From the Inside Out: Exposing the Roles of Urea Cycle Enzymes in Tumors and Their Micro and Macro Environments [0.03%]
由内而外：揭示尿素循环酶在肿瘤及其微环境和宏观组织中的作用
Emma Hajaj,Sabina Pozzi,Ayelet Erez
Emma Hajaj
Catabolic pathways change in anabolic diseases such as cancer to maintain metabolic homeostasis. The liver urea cycle (UC) is the main catabolic pathway for disposing excess nitrogen. Outside the liver, the UC enzymes are differentially exp...
Ahmed Mahmoud,Karuna Ganesh
Ahmed Mahmoud
Metastasis is the ultimate and often lethal stage of cancer. Metastasis occurs in three phases that may vary across individuals: First, dissemination from the primary tumor. Second, tumor dormancy at the metastatic site where micrometastati...
Naoko Sasamoto,Kevin M Elias
Naoko Sasamoto
The risk of death from ovarian cancer is highly associated with the clinical stage at diagnosis. Efforts to implement screening for ovarian cancer have been largely unsuccessful, due to the low prevalence of the disease in the general popul...
Jason R Pitarresi,Ben Z Stanger
Jason R Pitarresi
All cancers arise from normal cells whose progeny acquire the cancer-initiating mutations and epigenetic modifications leading to frank tumorigenesis. The identity of those "cells-of-origin" has historically been a source of controversy acr...
The Extraordinary Phenotypic and Genetic Variability of Retinal and Macular Degenerations: The Relevance to Therapeutic Developments [0.03%]
视网膜和黄斑变性表型和基因型的多样性及其对治疗方法的影响
Isabelle Audo,Marco Nassisi,Christina Zeitz et al.
Isabelle Audo et al.
Inherited retinal diseases (IRDs) are a clinically and genetically heterogeneous group of rare conditions leading to various degrees of visual handicap and to progressive blindness in more severe cases. Besides visual rehabilitation, educat...
Stefan Erich Spirig,Magdalena Renner
Stefan Erich Spirig
Cancer Metabolism Historical Perspectives: A Chronicle of Controversies and Consensus [0.03%]
肿瘤代谢历史回顾：争议与共识记事
Chi V Dang
Chi V Dang
A century ago, Otto Warburg's work sparked the field of cancer metabolism, which has since taken a tortuous path. As evidence accumulated over the decades, consensus views of causes of cancer emerged, whereby genetic and epigenetic oncogeni...
The Emerging Role of the Single-Cell and Spatial Tumor Microenvironment in High-Grade Serous Ovarian Cancer [0.03%]
单细胞和空间肿瘤微环境在高级别浆液性卵巢癌中的作用不容忽视
Inga-Maria Launonen,Anna Vähärautio,Anniina Färkkilä
Inga-Maria Launonen
The development of single-cell and spatial technologies has enabled a more detailed understanding of the tumor microenvironment and its role in therapy response and clinical outcome of high-grade serous ovarian cancer (HGSC). Interestingly,...
Maureen A McCall
Maureen A McCall
The pig has been used as a large animal model in biomedical research for many years and its use continues to increase because induced mutations phenocopy several inherited human diseases. In addition, they are continuous breeders, can be pr...
Considerations for Developing an Autologous Induced Pluripotent Stem Cell (iPSC)-Derived Retinal Pigment Epithelium (RPE) Replacement Therapy [0.03%]
自体诱导多能干细胞衍生视网膜色素上皮治疗的考虑因素
Devika Bose,Davide Ortolan,Mitra Farnoodian et al.
Devika Bose et al.
Cell-replacement therapies are a new class of treatments, which include induced pluripotent stem cell (iPSC)-derived tissues that aim to replace degenerated cells. iPSCs can potentially be used to generate any cell type of the body, making ...