Kostas Vekrellis,Evangelia Emmanouilidou,Maria Xilouri et al.
Kostas Vekrellis et al.
α-Synuclein (AS) is a small presynaptic protein that is genetically, biochemically, and neuropathologically linked to Parkinson's disease (PD) and related synucleinopathies. We present here a review of the topic of this relationship, focus...
The Teplizumab Saga: The Challenge of Not Getting Lost in Clinical Translation [0.03%]
Teplizumab波折：临床转化之路何去何从
Lucienne Chatenoud,Kevan C Herold,Jean-François Bach et al.
Lucienne Chatenoud et al.
In November 2022, teplizumab became the first drug approved to delay the course of any autoimmune disease and to change the course of type 1 diabetes (T1D) since the discovery of insulin. The path to its approval took more than 30 years wit...
Ovarian Clear Cell Carcinoma: An Endometriosis-Associated Cancer with Therapeutic Challenges [0.03%]
卵巢透明细胞癌：一种与子宫内膜异位症相关的治疗难度大的癌症
Ruby Yun-Ju Huang,Jimmy Jin-Che Lin
Ruby Yun-Ju Huang
Ovarian clear cell carcinoma (OCCC) is a histological subtype of epithelial ovarian cancer with distinct pathological features, molecular profiles, and biological functions. OCCC has high incidence rates in East Asia compared to the Western...
Zhaoqi Li,Muhammad Bin Munim,Daniel A Sharygin et al.
Zhaoqi Li et al.
Rapidly proliferating cells, including cancer cells, adapt metabolism to meet the increased energetic and biosynthetic demands of cell growth and division. Many rapidly proliferating cells exhibit increased glucose consumption and fermentat...
Walter W Chen,Michael E Pacold,David M Sabatini et al.
Walter W Chen et al.
It is increasingly appreciated that cancer cells adapt their metabolic pathways to support rapid growth and proliferation as well as survival, often even under the poor nutrient conditions that characterize some tumors. Cancer cells can als...
Autoantigen-Specific Immunotherapies for the Prevention and Treatment of Type 1 Diabetes [0.03%]
用于预防和治疗1型糖尿病的自身抗原特异性免疫疗法
Mark Peakman,Pere Santamaria
Mark Peakman
Type 1 diabetes (T1D) is driven by an immunologically complex, diverse, and self-sustaining immune response directed against tissue autoantigens, leading to loss or dysfunction of β cells. To date, the single approved immune intervention i...
Yannick D Muller,Patrick Ho,Jeffrey A Bluestone et al.
Yannick D Muller et al.
In type 1 diabetes (T1D), the immune system mistakenly attacks the pancreatic islet β cells resulting in the loss of insulin secretion. Insulin-replacement therapy developed more than a century ago provided means to manage the symptoms of ...
Ralph J DeBerardinis,Karen H Vousden,Navdeep S Chandel
Ralph J DeBerardinis
Fueled by technological and conceptual advancements over the past two decades, research in cancer metabolism has begun to answer questions dating back to the time of Otto Warburg. But, as with most fields, new discoveries lead to new questi...
Ana Westenberger,Norbert Brüggemann,Christine Klein
Ana Westenberger
The genetic architecture of Parkinson's disease (PD) comprises five autosomal dominantly inherited forms with a clinical picture overall resembling idiopathic disease (PARK-SNCA, PARK-LRRK2, PARK-VPS35, PARK-CHCHD2, and PARK-RAB32) and thre...
Kevan C Herold,Jeffrey P Krischer
Kevan C Herold
Type 1 diabetes (T1D) is a chronic autoimmune disease with a metabolic outcome. Studies over the past decades, have identified the contributions of genetics, environmental factors, and disorders of innate and adaptive immunity that collecti...