Design and Combinatorial Development of Shield-1 Peptide Mimetics Binding to Destabilized FKBP12 [0.03%]
稳定化FKBP12的Shield-1肽模拟物的设计与组合开发
Daniel Madsen,Frederik P Jørgensen,Daniel Palmer et al.
Daniel Madsen et al.
On the basis of computational design, a focused one-bead one-compound library has been prepared on microparticle-encoded PEGA1900 beads consisting of small tripeptides with a triazole-capped N-terminal. The library was screened towards a do...
Ricardo Santana,Robin Zuluaga,Piedad Gañán et al.
Ricardo Santana et al.
Determining the biological activity of vitamin derivatives is needed given that organic synthesis of analogs of vitamins is an active field of interest for medicinal chemistry, pharmaceuticals, and food additives. Accordingly, scientists fr...
Incorporation of Fluorine into an OBOC Peptide Library by Copper-Free Click Chemistry toward the Discovery of PET Imaging Agents [0.03%]
基于铜自由点击化学的氟标记寡肽文库合成及PET显像剂筛选研究
Emily Murrell,Leonard G Luyt
Emily Murrell
A one-bead one-compound (OBOC) library of peptide-based imaging agents was developed where a 19F-containing moiety was added onto the N-terminus of octamer peptides through copper-free click chemistry prior to screening of the library. This...
Aerobic Oxidation of Alcohols Catalyzed by in Situ Generated Gold Nanoparticles inside the Channels of Periodic Mesoporous Organosilica with Ionic Liquid Framework [0.03%]
一种介孔离子液体有机硅材料催化金纳米粒子原位生成并高效选择性氧化醇类化合物
Babak Karimi,Akram Bigdeli,Ali Asghar Safari et al.
Babak Karimi et al.
In situ generated gold nanoparticles inside the nanospaces of periodic mesoporous organosilica with an imidazolium framework (Au@PMO-IL) were found to be highly active, selective, and reusable catalysts for the aerobic oxidation of activate...
Antiproliferative Activities of Diimine-Based Mixed Ligand Copper(II) Complexes [0.03%]
二胺类混合配体铜（II）配合物的抗增殖活性
Nazanin Kordestani,Hadi Amiri Rudbari,Alexandra R Fernandes et al.
Nazanin Kordestani et al.
A series of Cu(diimine)(X-sal)(NO3) complexes, where the diimine is either 2,2'-bipyridine (bpy) or 1,10-phenanthroline (phen) and X-sal is a monoanionic halogenated salicylaldehyde (X = Cl, Br, I, or H), have been synthesized and character...
Homogeneous and Functional Group Tolerant Ring-Closing Metathesis for DNA-Encoded Chemical Libraries [0.03%]
用于DNA编码化合物库的均相且耐功能基团的环闭合元框反应
Olivier B C Monty,Pranavanand Nyshadham,Kurt M Bohren et al.
Olivier B C Monty et al.
Reaction heterogeneity, poor pH control, and catalyst decomposition in the ring-closing metathesis (RCM) of DNA-chemical conjugates lead to poor yields of the cyclized products. Herein we address these issues with a RCM reaction system that...
Eric P Arnold,Prolay K Mondal,Daniel C Schmitt
Eric P Arnold
An efficient approach to the parallel synthesis of benzimidazoles from anilines is described. Library approaches to vary the N1 and C2 vectors of benzimidazoles are well established; however, C4-C7 variation has traditionally relied on 1,2-...
Development of an Automatic, High-Throughput Structural Refinement Method Using Rietveld Analysis [0.03%]
基于Rietveld分析的自动、高通量结构精修方法的发展
Akihisa Aimi,Kenjiro Fujimoto
Akihisa Aimi
Automated structural analysis techniques are required to accelerate materials research. In this study, we developed an algorithm to automate Rietveld analysis, which is a method for crystal structure refinement using powder diffraction patt...
Amber L Hackler,Forrest G FitzGerald,Vuong Q Dang et al.
Amber L Hackler et al.
DNA-encoded library (DEL) technology is emerging as a key element of the small molecule discovery toolbox. Conventional DEL screens (i.e., on-DNA screening) interrogate large combinatorial libraries via affinity selection of DNA-tagged libr...
Rapid Characterization and Parameter Space Exploration of Perovskites Using an Automated Routine [0.03%]
使用自动化程序快速表征和探索钙钛矿的参数空间
Elisabeth Reinhardt,Ahmed M Salaheldin,Monica Distaso et al.
Elisabeth Reinhardt et al.
Hybrid, e.g., organic inorganic, perovskites from the type methylammonium lead iodide CH3NH3PbI3 are promising solar cell materials. However, due to the large parameter space spanned by the manifold combinations of divalent metals with orga...