Tracing the Diverse Paths of One-Carbon Metabolism in Cancer and Beyond [0.03%]
癌症中一碳代谢的多样化路径追溯及其影响展望
Esther W Lim,Christian M Metallo
Esther W Lim
One-carbon (1C) metabolism is a network of biochemical reactions distributed across organelles that delivers folate-activated 1C units to support macromolecule synthesis, methylation, and reductive homeostasis. Fluxes through these pathways...
Pediatric Cancer Drug Development: Leveraging Insights in Cancer Biology and the Evolving Regulatory Landscape to Address Challenges and Guide Further Progress [0.03%]
儿科癌症药物开发：利用癌症生物学的见解和不断演变的监管环境来应对挑战并进一步指导进展
Rosane Charlab,Ruby Leong,Stacy S Shord et al.
Rosane Charlab et al.
The discovery and development of anticancer drugs for pediatric patients have historically languished when compared to both past and recent activity in drug development for adult patients, notably the dramatic spike of targeted and immune-o...
Brendan D Manning,Christian C Dibble
Brendan D Manning
Normal cells grow and divide only when instructed to by signaling pathways stimulated by exogenous growth factors. A nearly ubiquitous feature of cancer cells is their capacity to grow independent of such signals, in an uncontrolled, cell-i...
Emma S Hathaway,Erin Q Jennings,Jeffrey C Rathmell
Emma S Hathaway
Tumors consist of cancer cells and a wide range of tissue resident and infiltrating cell types. Tumor metabolism, however, has largely been studied on whole tumors or cancer cells and the metabolism of infiltrating immune cells remains poor...
Jessie Yanxiang Guo,Eileen White
Jessie Yanxiang Guo
Macroautophagy (autophagy hereafter) is an intracellular nutrient scavenging pathway induced by starvation and other stressors whereby cellular components such as organelles are captured in double-membrane vesicles (autophagosomes), whereup...
Mouse Models to Evaluate the Functional Role of the Tumor Microenvironment in Cancer Progression and Therapy Responses [0.03%]
用于评估肿瘤微环境在癌症进展和治疗反应中功能作用的小鼠模型
Kathleen M McAndrews,Krishnan K Mahadevan,Raghu Kalluri
Kathleen M McAndrews
The tumor microenvironment (TME) is a complex ecosystem of both cellular and noncellular components that functions to impact the evolution of cancer. Various aspects of the TME have been targeted for the control of cancer; however, TME comp...
Isocitrate Dehydrogenase Mutations in Cancer: Mechanisms of Transformation and Metabolic Liability [0.03%]
癌症中的异柠檬酸脱氢酶突变：转化机制和代谢责任
Kathryn Gunn,Julie-Aurore Losman
Kathryn Gunn
Isocitrate dehydrogenase 1 and 2 (IDH1 and IDH2) are metabolic enzymes that interconvert isocitrate and 2-oxoglutarate (2OG). Gain-of-function mutations in IDH1 and IDH2 occur in a number of cancers, including acute myeloid leukemia, glioma...
Zuzana Kos,Torsten O Nielsen,Anne-Vibeke Laenkholm
Zuzana Kos
For more than a century, microscopic histology has been the cornerstone for cancer diagnosis, and breast carcinoma is no exception. In recent years, clinical biomarkers, gene expression profiles, and other molecular tests have shown increas...
Germline Genetic Testing for Hereditary Breast and Ovarian Cancer: Current Concepts in Risk Evaluation [0.03%]
遗传性乳腺癌和卵巢癌的种系基因检测：风险评估的新概念
Siddhartha Yadav,Fergus J Couch,Susan M Domchek
Siddhartha Yadav
Our understanding of hereditary breast and ovarian cancer has significantly improved over the past two decades. In addition to BRCA1/2, pathogenic variants in several other DNA-repair genes have been shown to increase the risks of breast an...
Caitlin S Latimer,Katherine E Prater,Nadia Postupna et al.
Caitlin S Latimer et al.
Dementia is a significant public health crisis; the most common underlying cause of age-related cognitive decline and dementia is Alzheimer's disease neuropathologic change (ADNC). As such, there is an urgent need to identify novel therapeu...