Jeong A Park,Nai-Kong V Cheung
Jeong A Park
Children are surviving cancer in greater numbers than ever. Over the last 50 years, substantial advancements in pediatric cancer treatment have resulted in an 85% 5-year survival rate. Nonetheless, a notable 10%-15% of patients encounter re...
Principles in the Development of Contemporary Treatment of Childhood Malignancies: The First 75 Years [0.03%]
儿童恶性肿瘤当代治疗发展的原则：最初的七十五年
Katie A Greenzang,Stephen E Sallan
Katie A Greenzang
Over the last 75 years, pediatric cancer has gone from nearly universally fatal, to having a >80% chance of long-term survival. Below we share highlights in this 75-year history, beginning with the "birth" of chemotherapy in treating childh...
Metabolic Reprogramming in Human Cancer Patients and Patient-Derived Models [0.03%]
人类癌症患者和患者来源模型中的代谢重构
Teresa W-M Fan,Richard M Higashi,Andrew N Lane
Teresa W-M Fan
Stable isotope-resolved metabolomics delineates reprogrammed intersecting metabolic networks in human cancers. Knowledge gained from in vivo patient studies provides the "benchmark" for cancer models to recapitulate. It is particularly diff...
Imaging Tumor Metabolism [0.03%]
肿瘤代谢影像学研究进展
Thomas Ruan,Kayvan R Keshari
Thomas Ruan
Molecular imaging-the mapping of molecular and cellular processes in vivo-has the unique capability to interrogate cancer metabolism in its spatial contexts. This work describes the usage of the two most developed modalities for imaging met...
Anya Levinson,Kevin Shannon,Benjamin J Huang
Anya Levinson
Somatic RAS mutations are among the most frequent drivers in pediatric and adult cancers. Somatic KRAS, NRAS, and HRAS mutations exhibit distinct tissue-specific predilections. Germline NF1 and RAS mutations in children with neurofibromatos...
The Chicken or the Egg Dilemma: Understanding the Interplay between the Immune System and the β Cell in Type 1 Diabetes [0.03%]
鸡生蛋还是蛋生鸡？理解1型糖尿病中免疫系统和β细胞的相互作用
Maria Skjøtt Hansen,Pravil Pokharel,Jon Piganelli et al.
Maria Skjøtt Hansen et al.
In this review, we explore the complex interplay between the immune system and pancreatic β cells in the context of type 1 diabetes (T1D). While T1D is predominantly considered a T-cell-mediated autoimmune disease, the inability of human l...
Kim Tieu,Said S Salehe,Harry J Brown
Kim Tieu
The debilitating motor symptoms of Parkinson's disease (PD) result primarily from the degenerative nigrostriatal dopaminergic pathway. To elucidate pathogenic mechanisms and evaluate therapeutic strategies for PD, numerous animal models hav...
Interactions of Fatty Acid and Cholesterol Metabolism with Cellular Stress Response Pathways in Cancer [0.03%]
脂肪酸和胆固醇代谢与细胞应激反应通路在癌症中的相互作用
Alina M Winkelkotte,Kamal Al-Shami,Adriano B Chaves-Filho et al.
Alina M Winkelkotte et al.
Lipids have essential functions as structural components of cellular membranes, as efficient energy storage molecules, and as precursors of signaling mediators. While deregulated glucose and amino acid metabolism in cancer have received sub...
David V Serreze,Jennifer R Dwyer,Jeremy J Racine
David V Serreze
Multiple rodent models have been developed to study the basis of type 1 diabetes (T1D). However, nonobese diabetic (NOD) mice and derivative strains still provide the gold standard for dissecting the basis of the autoimmune responses underl...
Sydney L Campbell,Heather R Christofk
Sydney L Campbell
Tumor cells divide rapidly and dramatically alter their metabolism to meet biosynthetic and bioenergetic needs. Through studying the aberrant metabolism of cancer cells, other contexts in which metabolism drives cell state transitions becom...