Polymer-Supported Syntheses of Heterocycles Bearing Oxazine and Thiazine Scaffolds [0.03%]
聚合物支撑的杂环化合物（包括噁嗪和噻嗪支架）的合成
Petra Králová,Veronika Ručilová,Miroslav Soural
Petra Králová
In this review, we summarize synthetic approaches to preparing single or fused oxazine and thiazine derivatives using solid-phase synthesis (SPS). The literature survey revealed that diverse compounds bearing variously functionalized 1,2-ox...
Development of Biphasic Formulations for Use in Electrowetting-Based Liquid Lenses with a High Refractive Index Difference [0.03%]
高折射率差电润湿液态透镜的双相体系构建研究
Matthias S Ober,Daniel Dermody,Mathieu Maillard et al.
Matthias S Ober et al.
Commercial electrowetting-based liquid lenses are optical devices containing two immiscible liquids as an optical medium. The first phase is a droplet of a high refractive index oil phase placed in a ring-shaped chassis. The second phase is...
Poly-adenine-Coupled LAMP Barcoding to Detect Apple Scar Skin Viroid [0.03%]
多腺嘌呤连接LAMP条形码技术检测苹果腐烂病病毒
Se Hee Lee,Gna Ahn,Myung-Su Kim et al.
Se Hee Lee et al.
Apple Scar Skin Viroid (ASSVd), a nonprotein coding, circular RNA pathogen is relatively difficult to detect by immunoassay. We report here a one-step reverse transcription loop-mediated isothermal amplification (RT-LAMP) assay to improve s...
Sustainable Flow Synthesis of Encoded Beads for Combinatorial Chemistry and Chemical Biology [0.03%]
可持续流编码珠组合化学和化学生物学合成
Hongxia Hu,Sergei Nikitin,Adam Bjørnholdt Berthelsen et al.
Hongxia Hu et al.
Monosized beads of polar resins were synthesized for combinatorial chemistry and chemical biology by sustainable microchannel flow synthesis. Regular, biocompatible, and optically encoded beads could be efficiently prepared on large scale a...
Synthesis of 2-Alkylsulfonyl-imidazoles with Three Diversity Positions from Immobilized α-Acylamino Ketones [0.03%]
基于固定化α-酰胺酮合成具有三个多样性位点的2-烷基磺酰基咪唑类化合物
Petra Králová,Miroslav Soural
Petra Králová
The synthesis of novel imidazole derivatives via immobilized α-acylamino ketones is reported in this article. The key intermediates were prepared from the Wang-piperazine resin-supported Fmoc-amino acids. After their sulfonylation with 4-n...
Hafeez S Haniff,Amanda Graves,Matthew D Disney
Hafeez S Haniff
Many types of RNAs exist in the human transcriptome, yet only the bacterial ribosome has been exploited as a small molecule drug target. Aside from rRNA, other cellular RNAs such as noncoding RNAs have primarily secondary structure and limi...
High-Throughput Synthesis and Characterization of Eu Doped Ba xSr2- xSiO4 Thin Film Phosphors [0.03%]
Eu掺杂的Ba x Sr2- x SiO4薄膜磷光材料的高通量制备及表征
Sara Frost,Samuel Guérin,Brian E Hayden et al.
Sara Frost et al.
High-throughput techniques have been employed for the synthesis and characterization of thin film phosphors of Eu-doped Ba xSr2- xSiO4. Direct synthesis from evaporation of the constituent elements under a flux of atomic oxygen on a sapphir...
Andrey V Bogolyubsky,Olena Savych,Anton V Zhemera et al.
Andrey V Bogolyubsky et al.
A 1,2,4-triazole motif is present in numerous commercialized and investigational bioactive molecules. Despite its importance for medicinal chemistry, there is a lack of convenient combinatorial approaches toward this molecular core. Herein,...
Remi J T Mikkelsen,Katja E Grier,Kim T Mortensen et al.
Remi J T Mikkelsen et al.
Photolabile linkers are the subjects of intense research because they allow the release of the target molecule simply by irradiation. Photochemical release of synthesis products is often facilitated without additional reagents under mild re...
Molecular Docking Analysis and Biochemical Evaluation of Levansucrase from Sphingobium chungbukense DJ77 [0.03%]
源自Sphingobium chungbukense DJ77的Levansucrase的分子对接分析及生化评估
Soo Youn Lee,Woo-Ri Shin,Simranjeet Singh Sekhon et al.
Soo Youn Lee et al.
Bacterial exopolymer Levan (β-(2,6) polyfructan) synthesized by levansucrase has attracted interest for various applications due to its low intrinsic viscosity compared with other polysaccharides. We report a novel levansucrase (Lsc) isola...