Elucidation of the stereochemical mechanism of cystathionine γ-lyase reveals how substrate specificity constrains catalysis [0.03%]
半胱硫醚 γ-裂解酶立体化学机制的阐明揭示了底物特异性和催化作用之间的关系
Anna Zmich,Lydia J Perkins,Craig Bingman et al.
Anna Zmich et al.
Pyridoxal phosphate (PLP)-dependent enzymes play essential roles in metabolism and have found applications for organic synthesis and as enzyme therapeutics. The vinylglycine ketimine (VGK) subfamily hosts a growing set of enzymes that play ...
Sulfone Electrophiles in Cross-Electrophile Coupling: Nickel-Catalyzed Difluoromethylation of Aryl Bromides [0.03%]
硫代硫酸酯偶极子在交叉偶联反应中的应用：镍催化芳基溴的二氟甲基化反应
Benjamin K Chi,Samantha J Gavin,Benjamin N Ahern et al.
Benjamin K Chi et al.
Fluoroalkyl fragments have played a critical role in the design of pharmaceutical and agrochemical molecules in recent years due to the enhanced biological properties of fluorinated molecules compared to their non-fluorinated analogues. Des...
Bifunctional Imine Reductase Cascades for the Synthesis of Saturated N-Heterocycles [0.03%]
用于合成饱和氮杂环的双功能亚胺还原酶级联反应
Jeremy I Ramsden,Bruna Zucoloto da Costa,Rachel S Heath et al.
Jeremy I Ramsden et al.
Saturated N-heterocycles constitute a vital scaffold for pharmaceutical chemistry but are challenging to access synthetically, particularly asymmetrically. Here, we demonstrate how imine reductases can achieve annulation through tandem inte...
Covalently Anchored Molecular Catalyst onto a Graphitic Carbon Nitride Surface for Photocatalytic Epoxidation of Olefins [0.03%]
共价锚固分子催化剂到石墨氮化碳表面用于烯烃光氧化合反应
Sebastiano Gadolini,Rachel N Kerber,Riho T Seljamäe-Green et al.
Sebastiano Gadolini et al.
This study explores an innovative photocatalytic approach using pristine graphitic carbon nitride (C3N4) to anchor iron salen-type complexes (FeSalenCl2) without the need for additional linkers or heterojunctions. The resulting hybrid catal...
A High-Throughput Screening Platform for Engineering Poly(ethylene Terephthalate) Hydrolases [0.03%]
一种工程化聚对苯二甲酸乙二醇酯水解酶的高通量筛选平台
Thomas M Groseclose,Erin A Kober,Matilda Clark et al.
Thomas M Groseclose et al.
The ability of enzymes to hydrolyze the ubiquitous polyester, poly(ethylene terephthalate) (PET), has enabled the potential for bioindustrial recycling of this waste plastic. To date, many of these PET hydrolases have been engineered for im...
Perovskite Oxide Materials for Solar Thermochemical Hydrogen Production from Water Splitting through Chemical Looping [0.03%]
用于水解制氢的太阳热化学 looping 反应的钙钛矿氧化物材料
Cijie Liu,Jiyun Park,Héctor A De Santiago et al.
Cijie Liu et al.
Solar-driven thermochemical hydrogen (STCH) production represents a sustainable approach for converting solar energy into hydrogen (H2) as a clean fuel. This technology serves as a crucial feedstock for synthetic fuel production, aligning w...
Simultaneous Photocatalytic Production of H2 and Acetal from Ethanol with Quantum Efficiency over 73% by Protonated Poly(heptazine imide) under Visible Light [0.03%]
可见光照射下质子化聚他pta底亚胺催化剂上乙醇的高效光电催化转化为氢气和醋酸dehyde量子效率超过73%
Vitaliy Shvalagin,Nadezda Tarakina,Bolortuya Badamdorj et al.
Vitaliy Shvalagin et al.
In this work, protonated poly(heptazine imide) (H-PHI) was obtained by adding acid to the suspension of potassium PHI (K-PHI) in ethanol. It was established that the obtained H-PHI demonstrates very high photocatalytic activity in the react...
Development of Tunable Mechanism-Based Carbasugar Ligands that Stabilize Glycoside Hydrolases through the Formation of Transient Covalent Intermediates [0.03%]
通过形成瞬时共价中间体稳定糖苷水解酶的可调机制碳糖配体的发展
Sandeep Bhosale,Sachin Kandalkar,Pierre-André Gilormini et al.
Sandeep Bhosale et al.
Mutations in many members of the set of human lysosomal glycoside hydrolases cause a wide range of lysosomal storage diseases. As a result, much effort has been directed toward identifying pharmacological chaperones of these lysosomal enzym...
Ligand-Metal Cooperation Enables Net Ring-Opening C-C Activation / Difunctionalization of Cyclopropyl Ketones [0.03%]
配体-金属合作催化环丙酮的C-C活化/双官能团化反应
Michael M Gilbert,Michael J Trenerry,Victoria R Longley et al.
Michael M Gilbert et al.
Reactions that cleave C-C bonds and enable functionalization at both carbon sites are powerful strategic tools in synthetic chemistry. Stereodefined cyclopropyl ketones have become readily available and would be an ideal source of 3-carbon ...
Time-Resolved Infrared Spectroscopic Evidence for Interfacial pH-Dependent Kinetics of Formate Evolution on Cu Electrodes [0.03%]
基于铜电极上甲酸演化的时间分辨红外光谱的界面pH依赖动力学证据
Georgios Katsoukis,Hilbert Heida,Merlin Gutgesell et al.
Georgios Katsoukis et al.
By deployment of rapid-scan (second time scale) electrochemical FT-IR reflection-absorption spectroscopy, we studied the reduction of CO2 in 0.1 M Na2SO4 in deuterated water at a pD of 3.7. We report on the impact of dynamic changes in the ...