Monogenic Type 1 Diabetes: A High Yield Pool in Which to Discover New Mechanisms and Candidate Therapeutics for Type 1 Diabetes [0.03%]
单基因型1糖尿病：发现新的I型糖尿病发病机制和候选治疗药物的高产池
Chester E Chamberlain,Michael S German,Louis H Philipson et al.
Chester E Chamberlain et al.
Rare monogenic forms of disease provide a unique opportunity to understand novel pathways in human biology. With the rapid advances in genomics and next-generation sequencing, we now have the tools to interrogate the genomes of patients on ...
Thomas Wichmann
Thomas Wichmann
Research in the last few decades has brought us closer to an understanding of the brain circuit abnormalities that underlie parkinsonian motor signs. This article summarizes the current knowledge in this rapidly emerging field. Traditional ...
Epigenetic Therapies [0.03%]
表观遗传疗法
Wallace Bourgeois,Scott A Armstrong,Emily B Heikamp
Wallace Bourgeois
Epigenetic therapies are emerging for pediatric cancers. Due to the relatively low mutational burden in pediatric tumors, epigenetic dysregulation and differentiation blockade is a hallmark of oncogenesis in some childhood cancers. By targe...
José L Lanciego,José A Obeso
José L Lanciego
The term "basal ganglia" refers to a group of interconnected subcortical nuclei engaged in motor planning and movement initiation, executive functions, behaviors, and emotions. Dopamine released from the substantia nigra is the underlying d...
Marta Martinez-Vicente,Miquel Vila
Marta Martinez-Vicente
Autophagy is a vital cellular process responsible for the degradation of proteins, organelles, and other cellular components within lysosomes. In neurons, basal autophagy is indispensable for maintaining cellular homeostasis and protein qua...
Benjamin Morris,Alejandro Gutierrez
Benjamin Morris
Cancer is caused by mutations that drive aberrant growth, proliferation, and invasion, thus overriding regulatory mechanisms that normally link these processes to organismal needs and cellular physiology. This imposes demands for the produc...
Kosuke Funato,Viviane Tabar
Kosuke Funato
Growing evidence indicates that childhood cancer is a developmental disease and the oncogenic impact of mutations depends on spatiotemporal developmental contexts. This dependency leads to distinct molecular, genetic, and clinical character...
Heikki Hyöty,Jutta E Laiho,Suvi M Virtanen
Heikki Hyöty
The contribution of environmental factors to the pathogenesis of type 1 diabetes is considered substantial, but their identification has turned out to be challenging. Large prospective studies are crucial for reliable identification of envi...
Corrigendum: Preclinical Modeling of Pathway-Targeted Therapy of Human Lung Cancer in the Mouse [0.03%]
小鼠肺癌通路靶向治疗的临床前模型的勘误通知书
Aria Vaishnavi,Conan G Kinsey,Martin McMahon
Aria Vaishnavi
Thomas Delong,Maki Nakayama
Thomas Delong
Type 1 diabetes (T1D) is an autoimmune disease mediated by T cells destroying insulin-producing β cells. Identifying the antigenic epitopes targeted by autoreactive T cells is crucial for understanding pathogenesis, detecting biomarkers, a...