Distributed Capability, Shared Vulnerability: International Governance of Biosafety and Biosecurity [0.03%]
分散的能力，相同的脆弱性：生物安全和生物保障的国际治理
Filippa Lentzos,Gemma Bowsher
Filippa Lentzos
Biological risks are increasingly shaped by globally distributed scientific capability, accelerating technological change and a rapidly evolving information environment. This review examines how these dynamics challenge traditional biosafet...
Host Cell Death Signaling Pathways Manipulated by Mycobacterium tuberculosis [0.03%]
结核分枝杆菌操控宿主细胞死亡信号通路
Guanchao Ding,Volker Briken
Guanchao Ding
Mycobacterium tuberculosis (Mtb) induces necrotic cell death of infected macrophages, which contributes to tissue necrosis and the progressive loss of lung function during tuberculosis. Mtb can induce multiple forms of programmed necrosis, ...
Delia Goletti,Alessandra Aiello,Shruthi Chandran et al.
Delia Goletti et al.
Tuberculosis (TB) continues to pose a significant global health challenge. An estimated quarter of the world's population has a TB infection (TBI) with an immune response to Mycobacterium tuberculosis (Mtb) without clinical, microbiological...
Effector Functions of Conventional and Unconventional Mycobacterium tuberculosis (Mtb)-Specific T Cells [0.03%]
结核分枝杆菌特异性经典和非经典T细胞的效应功能
Sudhasini Panda,Kendall Kearns,Cecilia S Lindestam Arlehamn
Sudhasini Panda
Effector T cells are central to immune defense against Mycobacterium tuberculosis (Mtb), exerting complex and multifaceted roles that contribute to both protection and immunopathology. CD4+ T cells activate macrophages, maintain granulomas,...
Sean Ekins,Thomas R Lane,Jason T Wong
Sean Ekins
There is an urgent need to develop additional treatments for tuberculosis (TB) to complement the small panel of approved drugs and to devise shorter treatment regimens. Within the last 20 years, we have seen an increased focus on using chem...
Pediatric Tuberculosis: Epidemiology, Disease Spectrum, Diagnosis, and Management [0.03%]
儿童结核病的流行病学、疾病谱系、诊断与管理
Ben J Marais,H Simon Schaaf
Ben J Marais
Tuberculosis (TB) is a major cause of disease and death in young children from TB-endemic countries, especially in areas affected by poverty, social disruption, and human immunodeficiency virus (HIV) infection. This article reviews the dise...
From Phagosomes to Niches: Macrophage Biology in Tuberculosis Revisited [0.03%]
从吞噬体到生态位：重新审视结核病中的巨噬细胞生物学
Pierre Dupuy,Sarah C Monard,Olivier Neyrolles et al.
Pierre Dupuy et al.
Mycobacterium tuberculosis thrives inside macrophages by modulating intracellular pathways and adapting to various lung environments. Here, we first describe how the bacillus alters phagosome maturation, endures intracellular pressure, and ...
James M Welch
James M Welch
This article is a requested personal commentary for this project based on my 20+ years of experience working nationally and globally in the advocacy of safe research and the promotion of biosafety and biosecurity. Although neither a scienti...
Oscar J Pundel,Benjamin G Neel
Oscar J Pundel
High-grade serous ovarian carcinoma (HGSC) remains an incompletely understood, highly lethal disease. Historically, a lack of fidelitous in vitro and in vivo models representing HGSC biology and therapy response has been a major barrier to ...
Valina L Dawson,Ted M Dawson
Valina L Dawson
Parkinson's disease (PD) is a complex genetic disorder that is associated with environmental risk factors and aging. Vertebrate genetic models, especially in mice, has aided the study of autosomal-dominant and autosomal-recessive PD. Mice a...