Marta Martinez-Vicente,Miquel Vila
Marta Martinez-Vicente
Autophagy is a vital cellular process responsible for the degradation of proteins, organelles, and other cellular components within lysosomes. In neurons, basal autophagy is indispensable for maintaining cellular homeostasis and protein qua...
Benjamin Morris,Alejandro Gutierrez
Benjamin Morris
Cancer is caused by mutations that drive aberrant growth, proliferation, and invasion, thus overriding regulatory mechanisms that normally link these processes to organismal needs and cellular physiology. This imposes demands for the produc...
Kosuke Funato,Viviane Tabar
Kosuke Funato
Growing evidence indicates that childhood cancer is a developmental disease and the oncogenic impact of mutations depends on spatiotemporal developmental contexts. This dependency leads to distinct molecular, genetic, and clinical character...
Heikki Hyöty,Jutta E Laiho,Suvi M Virtanen
Heikki Hyöty
The contribution of environmental factors to the pathogenesis of type 1 diabetes is considered substantial, but their identification has turned out to be challenging. Large prospective studies are crucial for reliable identification of envi...
Corrigendum: Preclinical Modeling of Pathway-Targeted Therapy of Human Lung Cancer in the Mouse [0.03%]
小鼠肺癌通路靶向治疗的临床前模型的勘误通知书
Aria Vaishnavi,Conan G Kinsey,Martin McMahon
Aria Vaishnavi
Thomas Delong,Maki Nakayama
Thomas Delong
Type 1 diabetes (T1D) is an autoimmune disease mediated by T cells destroying insulin-producing β cells. Identifying the antigenic epitopes targeted by autoreactive T cells is crucial for understanding pathogenesis, detecting biomarkers, a...
Saeed Kayhanian,Roger A Barker
Saeed Kayhanian
Parkinson's disease (PD) is a common disorder that has, as part of its core pathology, the loss of the nigral dopaminergic nerve cells that project to the striatum. Replacing this loss with dopaminergic drugs has been the mainstay of therap...
Navdeep S Chandel,Karen H Vousden,Ralph J DeBerardinis
Navdeep S Chandel
Cancer cells undergo changes in metabolism that distinguish them from non-malignant tissue. These may provide a growth advantage by promoting oncogenic signaling and redirecting intermediates to anabolic pathways that provide building block...
Kostas Vekrellis,Evangelia Emmanouilidou,Maria Xilouri et al.
Kostas Vekrellis et al.
α-Synuclein (AS) is a small presynaptic protein that is genetically, biochemically, and neuropathologically linked to Parkinson's disease (PD) and related synucleinopathies. We present here a review of the topic of this relationship, focus...
The Teplizumab Saga: The Challenge of Not Getting Lost in Clinical Translation [0.03%]
Teplizumab波折：临床转化之路何去何从
Lucienne Chatenoud,Kevan C Herold,Jean-François Bach et al.
Lucienne Chatenoud et al.
In November 2022, teplizumab became the first drug approved to delay the course of any autoimmune disease and to change the course of type 1 diabetes (T1D) since the discovery of insulin. The path to its approval took more than 30 years wit...