Regioselective Radical Amino-Functionalizations of Allyl Alcohols via Dual Catalytic Cross-Coupling [0.03%]
通过双重催化交叉偶联对 allyl 酒精进行有选择性的自由基氨基功能化反应
Zuxiao Zhang,Duong T Ngo,David A Nagib
Zuxiao Zhang
The regioselective amination and cross-coupling of a range of nucleophiles with allyl alcohols has been enabled by a dual catalytic strategy. This approach entails the combined action of an Ir photocatalyst that enables mild access to N-rad...
Implications for an imidazol-2-yl carbene intermediate in the rhodanase-catalyzed C-S bond formation reaction of anaerobic ergothioneine biosynthesis [0.03%]
氧杂酶催化厌氧麦角硫因生物合成中C-S键形成反应中的咪唑-2-基碳烯中间体的含义
Ronghai Cheng,Rui Lai,Chao Peng et al.
Ronghai Cheng et al.
In the anaerobic ergothioneine biosynthetic pathway, a rhodanese domain containing enzyme (EanB) activates tne hercynine's sp2 ε-C-H Dona ana replaces it with a C-S bond to produce ergothioneine. The key intermediate for this trans-sulfura...
Cationic Co(I) Catalysts for Regiodivergent Hydroalkenylation of 1,6-Enynes. An Uncommon cis-β-C-H Activation Leads to Z-Selective Coupling of Acrylates [0.03%]
用于1,6-烯炔区域发散氢烷烯基化的阳离子Co(I)催化剂。不常见的顺式-β-C-H活化导致丙烯酸酯的Z选择性偶联
James H Herbort,Remy F Lalisse,Christopher M Hadad et al.
James H Herbort et al.
Two intermolecular hydroalkenylation reactions of 1,6-enynes are presented which yield substituted 5-membered carbo- and -heterocycles. This reactivity is enabled by a cationic bis-diphenylphosphinopropane (DPPP)CoI species which forms a co...
Rh(III)-Catalyzed Three-Component Syn-Carboamination of Alkenes Using Arylboronic Acids and Dioxazolones [0.03%]
Rh(III)催化下烯烃与芳基硼酸和二氧杂环庚酮的三组分同时碳氨化反应
Sumin Lee,Tomislav Rovis
Sumin Lee
Herein we report a Rh(III)-catalyzed three-component carboamination of alkenes from readily available aryl boronic acids as a carbon source and dioxazolones as nitrogen electrophiles. This protocol provides facile access to valuable amine p...
Dissection of Alkylpyridinium Structures to Understand Deamination Reactions [0.03%]
剖析烷基吡啶𬭩结构以理解脱氨基反应
Sergei Tcyrulnikov,Qiuqi Cai,J Cameron Twitty et al.
Sergei Tcyrulnikov et al.
Via conversion to Katritzky pyridinium salts, alkyl amines can now be used as alkyl radical precursors for a range of deaminative functionalization reactions. The key step of all these methods is single electron reduction of the pyridinium ...
Sacrificial Cu Layer Mediated the Formation of an Active and Stable Supported Iridium Oxygen Evolution Reaction Electrocatalyst [0.03%]
牺牲铜层介导形成高活性和稳定的负载型铱氧析出反应电催化剂
Anja Lončar,Daniel Escalera-López,Francisco Ruiz-Zepeda et al.
Anja Lončar et al.
The production of hydrogen via a proton-exchange membrane water electrolyzer (PEM-WE) is directly dependent on the rational design of electrocatalysts for the anodic oxygen evolution reaction (OER), which is the bottleneck of the process. H...
Linear Regression Model Development for Analysis of Asymmetric Copper-Bisoxazoline Catalysis [0.03%]
线性回归模型发展用于分析不对称铜-双噁唑啉催化反应
Jacob Werth,Matthew S Sigman
Jacob Werth
Multivariate linear regression analysis (MLR) is used to unify and correlate different categories of asymmetric Cu-bisoxazoline (BOX) catalysis. The versatility of Cu-BOX complexes has been leveraged for several types of enantioselective tr...
The Stereochemical Course of Pd-Catalyzed Suzuki Reactions Using Primary Alkyltrifluoroborate Nucleophiles [0.03%]
使用 primary alkyltrifluoroborate 亲核试剂的钯催化suuzuki反应的立体化学路径研究
Benjamin Murray,Shibin Zhao,James M Aramini et al.
Benjamin Murray et al.
Using deuterium-labeled stereochemical probes, we show that primary alkyltrifluoroborate nucleophiles undergo transmetalation to palladium exclusively via a stereoretentive pathway and that the resulting stereospecificity is broadly indepen...
Isolating Conformers to Assess Dynamics of Peptidic Catalysts Using Computationally Designed Macrocyclic Peptides [0.03%]
使用计算设计的大环肽隔离构象以评估肽催化剂的动态特性
Elizabeth A Stone,Parisa Hosseinzadeh,Timothy W Craven et al.
Elizabeth A Stone et al.
Studying the relationship between catalyst conformational dynamics and selectivity in an asymmetric reaction is a challenge. In this study, cyclic peptides were computationally designed to stabilize different ground state conformations of a...
Rapid Evaluation of the Mechanism of Buchwald-Hartwig Amination and Aldol Reactions Using Intramolecular 13C Kinetic Isotope Effects [0.03%]
利用分子内13C同位素效应快速评估Buchwald-Hartwig胺化和 aldol反应的机制
Victor Wambua,Jennifer S Hirschi,Mathew J Vetticatt
Victor Wambua
A practical approach is introduced for the rapid determination of 13C kinetic isotope effects that utilizes a "designed" reactant with two identical reaction sites. The mechanism of the Buchwald-Hartwig amination of tert-butylbromobenzene w...