How CRISPR Is Revolutionizing the Generation of New Models for Cancer Research [0.03%]
CRISPR技术革命性地推动了癌症研究新模型的建立
Francisco J Sánchez Rivera,Lukas E Dow
Francisco J Sánchez Rivera
Cancers arise through acquisition of mutations in genes that regulate core biological processes like cell proliferation and cell death. Decades of cancer research have led to the identification of genes and mutations causally involved in di...
Yunlu Xue,Constance L Cepko
Yunlu Xue
Retinitis pigmentosa is a blinding disease wherein rod photoreceptors are affected first, due to the expression of a disease gene, leading to the loss of dim light vision. In many cases, cones do not express the disease gene, yet they are a...
Klytaimnistra Kiouptsi,Giulia Pontarollo,Christoph Reinhardt
Klytaimnistra Kiouptsi
The gut microbiota is increasingly recognized as an actuating variable shaping vascular development and endothelial cell function in the intestinal mucosa but also affecting the microvasculature of remote organs. In the small intestine, col...
Taylar Hammond,Julien Sage
Taylar Hammond
Cell division is obligatory to tumor growth. However, both cancer cells and noncancer cells in tumors can be found in distinct stages of the cell cycle, which may inform the growth potential of these tumors, their propensity to metastasize,...
Comparison of Worldwide Disease Prevalence and Genetic Prevalence of Inherited Retinal Diseases and Variant Interpretation Considerations [0.03%]
全球疾病患病率和遗传性视网膜疾病的基因突变携带者筛查及变异解读注意事项的比较分析研究论文
Mor Hanany,Sapir Shalom,Tamar Ben-Yosef et al.
Mor Hanany et al.
One of the considerations in planning the development of novel therapeutic modalities is disease prevalence that is usually defined by studying large national/regional populations. Such studies are rare and might suffer from inaccuracies an...
High-Throughput Identification, Modeling, and Analysis of Cancer Driver Genes In Vivo [0.03%]
高通量识别、建模和分析体内癌症驱动基因
Yuning J Tang,Emily G Shuldiner,Saswati Karmakar et al.
Yuning J Tang et al.
The vast number of genomic and molecular alterations in cancer pose a substantial challenge to uncovering the mechanisms of tumorigenesis and identifying therapeutic targets. High-throughput functional genomic methods in genetically enginee...
Rare Epithelial Ovarian Cancers: Low Grade Serous and Mucinous Carcinomas [0.03%]
低级别浆液性和粘液性卵巢癌等罕见上皮性卵巢癌
Olivia Craig,Abhimanyu Nigam,Genevieve V Dall et al.
Olivia Craig et al.
The ovarian epithelial cancer histotypes can be divided into common and rare types. Common types include high-grade serous ovarian carcinomas and the endometriosis-associated cancers, endometrioid and clear-cell carcinomas. The less common ...
Advances in Making Cancer Mouse Models More Accessible and Informative through Non-Germline Genetic Engineering [0.03%]
通过非生殖系基因工程使癌症小鼠模型更易于获取和更具信息量的最新研究进展
Katherine C Murphy,Marcus Ruscetti
Katherine C Murphy
Genetically engineered mouse models (GEMMs) allow for modeling of spontaneous tumorigenesis within its native microenvironment in mice and have provided invaluable insights into mechanisms of tumorigenesis and therapeutic strategies to trea...
Choroideremia: Toward Regulatory Approval of Retinal Gene Therapy [0.03%]
choroideremia：视网膜基因治疗的监管审批进展
Imran H Yusuf,Robert E MacLaren
Imran H Yusuf
Choroideremia is an X-linked inherited retinal degeneration characterized by primary centripetal degeneration of the retinal pigment epithelium (RPE), with secondary degeneration of the choroid and retina. Affected individuals experience re...
Simon M Petersen-Jones,András M Komáromy
Simon M Petersen-Jones
Naturally occurring inherited retinal diseases (IRDs) in cats and dogs provide a rich source of potential models for human IRDs. In many cases, the phenotypes between the species with mutations of the homologous genes are very similar. Both...