Estela Area-Gómez,Saranna Fanning,Ulf Dettmer
Estela Area-Gómez
Mounting evidence highlights a role for lipid alterations and defects in lipid signaling in age-related neurodegenerative diseases such as Parkinson's disease (PD) and related conditions (collectively referred to as synucleinopathies). This...
Ovarian Cancer Therapy [0.03%]
卵巢癌治疗
Diana Miao,Ursula A Matulonis,Rebecca L Porter
Diana Miao
Significant advances in basic and translational research have improved our understanding of the molecular alterations and biological vulnerabilities of the different histologic subsets of epithelial ovarian cancer (EOC). This has led to cli...
Virginia Gao,Carl V Crawford,Jacqueline Burré
Virginia Gao
Dennis W Dickson
Dennis W Dickson
Parkinsonism, the clinical term for a disorder with prominent bradykinesia and variably associated extrapyramidal signs and symptoms, is virtually always accompanied by degeneration of the nigrostriatal dopaminergic system, with neuronal lo...
Robert J Hawley,Joseph P Kozlovac
Robert J Hawley
Over the past thousand years, one can observe a preponderance of evidence demonstrating the emergence and application of safety principles progressing from a crude beginning to the modern era in all human accomplishments. For more than a th...
Zebrafish Models for Drug Discovery and Therapeutic Validation against Non-Tuberculous Mycobacteria [0.03%]
斑马鱼在非结核分枝杆菌药物发现和治疗验证中的模型作用
Matt D Johansen,Claire Hamela,Yi Ding et al.
Matt D Johansen et al.
The incidence of non-tuberculous mycobacteria (NTM) is increasing globally, often surpassing the incidence of new tuberculosis (TB) cases in developed countries. Most NTM are environmental organisms; however, there are a number of opportuni...
Developmental Oncology: Principles and Therapy of Cancers of Children and Young Adults [0.03%]
发育肿瘤学：儿童及年轻成人癌症的原理与治疗
Alex Kentsis,Alejandro Gutierrez
Alex Kentsis
Children and young adults are affected by a number of different cancers. These are developmental in origin and arise, in particular, in susceptible cell types. Recent advances have led to significant progress in our understanding of the und...
Arturo Casadevall
Arturo Casadevall
The fungal kingdom includes a large set of species with pathogenic potential for humans, plants, and wildlife. Whereas threats from the fungal kingdom to agriculture are appreciated, the potential of fungi to threaten humans, animals, ecosy...
Yoshikazu Nakano,Martin Niethammer,David Eidelberg
Yoshikazu Nakano
Functional neuroimaging techniques are increasingly being used to advance the diagnosis and management of Parkinson's disease (PD). Methods such as [18F]-fluorodeoxyglucose positron emission tomography (FDG PET), resting-state functional ma...
Parallels in Canonical Developmental Signaling Pathways between Normal Development and the Tumor Microenvironment [0.03%]
正常发育和肿瘤微环境之间经典发育信号通路的相似性
Julia Segal,James Cronk,Brendan Ball et al.
Julia Segal et al.
The tumor microenvironment (TME) is comprised of both cellular and stromal elements and plays an essential role in the growth, survival, and dissemination of malignancies. The TME is an organized program that develops with a growing tumor, ...