Andrea Schietinger,Ian T McBain,Katrina M Hawley et al.
Andrea Schietinger et al.
Type 1 diabetes (T1D) is a progressive T cell-mediated autoimmune disease that results from the breakdown of tolerance mechanisms in β-cell-specific T cells. Although CD8 T cells are primarily responsible for the destruction of insulin-pro...
Amy B Hont,Catherine M Bollard
Amy B Hont
Patients with relapsed or refractory pediatric solid tumors have limited therapeutic options with little to no appreciable improvements in outcomes in over two decades. Adoptive cell therapy (ACT) is a promising, targeted option for patient...
Krithi Irmady,Serge Przedborski
Krithi Irmady
Parkinson's disease (PD) is a common neurodegenerative disorder characterized by relentlessly progressive motor and nonmotor clinical features. In this paper, we offer a comprehensive overview of progression in PD, covering the heterogeneou...
Clinical Immunologic Interventions for the Treatment of Type 1 Diabetes: Challenges, Choice, and Timing of Immunomodulators [0.03%]
临床免疫干预治疗1型糖尿病：免疫调节剂的选择与时机挑战
Danijela Tatovic,Colin Dayan
Danijela Tatovic
Replacement insulin therapy has been the mainstay of type 1 diabetes mellitus (T1D) treatment ever since its introduction into clinical care more than 100 years ago. Despite advances in delivery methods, insulin remains a challenging medica...
Type 1 Diabetes: Advances in Understanding and Treatment 100 Years after the Discovery of Insulin [0.03%]
胰岛素的发现百年以来糖尿病的研究进展及治疗突破
Jeffrey A Bluestone,Kevan C Herold,Lori Sussel
Jeffrey A Bluestone
Type 1 diabetes is an autoimmune condition in which the pancreatic β cells that produce insulin are destroyed by the body's immune system. For 100 years, diet and insulin injections have been the only effective treatment. Recent advances h...
Kayla V Hamilton,Akiko Shimamura,Jessica A Pollard
Kayla V Hamilton
Hematologic malignancies (HMs) have been increasingly recognized in association with an underlying genetic predisposition syndrome (GPS) in individuals of all ages. It is critical for hematology and oncology providers to be aware of the dia...
Vilas Menon
Vilas Menon
Within the last three decades, revolutions in genomics data generation and bioinformatics analysis techniques have profoundly impacted our understanding of the molecular mechanisms of Parkinson's disease (PD). From the description of the fi...
Joseph Lipsick
Joseph Lipsick
The p53 tumor suppressor was first identified as a cellular protein that bound to the large T antigen in SV40-transformed cells. Initially thought to be the product of an oncogene, p53 turned out to be an anticancer protein whose loss or mu...
Monogenic Type 1 Diabetes: A High Yield Pool in Which to Discover New Mechanisms and Candidate Therapeutics for Type 1 Diabetes [0.03%]
单基因型1糖尿病：发现新的I型糖尿病发病机制和候选治疗药物的高产池
Chester E Chamberlain,Michael S German,Louis H Philipson et al.
Chester E Chamberlain et al.
Rare monogenic forms of disease provide a unique opportunity to understand novel pathways in human biology. With the rapid advances in genomics and next-generation sequencing, we now have the tools to interrogate the genomes of patients on ...
Thomas Wichmann
Thomas Wichmann
Research in the last few decades has brought us closer to an understanding of the brain circuit abnormalities that underlie parkinsonian motor signs. This article summarizes the current knowledge in this rapidly emerging field. Traditional ...