Marina Pavlou,Thomas A Reh
Marina Pavlou
The neural retina of mammals, like most of the rest of the central nervous system, does not regenerate new neurons after they are lost through damage or disease. The ability of nonmammalian vertebrates, like fish and amphibians, is remarkab...
Epidemiology and Risk Factors for Breast Cancer: 21st Century Advances, Gaps to Address through Interdisciplinary Science [0.03%]
21世纪的乳腺癌流行病学及危险因素：通过交叉学科研究来解决的相关缺口
Mary Beth Terry,Graham A Colditz
Mary Beth Terry
Research methods to study risk factors and prevention of breast cancer have evolved rapidly. We focus on advances from epidemiologic studies reported over the past two decades addressing scientific discoveries, as well as their clinical and...
Fariba Behbod,Jennifer H Chen,Alastair Thompson
Fariba Behbod
Due to widespread adoption of screening mammography, there has been a significant increase in new diagnoses of ductal carcinoma in situ (DCIS). However, DCIS outcomes remain unclear. A large fraction of human DCIS (>50%) may not need the mu...
Electronic Retinal Prostheses [0.03%]
电子视网膜假体
Daniel Palanker
Daniel Palanker
Retinal prostheses are a promising means for restoring sight to patients blinded by photoreceptor atrophy. They introduce visual information by electrical stimulation of the surviving inner retinal neurons. Subretinal implants target the gr...
iPSC-RPE in Retinal Degeneration: Recent Advancements and Future Perspectives [0.03%]
视网膜变性中的iPSC-RPE：最新进展和未来展望
Tadao Maeda,Masayo Takahashi
Tadao Maeda
Regenerative medicine is a great hope for patients suffering from diseases for which no effective treatment is available. With the creation of induced pluripotent stem cells (iPSCs) in 2006, research and development has accelerated expediti...
Casey J Keuthan,Sadik Karma,Donald J Zack
Casey J Keuthan
Alternative splicing is a fundamental and highly regulated post-transcriptional process that enhances transcriptome and proteome diversity. This process is particularly important in neuronal tissues, such as the retina, which exhibit some o...
X-Linked Retinoschisis [0.03%]
X连锁视网膜劈裂症
Cristy A Ku,Lisa W Wei,Paul A Sieving
Cristy A Ku
X-linked retinoschisis (XLRS) is an inherited vitreoretinal dystrophy causing visual impairment in males starting at a young age with an estimated prevalence of 1:5000 to 1:25,000. The condition was first observed in two affected brothers b...
Allison Ayala,Janet Cheetham,Todd Durham et al.
Allison Ayala et al.
Natural history studies of inherited retinal diseases (IRDs) play a critical role in the design and implementation of treatment trials. Study objectives ideally encompass (1) understanding the time course and pattern of disease progression,...
Ruth Lyck,Hideaki Nishihara,Sidar Aydin et al.
Ruth Lyck et al.
The endothelial blood-brain barrier (BBB) protects central nervous system (CNS) neurons from the changeable milieu of the bloodstream by strictly controlling the movement of molecules and immune cells between the blood and the CNS. Immune c...
Shom Goel,Sarat Chandarlapaty
Shom Goel
The steady, incremental improvements in outcomes for both early-stage and advanced breast cancer patients are, in large part, attributable to the success of novel systemic therapies. In this review, we discuss key conceptual paradigms that ...