Understanding the Propagation Step in a Photoredox Cycloaddition Chain Reaction [0.03%]
光电红氧化加成链反应的传播步骤的理解
Annemarie A Lee,Nicole K Oo,Henry T Eaton et al.
Annemarie A Lee et al.
Photoredox catalysis has become increasingly significant in academic and industrial processes, replacing harsh reaction conditions and high temperatures with visible light. Photoredox chain reactions that proceed via dark electron or hole "...
Establishing the Fatty Acid Photodecarboxylase Cv FAP as a Platform for Photobiocatalytic Radical Transformations [0.03%]
建立脂肪酸光脱羧酶CvFAP作为光生物催化自由基转化的平台
Florian Weissensteiner,Cristina Berga,Emilia Iglesias-Moncayo et al.
Florian Weissensteiner et al.
The fatty acid photodecarboxylase from Chlorella variabilis (CvFAP) has emerged as a versatile photoenzyme for radical generation from readily available carboxylic acids. Here, we demonstrate that CvFAP can be repurposed as a platform for d...
Controllable Multihalogenation of a Non-native Substrate by the SyrB2 Iron Halogenase [0.03%]
由SyrB2铁卤素酶控制的非底物多卤化作用
R Hunter Wilson,Sourav Chatterjee,Elizabeth R Smithwick et al.
R Hunter Wilson et al.
Geminal, multihalogenated functional groups are widespread in natural products and pharmaceuticals, yet no synthetic methodologies exist that enable selective multihalogenation of unactivated C-H bonds. Biocatalysts are powerful tools for l...
Synthesis of Unsymmetrical Carbazoles: A Mechanistic Cautionary Tale When Using ortho-Borylaryl Triflates in Catalysis [0.03%]
不对称咔唑的合成：使用邻硼基芳基三氟苯磺酸盐催化时的机理警示故事
Brylon N Denman,Douglas M Kavaguti,Courtney C Roberts
Brylon N Denman
Carbazoles are desirable products with ample usage in the fields of pharmaceutical and materials chemistry. Usual methods for their synthesis often focus on the formation of a single C-C or C-N bond from complex diphenylamine- or biphenyl-d...
The Role of the Unusual 2-Tyr-1-carboxylate Non-heme Iron Motif in the Mechanism of N,N-Dimethylformamidase [0.03%]
关于N，N-二甲基甲酰胺酶机制中罕见的含铁辅因子2-Tyr-1-Carboxylate非血红素铁活性中心作用的研究
David W Kastner,Clorice R Reinhardt,Husain Adamji et al.
David W Kastner et al.
N,N-dimethylformamidase (DMFase) is a non-heme iron enzyme that catalyzes the hydrolysis of N,N-dimethylformamide (DMF) using a noncanonical Fe(III)-2Tyr-1Glu coordination motif. The precise role that this nonconventional active site plays ...
Enantioselective Synthesis of Complex Carbocycles by C-H Insertion of Aryl/Aryl Carbenes [0.03%]
基于芳基/芳基卡宾的C-H插入反应的复杂碳环化合物的不对称合成
Jose M Ruiz,Dylan R Turner,Mingchun Gao et al.
Jose M Ruiz et al.
A range of benzene and indole-fused carbocyclic molecules were accessed by the enantioselective C-H insertion of rhodium aryl/aryl carbenes. 1,4, 1,5, and 1,6 C-H insertion reactions are chemoselective for insertion into carbon centers appe...
Evaluation of Steric and Electronic Parameters of NHCs on Vanadium Imido Alkylidenes for Olefin Metathesis [0.03%]
评估N-杂环卡宾的立体和电子参数对钒亚胺基烯烃 olefin metathesis反应的影响
Samuel Aguero,Vasilisa Krivovicheva,Madhu Sudhana Reddy Gangireddy et al.
Samuel Aguero et al.
Among the first-row transition metals, vanadium stands out as a promising candidate for mediating olefin metathesis. Recent studies have shown that introducing electron-donating neutral ligands, such as N-heterocyclic carbenes (NHCs), signi...
Dynamic CO Electrolysis to Methanol on Pt(111) Surfaces Modified with a Pd Monolayer [0.03%]
单层Pd改性的Pt(111)表面上CO动态电解制甲醇
Aleksandra Wawrzyniak,Mark Aarts,Marc T M Koper
Aleksandra Wawrzyniak
In this study, we focus on improving the activity of electrochemical carbon monoxide (CO) reduction toward methanol (CH3OH) on a model catalyst reported previously by our group: a platinum(111) single crystal modified with a palladium monol...
Elizabeth J Gross,Sophia G Barthel,Carter U Brzezinski et al.
Elizabeth J Gross et al.
Organic chloramines are an important class of compounds containing a covalent nitrogen-chlorine bond. Despite the growing interest in their applications in small molecule synthesis and polymer science, selective catalyst systems for their p...
The Discovery of N 2, N 2‑Dimethylguanine Hydrolases Unravels General Molecular Principles of Enzyme Evolvability and Promiscuity [0.03%]
N2,N2-二甲基鸟嘌呤水解酶的发现揭示了酶进化和兼并性的一般分子原理
Lukas Drexler,Cristina Duran,Sílvia Osuna et al.
Lukas Drexler et al.
The widespread use of xenobiotics has driven the rapid emergence of microbial degradation pathways. A prominent example is enzymes involved in the catabolism of the herbicide atrazine, which have evolved within the last few decades. Recentl...