S Jay Olshansky,Bradley Willcox,Kirk Ashburn et al.
S Jay Olshansky et al.
Forthcoming advances in geroscience will influence the health span of current and future generations and generate both challenges and opportunities for those approaching or reaching retirement ages. The resulting changes in the life course ...
Immunology of Retinitis Pigmentosa and Gene Therapy-Associated Uveitis [0.03%]
视网膜色素变性及其基因治疗相关葡萄膜炎的免疫学研究
Paul Yang,Debarshi Mustafi,Kathryn L Pepple
Paul Yang
The underlying immune state of inherited retinal degenerations (IRDs) and retinitis pigmentosa (RP) has been an emerging area of interest, wherein the consequences have never been greater given the widespread recognition of gene therapy-ass...
Mehmood Khan
Mehmood Khan
While the worldwide trend in life expectancy continues to increase slightly overall, the trend for the last few decades in developed countries is that more people are spending more years in poor health with multiple chronic comorbidities. T...
Dormancy in Breast Cancer [0.03%]
乳腺癌的休眠机制
Erica Dalla,Amulya Sreekumar,Julio A Aguirre-Ghiso et al.
Erica Dalla et al.
The pattern of delayed recurrence in a subset of breast cancer patients has long been explained by a model that incorporates a variable period of cellular or tumor mass dormancy prior to disease relapse. In this review, we critically evalua...
Leisha A Emens,Sherene Loi
Leisha A Emens
Immunotherapy, particularly agents targeting the immunoregulatory PD-1/PD-L1 axis, harnesses the power of the immune system to treat cancer, with unique potential for a durable treatment effect due to immunologic memory. The PD-1 inhibitor ...
Michael Hodin
Michael Hodin
Modern longevity transforms long-held assumptions about working, saving, investing, and spending-creating both new opportunities and new challenges for wealth management in the 21st century. To adapt to these shifts, our aging world must ev...
Emma Nolan,Yibin Kang,Ilaria Malanchi
Emma Nolan
Cancer metastasis, or the development of secondary tumors in distant tissues, accounts for the vast majority of fatalities in patients with breast cancer. Breast cancer cells show a striking proclivity to metastasize to distinct organs, spe...
Emilia A Zin,Bilge E Ozturk,Deniz Dalkara et al.
Emilia A Zin et al.
Since their discovery over 55 years ago, adeno-associated virus (AAV) vectors have become powerful tools for experimental and therapeutic in vivo gene delivery, particularly in the retina. Increasing knowledge of AAV structure and biology h...
Cara C Rada,Kanako Yuki,Jie Ding et al.
Cara C Rada et al.
The neurovascular unit is a dynamic microenvironment with tightly controlled signaling and transport coordinated by the blood-brain barrier (BBB). A properly functioning BBB allows sufficient movement of ions and macromolecules to meet the ...
The Role of the National Institute on Aging in the Development of the Field of Geroscience [0.03%]
国家衰老研究所在 geroscience领域发展中的作用
Felipe Sierra,Ronald A Kohanski
Felipe Sierra
The conceptualization of the field of geroscience, which began about 10 years ago, marks, together with the publication of "The hallmarks of aging" (see López-Otín C, Blasco MA, Partridge L, Serrano M, Kroemer G. Cell 153: 1194-1217, 2013...