Shannon E Boye
Shannon E Boye
Leber congenital amaurosis (LCA) is a clinically and genetically heterogeneous group of diseases that account for the most severe form of early-onset retinal dystrophy. Mutations in retinal guanylate cyclase-1 (GUCY2D) are associated with L...
Richard H Shear
Richard H Shear
Patents provide an incentive to inventors, investors, and entrepreneurs to conduct research and development, especially in risky (i.e., unpredictable) fields of technology. This review discusses whether self-replicating technologies are pat...
Mouse model of tuberculosis [0.03%]
结核病小鼠模型
Andrea M Cooper
Andrea M Cooper
The mouse provides a tool with which to probe the complex interaction between the mammalian immune system and the slow-growing, inflammatory, and persistent bacterium, Mycobacterium tuberculosis (Mtb). Simple mouse models using genetic dele...
Pharmacologic considerations in use and development of antituberculosis drugs [0.03%]
抗结核病药物应用及开发中的药理学问题
Geraint Davies
Geraint Davies
Rational development and deployment of antituberculosis drugs depend on a comprehensive understanding of the pharmacokinetics and pharmacodynamics that underlie their clinical behavior. Successful implementation of a pharmacokinetic-pharmac...
Warren D Woessner,Robin A Chadwick
Warren D Woessner
The requirements for patenting inventions relating to biotechnology have become increasingly strict and complicated in recent years. Despite early patent rulings that there is no need for an inventor to "reduce to practice" an invention, th...
Ryan Wang,Janey L Wiggs
Ryan Wang
The characterization of genes responsible for glaucoma is the critical first step toward the development of gene-based diagnostic and screening tests, which could identify individuals at risk for disease before irreversible optic nerve dama...
Xiaojun Lian,Jiejia Xu,Jinsong Li et al.
Xiaojun Lian et al.
Cardiogenesis is one of the earliest and most important steps during human development and is orchestrated by discrete families of heart progenitors, which build distinct regions of the fetal heart. For the past decade, a lineage map for th...
Charles A Scanga,JoAnne L Flynn
Charles A Scanga
Nonhuman primates have emerged as an excellent model of human tuberculosis, in large part because they recapitulate the full spectrum of infection outcome and pathology seen in humans. Several variables inherent to the nonhuman primate mode...
Genome-wide association studies: getting to pathogenesis, the role of inflammation/complement in age-related macular degeneration [0.03%]
全基因组关联研究：探寻发病机制，关于炎症/补体在年龄相关性黄斑变性中的作用
Jessica N Cooke Bailey,Margaret A Pericak-Vance,Jonathan L Haines
Jessica N Cooke Bailey
Age-related macular degeneration (AMD) is a chronic, degenerative, and significant cause of visual impairment and blindness in the elderly. Genetic and epidemiological studies have confirmed that AMD has a strong genetic component, which ha...
Diversity and evolution of Mycobacterium tuberculosis: moving to whole-genome-based approaches [0.03%]
结核分枝杆菌的多样性及进化：从全基因组水平分析的角度探讨
Stefan Niemann,Philip Supply
Stefan Niemann
Genotyping of clinical Mycobacterium tuberculosis complex (MTBC) strains has become a standard tool for epidemiological tracing and for the investigation of the local and global strain population structure. Of special importance is the anal...