Mia J Smith,Joanne Boldison,F Susan Wong
Mia J Smith
While autoreactive T cells are known to induce β-cell death in type 1 diabetes (T1D), self-reactive B cells also play an important role in the pathogenesis of T1D. Studies have shown that individuals living with T1D have an increased frequ...
Tae Gun Kang,Benjamin Youngblood
Tae Gun Kang
Type 1 diabetes (T1D) serves as an exemplar of chronic autoimmune disease characterized by insulin deficiency due to pancreatic β-cell destruction, leading to hyperglycemia and progressive organ failure. Until recently, therapeutic efforts...
The Human Pancreas in Type 1 Diabetes: Lessons Learned from the Network of Pancreatic Organ Donors with Diabetes [0.03%]
网络糖尿病胰腺捐献者项目对I型糖尿病患者胰腺的认识
Irina Kusmartseva,Amanda Posgai,Mingder Yang et al.
Irina Kusmartseva et al.
The Network for Pancreatic Organ Donors with Diabetes (nPOD) has helped shape the contemporary understanding of type 1 diabetes (T1D) pathogenesis in humans through the procurement, distribution to scientists, and collaborative study of hum...
Diane R Bielenberg,Patricia A D&#x;Amore
Diane R Bielenberg
During development, the first blood vessels are formed by the de novo assembly of angioblasts, endothelial cell precursors, in a process called vasculogenesis. All subsequent sprouting of blood vessels from pre-existing vessels is termed an...
Advances in Islet Transplantation and the Future of Stem Cell-Derived Islets to Treat Diabetes [0.03%]
胰岛移植进展及糖尿病干细胞治疗展望
Timothy J Kieffer,Corinne A Hoesli,A M James Shapiro
Timothy J Kieffer
β-Cell replacement for type 1 diabetes (T1D) can restore normal glucose homeostasis, thereby eliminating the need for exogenous insulin and halting the progression of diabetes complications. Success in achieving insulin independence follow...
Léo Bertrand,Alexander V Chervonsky,Agnès Lehuen
Léo Bertrand
Type 1 diabetes (T1D) results from the destruction of pancreatic β cells by the immune system, to which both pancreatic β-cell dysfunction and pathological activation of the immune system contribute. This paper is focused on understanding...
Erwan Bezard,Margaux Teil,Marie-Laure Arotcarena et al.
Erwan Bezard et al.
Checkpoint Inhibitor-Induced Autoimmune Diabetes: An Autoinflammatory Disease [0.03%]
检查点抑制剂诱导的自身免疫糖尿病：一种自身炎症性疾病
Zoe Quandt,Ana Perdigoto,Mark S Anderson et al.
Zoe Quandt et al.
Immunomodulatory agents targeting immune checkpoints are now the state-of-the-art for the treatment of many cancers, but at the same time have led to autoimmune side effects, including autoimmune diabetes: immune checkpoint inhibitor-induce...
Anil Bhushan,Peter J Thompson
Anil Bhushan
Recent years have seen increased recognition for the role of β-cell stress as a contributing factor to the autoimmune destruction process that ultimately results in symptomatic type 1 diabetes (T1D). Preclinical studies have discovered a v...
Cross Talk between β Cells and Immune Cells: What We Know, What We Think We Know, and What We Should Learn [0.03%]
β细胞和免疫细胞之间的对话：我们所知、我们认为所知以及我们应该了解的内容
Fatoumata Samassa,Capucine Holtzmann,Roberto Mallone
Fatoumata Samassa
Type 1 diabetes (T1D) is a disease whose pathogenesis is driven by both immune dysregulation and β-cell dysfunction. While the specialized structure and function of β cells make them vulnerable to autoimmunity, several surface receptor/li...