From Parasite to Pill: Harnessing Biology for Breakthroughs in Antimalarial Drug Discovery [0.03%]
从寄生虫到药片：利用生物学在抗疟药物发现方面的突破性进展
John G Woodland,Mariana Laureano De Souza,Ferdinand W Ndubi et al.
John G Woodland et al.
The global imperative for malaria eradication demands innovative strategies for antimalarial drug discovery, particularly in the face of growing drug resistance. This article describes how biological insights into Plasmodium parasites and t...
Malaria Parasite Genomics: Decentralization, Diversification, and Development Goals [0.03%]
疟疾寄生虫基因组学：分散化、多样化和发展目标
Alfred Amambua-Ngwa,Daniel E Neafsey,Sarah K Volkman et al.
Alfred Amambua-Ngwa et al.
The practice of malaria parasite genomics has evolved due to changing technology, expanded capacity, shifting funding, and broader applications. What began as a descriptive, discovery-focused field has grown into a global system for routine...
Ibrahim Abubakar,Jeremiah Chakaya,David Hui et al.
Ibrahim Abubakar et al.
Tuberculosis (TB) infection remains the largest reservoir sustaining the global TB epidemic and a critical target for TB elimination. Contemporary evidence has fundamentally reframed TB infection from a static latent state to a dynamic spec...
Graeme Meintjes,Bianca Sossen
Graeme Meintjes
Human immunodeficiency virus (HIV)-associated tuberculosis (TB) is a leading cause of morbidity and mortality, and HIV fuels the TB epidemic in many countries. While there is overlap, there are also critical differences in the diagnosis and...
Dermatophytes: Global Pandemic, Multidrug Resistance, Human-to-Human, and Sexual Transmission [0.03%]
皮肤丝菌：全球大流行、多重耐药性、人传人和性传播
Aditya K Gupta,Tong Wang,Anuradha Chowdhary
Aditya K Gupta
We are witnessing a sea change in the epidemiology of dermatophytosis. While commonly perceived as a mild infection of skin, hair, or nails, new human pathogens have emerged from the zoophilic Trichophyton mentagrophytes complex-Trichophyto...
The Global Epidemiology of Tuberculosis: Burden, Trends, and Determinants [0.03%]
全球结核病流行病学：负担、趋势和决定因素
Gerhard Walzl,Delia Goletti,Alimuddin Zumla
Gerhard Walzl
Tuberculosis (TB) remains the leading cause of death from an infectious disease worldwide despite availability of effective treatment. In 2024, an estimated 10.7 million people developed TB disease, including 5.8 million men, 3.7 million wo...
Diagnostic Assays for TB Disease and Drug Resistance Detection-Advances and Latest WHO Recommendations [0.03%]
结核病诊断试验及药物耐药检测的新进展和WHO最新指南建议
Paolo Miotto,Francesca Saluzzo,Andrea M Cabibbe et al.
Paolo Miotto et al.
Accurate and timely diagnosis of active tuberculosis (TB) and its drug-resistant forms are essential for effective patient care and global TB disease control. This paper summarizes the latest advances in TB disease diagnostics. We describe ...
From Empirical Discovery to Targeted Therapy: The Evolution of Tuberculosis Treatment [0.03%]
从经验发现到靶向治疗：结核病治疗的演变历程
Natalie J E Waller,Kyu Y Rhee
Natalie J E Waller
Tuberculosis (TB) chemotherapy was once considered a crowning triumph of modern medicine but has since reemerged as a persisting paradox. While therapeutically still effective in most cases, current frontline treatments for TB remain largel...
Andrea M Cooper,John E Pearl
Andrea M Cooper
The mouse provides a flexible tool to probe the interactions between the immune system and the slow growing and persistent bacterium, Mycobacterium tuberculosis (Mtb). Removal of specific cells or molecules from mice demonstrates the causal...
Jane A Shaw,Gerhard Walzl
Jane A Shaw
Host-derived biomarkers are high-priority targets for development and could play important roles in diagnosis of various states of Mycobacterium tuberculosis (Mtb) infection and disease, prediction of outcomes, and might guide vaccine and d...