky,Agnès Lehuen
Léo Bertrand
Type 1 diabetes (T1D) results from the destruction of pancreatic β cells by the immune system, to which both pancreatic β-cell dysfunction and pathological activation of the immune system contribute. This paper is focused on understanding...
Erwan Bezard,Margaux Teil,Marie-Laure Arotcarena et al.
Erwan Bezard et al.
Checkpoint Inhibitor-Induced Autoimmune Diabetes: An Autoinflammatory Disease [0.03%]
检查点抑制剂诱导的自身免疫糖尿病：一种自身炎症性疾病
Zoe Quandt,Ana Perdigoto,Mark S Anderson et al.
Zoe Quandt et al.
Immunomodulatory agents targeting immune checkpoints are now the state-of-the-art for the treatment of many cancers, but at the same time have led to autoimmune side effects, including autoimmune diabetes: immune checkpoint inhibitor-induce...
Anil Bhushan,Peter J Thompson
Anil Bhushan
Recent years have seen increased recognition for the role of β-cell stress as a contributing factor to the autoimmune destruction process that ultimately results in symptomatic type 1 diabetes (T1D). Preclinical studies have discovered a v...
Cross Talk between β Cells and Immune Cells: What We Know, What We Think We Know, and What We Should Learn [0.03%]
β细胞和免疫细胞之间的对话：我们所知、我们认为所知以及我们应该了解的内容
Fatoumata Samassa,Capucine Holtzmann,Roberto Mallone
Fatoumata Samassa
Type 1 diabetes (T1D) is a disease whose pathogenesis is driven by both immune dysregulation and β-cell dysfunction. While the specialized structure and function of β cells make them vulnerable to autoimmunity, several surface receptor/li...
Jeong A Park,Nai-Kong V Cheung
Jeong A Park
Children are surviving cancer in greater numbers than ever. Over the last 50 years, substantial advancements in pediatric cancer treatment have resulted in an 85% 5-year survival rate. Nonetheless, a notable 10%-15% of patients encounter re...
Principles in the Development of Contemporary Treatment of Childhood Malignancies: The First 75 Years [0.03%]
儿童恶性肿瘤当代治疗发展的原则：最初的七十五年
Katie A Greenzang,Stephen E Sallan
Katie A Greenzang
Over the last 75 years, pediatric cancer has gone from nearly universally fatal, to having a >80% chance of long-term survival. Below we share highlights in this 75-year history, beginning with the "birth" of chemotherapy in treating childh...