Spatially resolved in vivo ratiometric imaging of mitochondrial quality control using co-registered confocal-OCT [0.03%]
基于共聚焦-OCT的线粒体质量控制活体比率成像的时空分辨研究
Amit Hasan Sadhin,Janani Rajasekar,Taeyoon Son et al.
Amit Hasan Sadhin et al.
Mitochondrial quality control is essential for maintaining cellular bioenergetic homeostasis, but in vivo monitoring of its spatial dynamics remains difficult to quantify. Here we present a multimodal retinal imaging approach that enables s...
Multiparametric dynamic optical coherence tomography for evaluation of human cardiac organoids subjected to external stress [0.03%]
用于评估受外力作用的人类心脏器官的多参数动态光学相干层析成像技术
Nchumpeni Chonpemo Shitiri,Thanh Dat Le,Soo Ji Yoo et al.
Nchumpeni Chonpemo Shitiri et al.
Understanding how cardiac organoids respond to environmental stress is essential for advancing cardiac research and drug screening. In this study, we introduce a multiparametric dynamic optical coherence tomography (MP-DOCT) to characterize...
NIR autofluorescence allows for pituitary gland detection during surgery: evidence from microscopic studies and in vivo measurements [0.03%]
近红外自体荧光允许在手术过程中检测垂体腺：来自显微研究和体内测量的证据
Veronika Alibaeva,Nadezhda Korneva,Andrey Grigoriev et al.
Veronika Alibaeva et al.
A critical challenge in endocrine neurosurgery is intraoperative discrimination between normal pituitary tissue and pituitary neuroendocrine tumors (PitNETs). Suggesting the universal persistence of near-infrared autofluorescence (NIRAF) in...
Combination of tissue-derived and shape-based parameters for subclinical keratoconus detection [0.03%]
基于组织和形态参数的隐形角膜扩张症检测方法
Juan Casado-Moreno,Ana R Arizcuren,Jos J Rozema et al.
Juan Casado-Moreno et al.
This study investigates whether combining clinically conventional shape-based tomographic parameters and image-derived descriptors extracted from raw Scheimpflug corneal images improves the detection of subclinical keratoconus (SKC). A data...
Geometry-dependent reachability, homogenization, and redundancy in multi-view photoacoustic illumination [0.03%]
基于几何的可达性、同质化和冗余多视图光声照明
Na Cao,Hui Cao
Na Cao
In deep scattering tissue, vascular geometry strongly modulates the optical fluence field, thereby complicating quantitative photoacoustic imaging and the assessment of multi-view illumination. This study establishes a geometry-consistent b...
Spatially multiplexed random-access Raman probe for in vivo tissue measurements [0.03%]
用于体内组织测量的空间复用随机访问拉曼探针
Wataru Sakata,Atsuko Fujihara,Taisuke Ota et al.
Wataru Sakata et al.
Raman spectroscopy enables label-free identification of biological tissues, but its clinical application remains limited due to low-throughput measurements. Here, we developed a spatially multiplexed random-access Raman probe that enables s...
Towards point-of-care tests for protein detection at the attomolar level via disposable pollen-based nanoplasmonic probes grafted with polymer-based receptors [0.03%]
基于聚合物基受体的花粉纳米等离子体探针用于atto浓度水平蛋白质检测的即时检测技术研究
Rosalba Pitruzzella,Ana T Silva,Josè A Ribeiro et al.
Rosalba Pitruzzella et al.
A point-of-care test (POCT) based on low-cost and highly sensitive disposable chips was designed for the sensitive and selective detection of proteins. In particular, a pollen-based plasmonic nanostructured probe coupled, for the first time...
Compact dual-channel visible-light fluorescence endoscope for real-time molecular imaging: system design and validation in ectopic pregnancy tissue [0.03%]
一种用于实时分子影像的紧凑型双通道可见光荧光内窥镜：异位妊娠组织中的系统设计与验证
Yan Zhang,Yitian Wang,Tianyu Yu et al.
Yan Zhang et al.
Intraoperative identification of early ectopic pregnancy tissue remains challenging because chorionic villi often exhibit low visual contrast from surrounding inflamed or hemorrhagic tissue under conventional white-light endoscopy. To addre...
Histology correlated adaptive optics polarisation sensitive optical coherence tomography [0.03%]
自适应光学偏振敏感光相干断层扫描与组织学相关性研究
Thomas J Smart,Bruno Charbit,Ziqi Zhou et al.
Thomas J Smart et al.
Adaptive optics polarisation sensitive optical coherence tomography (AO-PS-OCT) provides high-resolution and tissue-specific contrast for the study of retinal pathology. We used our recently developed AO-PS-OCT system to acquire longitudina...
End-to-end hardware modeling and sensitivity optimization of photoacoustic signal readout chains [0.03%]
基于光电声信号读出链的端到端硬件仿真与灵敏度优化方法研究
Weiran Yang,Yiqi Cai,Guangyu Zeng et al.
Weiran Yang et al.
Photoacoustic imaging critically depends on the sensitivity of its acoustic readout chain, yet system-level optimization beyond the transducer remains insufficiently understood. Here, we present an end-to-end hardware model for photoacousti...