Alexandra Lodge,Julian Agin-Liebes
Alexandra Lodge
α-Synuclein (α-syn) biomarkers show great promise as diagnostic tools for Parkinson's disease (PD). In recent years, a large body of evidence has validated their efficacy as diagnostic tools for PD and other synucleinopathies and has show...
Serge Przedborski,Stanley Fahn
Serge Przedborski
Parkinson's disease (PD), once stigmatized and hidden, is now widely acknowledged by patients and recognized by the public. Yet, fundamental questions about the disease's origins, mechanisms, and progression remain unanswered. The second ed...
Who Are the Space Invaders? Planetary Protection and the Role of Biological Interactions between Extraterrestrial and Terrestrial Biospheres [0.03%]
谁是“太空入侵者”？行星保护与地外生物圈和地球生物圈之间的生物学相互作用的作用
D E Betsy Pugel,John D Rummel
D E Betsy Pugel
Exploring our solar system and returning pieces of it to Earth is a central part of the existential quest to search for life beyond our home planet. Understanding the biosafety and biocontamination implications of landing on a planetary bod...
Joseph Lipsick
Joseph Lipsick
Dysregulation of cell growth and metabolic changes are a feature of tumorigenesis. Studies over the past 50 years have mapped the pathways that control cell growth and metabolism and revealed how these are altered in cancer. In this excerpt...
Saeed Kayhanian,Roger A Barker
Saeed Kayhanian
Since the publication of our article "Dopamine Cell-Based Replacement Therapies" (Kayhanian and Barker. 2025. Cold Spring Harb Perspect Med doi:10.1101/cshperspect.a041611), three significant studies have published results that are importan...
Eric Schon,Diana Matheoud,Serge Przedborski
Eric Schon
Mitochondria are highly dynamic organelles with complex structural features that perform several essential cellular functions, including energy production by oxidative phosphorylation, regulation of calcium and lipid homeostasis, and contro...
Suzanne R Pfeffer,Dario R Alessi
Suzanne R Pfeffer
The past 10 years have seen tremendous progress in our understanding of leucine-rich repeat kinase 2 (LRRK2) and how mutations activate the kinase and trigger downstream pathology, contributing to Parkinson's disease. A breakthrough came fr...
Wassim Elyaman
Wassim Elyaman
Adaptive immunity plays a key role in the pathogenesis of Parkinson's disease (PD) and related conditions. This paper reviews the involvement of CD4+ and CD8+ T cells in PD development as well as the effect of PD genetic susceptibility vari...
Davina B Oludipe,Xiaoqing Du,Samia Akter et al.
Davina B Oludipe et al.
Parkinson's disease (PD) is a progressive neurodegenerative disorder characterized by the loss of both dopaminergic and non-dopaminergic neurons associated with the accumulation of α-synuclein aggregates and signs of neuroinflammation. Thi...
Clinical Management of Parkinson's Disease: Features, Diagnosis, and Principles of Treatment [0.03%]
帕金森病的临床管理：特征、诊断和治疗原则
Bhavana Patel,Ashley Rawls,Tracy Tholanikunnel et al.
Bhavana Patel et al.
Parkinson's disease (PD) is a progressive, neurological syndrome that is associated with a plethora of motor and nonmotor symptoms. Recognizing prodromal symptoms and diagnosing PD early and accurately as well as employing timely management...