Yoshikazu Nakano,Martin Niethammer,David Eidelberg
Yoshikazu Nakano
Functional neuroimaging techniques are increasingly being used to advance the diagnosis and management of Parkinson's disease (PD). Methods such as [18F]-fluorodeoxyglucose positron emission tomography (FDG PET), resting-state functional ma...
Parallels in Canonical Developmental Signaling Pathways between Normal Development and the Tumor Microenvironment [0.03%]
正常发育和肿瘤微环境之间经典发育信号通路的相似性
Julia Segal,James Cronk,Brendan Ball et al.
Julia Segal et al.
The tumor microenvironment (TME) is comprised of both cellular and stromal elements and plays an essential role in the growth, survival, and dissemination of malignancies. The TME is an organized program that develops with a growing tumor, ...
Andrea Schietinger,Ian T McBain,Katrina M Hawley et al.
Andrea Schietinger et al.
Type 1 diabetes (T1D) is a progressive T cell-mediated autoimmune disease that results from the breakdown of tolerance mechanisms in β-cell-specific T cells. Although CD8 T cells are primarily responsible for the destruction of insulin-pro...
Amy B Hont,Catherine M Bollard
Amy B Hont
Patients with relapsed or refractory pediatric solid tumors have limited therapeutic options with little to no appreciable improvements in outcomes in over two decades. Adoptive cell therapy (ACT) is a promising, targeted option for patient...
Krithi Irmady,Serge Przedborski
Krithi Irmady
Parkinson's disease (PD) is a common neurodegenerative disorder characterized by relentlessly progressive motor and nonmotor clinical features. In this paper, we offer a comprehensive overview of progression in PD, covering the heterogeneou...
Clinical Immunologic Interventions for the Treatment of Type 1 Diabetes: Challenges, Choice, and Timing of Immunomodulators [0.03%]
临床免疫干预治疗1型糖尿病：免疫调节剂的选择与时机挑战
Danijela Tatovic,Colin Dayan
Danijela Tatovic
Replacement insulin therapy has been the mainstay of type 1 diabetes mellitus (T1D) treatment ever since its introduction into clinical care more than 100 years ago. Despite advances in delivery methods, insulin remains a challenging medica...
Type 1 Diabetes: Advances in Understanding and Treatment 100 Years after the Discovery of Insulin [0.03%]
胰岛素的发现百年以来糖尿病的研究进展及治疗突破
Jeffrey A Bluestone,Kevan C Herold,Lori Sussel
Jeffrey A Bluestone
Type 1 diabetes is an autoimmune condition in which the pancreatic β cells that produce insulin are destroyed by the body's immune system. For 100 years, diet and insulin injections have been the only effective treatment. Recent advances h...
Kayla V Hamilton,Akiko Shimamura,Jessica A Pollard
Kayla V Hamilton
Hematologic malignancies (HMs) have been increasingly recognized in association with an underlying genetic predisposition syndrome (GPS) in individuals of all ages. It is critical for hematology and oncology providers to be aware of the dia...
Vilas Menon
Vilas Menon
Within the last three decades, revolutions in genomics data generation and bioinformatics analysis techniques have profoundly impacted our understanding of the molecular mechanisms of Parkinson's disease (PD). From the description of the fi...
Joseph Lipsick
Joseph Lipsick
The p53 tumor suppressor was first identified as a cellular protein that bound to the large T antigen in SV40-transformed cells. Initially thought to be the product of an oncogene, p53 turned out to be an anticancer protein whose loss or mu...