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Design and Combinatorial Development of Shield-1 Peptide Mimetics Binding to Destabilized FKBP12

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On the basis of computational design, a focused one-bead one-compound library has been prepared on microparticle-encoded PEGA1900 beads consisting of small tripeptides with a triazole-capped N-terminal. The library was screened towards a double point-mutated v... ...