Epigenetic Therapies [0.03%]
表观遗传疗法
Wallace Bourgeois,Scott A Armstrong,Emily B Heikamp
Wallace Bourgeois
Epigenetic therapies are emerging for pediatric cancers. Due to the relatively low mutational burden in pediatric tumors, epigenetic dysregulation and differentiation blockade is a hallmark of oncogenesis in some childhood cancers. By targe...
José L Lanciego,José A Obeso
José L Lanciego
The term "basal ganglia" refers to a group of interconnected subcortical nuclei engaged in motor planning and movement initiation, executive functions, behaviors, and emotions. Dopamine released from the substantia nigra is the underlying d...
Marta Martinez-Vicente,Miquel Vila
Marta Martinez-Vicente
Autophagy is a vital cellular process responsible for the degradation of proteins, organelles, and other cellular components within lysosomes. In neurons, basal autophagy is indispensable for maintaining cellular homeostasis and protein qua...
Benjamin Morris,Alejandro Gutierrez
Benjamin Morris
Cancer is caused by mutations that drive aberrant growth, proliferation, and invasion, thus overriding regulatory mechanisms that normally link these processes to organismal needs and cellular physiology. This imposes demands for the produc...
Kosuke Funato,Viviane Tabar
Kosuke Funato
Growing evidence indicates that childhood cancer is a developmental disease and the oncogenic impact of mutations depends on spatiotemporal developmental contexts. This dependency leads to distinct molecular, genetic, and clinical character...
Heikki Hyöty,Jutta E Laiho,Suvi M Virtanen
Heikki Hyöty
The contribution of environmental factors to the pathogenesis of type 1 diabetes is considered substantial, but their identification has turned out to be challenging. Large prospective studies are crucial for reliable identification of envi...
Corrigendum: Preclinical Modeling of Pathway-Targeted Therapy of Human Lung Cancer in the Mouse [0.03%]
小鼠肺癌通路靶向治疗的临床前模型的勘误通知书
Aria Vaishnavi,Conan G Kinsey,Martin McMahon
Aria Vaishnavi
Thomas Delong,Maki Nakayama
Thomas Delong
Type 1 diabetes (T1D) is an autoimmune disease mediated by T cells destroying insulin-producing β cells. Identifying the antigenic epitopes targeted by autoreactive T cells is crucial for understanding pathogenesis, detecting biomarkers, a...
Saeed Kayhanian,Roger A Barker
Saeed Kayhanian
Parkinson's disease (PD) is a common disorder that has, as part of its core pathology, the loss of the nigral dopaminergic nerve cells that project to the striatum. Replacing this loss with dopaminergic drugs has been the mainstay of therap...
Navdeep S Chandel,Karen H Vousden,Ralph J DeBerardinis
Navdeep S Chandel
Cancer cells undergo changes in metabolism that distinguish them from non-malignant tissue. These may provide a growth advantage by promoting oncogenic signaling and redirecting intermediates to anabolic pathways that provide building block...