H Raza Ali,Robert B West
H Raza Ali
Spatial findings have shaped on our understanding of breast cancer. In this review, we discuss how spatial methods, including spatial transcriptomics and proteomics and the resultant understanding of spatial relationships, have contributed ...
Organoid Cultures for the Study of Mammary Biology and Breast Cancer: The Promise and Challenges [0.03%]
类器官培养在乳腺生物学及乳腺癌研究中的前景与挑战
Senthil K Muthuswamy,Joan S Brugge
Senthil K Muthuswamy
During the last decade, biomedical research has experienced a resurgence in the use of three-dimensional culture models for studies of normal and cancer biology. This resurgence has been driven by the development of models in which primary ...
Aging and Inflammation [0.03%]
衰老与炎症
Amit Singh,Shepherd H Schurman,Arsun Bektas et al.
Amit Singh et al.
Aging can be conceptualized as the progressive disequilibrium between stochastic damage accumulation and resilience mechanisms that continuously repair that damage, which eventually cause the development of chronic disease, frailty, and dea...
The Power and Promise of Patient-Derived Xenografts of Human Breast Cancer [0.03%]
人乳腺癌患者来源异种移植瘤的潜力和价值
Michael T Lewis,Carlos Caldas
Michael T Lewis
In 2016, a group of researchers engaged in the development of patient-derived xenografts (PDXs) of human breast cancer provided a comprehensive review of the state of the field. In that review, they summarized the clinical problem that PDXs...
Mutations, Bottlenecks, and Clonal Sweeps: How Environmental Carcinogens and Genomic Changes Shape Clonal Evolution during Tumor Progression [0.03%]
环境致癌剂和基因组改变如何在肿瘤进展过程中塑造克隆进化中的突变、瓶颈和克隆席卷事件
Melissa Q Reeves,Allan Balmain
Melissa Q Reeves
The transition from a single, initiated cell to a full-blown malignant tumor involves significant genomic evolution. Exposure to carcinogens-whether directly mutagenic or not-can drive progression toward malignancy, as can stochastic acquis...
Erdem M Terzi,Richard Possemato
Erdem M Terzi
Cells require micronutrients for numerous basic functions. Among these, iron, copper, and selenium are particularly critical for redox metabolism, and their importance is heightened during oncogene-driven perturbations in cancer. In this re...
Restoration of Rod-Derived Metabolic and Redox Signaling to Prevent Blindness [0.03%]
通过恢复棒体细胞代谢和氧化还原信号传导来预防失明
Emmanuelle Clérin,Najate Aït-Ali,José-Alain Sahel et al.
Emmanuelle Clérin et al.
Vision is initiated by capturing photons in highly specialized sensory cilia known as the photoreceptor outer segment. Because of its lipid and protein composition, the outer segments are prone to photo-oxidation, requiring photoreceptors t...
Sofie Lautrup,Yujun Hou,Evandro F Fang et al.
Sofie Lautrup et al.
NAD+, the essential metabolite involved in multiple reactions such as the regulation of cellular metabolism, energy production, DNA repair, mitophagy and autophagy, inflammation, and neuronal function, has been the subject of intense resear...
Rodent Models of Retinal Degeneration: From Purified Cells in Culture to Living Animals [0.03%]
从培养的纯化细胞到活体动物的眼科退行性疾病的啮齿类模型研究
Valérie Fradot,Sébastien Augustin,Valérie Fontaine et al.
Valérie Fradot et al.
Rodent models of retinal degeneration are essential for the development of therapeutic strategies. In addition to living animal models, we here also discuss models based on rodent cell cultures, such as purified retinal ganglion cells and r...
Laure Blouin,José-Alain Sahel,Daniel C Chung
Laure Blouin
Inherited retinal diseases (IRDs) are the leading cause of blindness in working-age individuals worldwide. Their genetic etiology is especially heterogenous, so the development of gene-specific therapies is unlikely to meet the medical need...