Recent Developments and Challenges in the Enzymatic Formation of Nitrogen-Nitrogen Bonds [0.03%]
氮氮键酶促合成的最新进展和挑战
Charitomeni Angeli,Sara Atienza-Sanz,Simon Schröder et al.
Charitomeni Angeli et al.
The biological formation of nitrogen-nitrogen (N-N) bonds represents intriguing reactions that have attracted much attention in the past decade. This interest has led to an increasing number of N-N bond-containing natural products (NPs) and...
Combined Kinetic and Computational Analysis of the Palladium-Catalyzed Formylation of Aryl Bromides [0.03%]
结合动力学和计算分析的钯催化芳基溴的Formylation反应
Georgina Rai,Lee J Edwards,Rebecca L Greenaway et al.
Georgina Rai et al.
Aryl aldehydes are key synthetic intermediates in the manufacturing of active pharmaceutical ingredients. They are generated on scale (>1000 kg) through the palladium-catalyzed formylation of aryl bromides using syngas (CO/H2). The best-in-...
Discovery and Synthetic Applications of a NAD(P)H-Dependent Reductive Aminase from Rhodococcus erythropolis [0.03%]
来源于红球菌的NAD(P)H依赖性的胺化酶的发掘及合成应用
Ewald P J Jongkind,Jack Domenech,Arthur Govers et al.
Ewald P J Jongkind et al.
Reductive amination is one of the most synthetically direct routes to access chiral amines. Several Imine Reductases (IREDs) have been discovered to catalyze reductive amination (Reductive Aminases or RedAms), yet they are dependent on the ...
Balancing Activity and Stability through Compositional Engineering of Ternary PtNi-Au Alloy ORR Catalysts [0.03%]
通过三元PtNi-Au合金组成工程在氧还原反应催化剂中调节活性与稳定性关系
Xianxian Xie,Valentín Briega-Martos,Pere Alemany et al.
Xianxian Xie et al.
Achieving the optimal balance between cost-efficiency and stability of oxygen reduction reaction (ORR) catalysts is currently among the key research focuses aiming at reaching a broader implementation of proton-exchange membrane fuel cells ...
Dehydrogenase versus oxidase function: the interplay between substrate binding and flavin microenvironment [0.03%]
脱氢酶与氧化酶功能：底物结合与黄素微环境之间的相互作用
Teresa Benedetta Guerriere,Alessandro Vancheri,Ilaria Ricotti et al.
Teresa Benedetta Guerriere et al.
Redox enzymes, mostly equipped with metal or organic cofactors, can vary their reactivity with oxygen by orders of magnitudes. Understanding how oxygen reactivity is controlled by the protein milieu remains an open issue with broad implicat...
Catalytic Photoredox Carbobromination of Unactivated Alkenes with α-Bromocarbonyls via the Mechanistically Distinct Radical-Addition Radical-Pairing Pathway [0.03%]
通过自由基加成/自由基配对途径实现未活化烯烃与α-溴代羰基化合物的光氧化还原催化的卡宾溴代反应
Harshvardhan Singh,Raj K Tak,Dhruba P Poudel et al.
Harshvardhan Singh et al.
We disclose a catalytic photoredox carbobromination of unactivated alkenes with α-bromocarbonyl compounds under a blue LED light. The reaction proceeds with α-bromoesters, α-bromonitriles and α-bromo-γ-lactones along with terminal and ...
C-H Activation and Sequential Addition to Dienes and Imines: Synthesis of Amines with β-Quaternary Centers and Mechanistic Studies on the Complex Interplay Between the Catalyst and Three Reactants [0.03%]
碳氢键活化及与双烯和亚胺的顺序加成反应：含β-季碳中心胺类化合物的合成及其催化三组分复杂相互作用的机理研究
Ramsey M Goodner,Daniel S Brandes,Gabriel N Morais et al.
Ramsey M Goodner et al.
A Rh(III)-catalyzed sequential C-H bond addition to dienes and in situ formed aldimines was developed, allowing for the preparation of otherwise challenging to access amines with quaternary centers at the β-position. A broad range of diene...
Improving Molecular Iron Ammonia Oxidation Electrocatalysts via Substituent Effects That Modulate Standard Potential and Stability [0.03%]
通过调节标准电位和稳定性的取代效应改进分子铁氨氧化电催化剂
Michael D Zott,Jonas C Peters
Michael D Zott
Molecular ammonia oxidation (AO) catalysis is a rapidly evolving research area. Among the catalysts studied, featuring metals including ruthenium, iron, manganese, nickel, and copper, polypyridyl iron complexes are attractive owing to fast ...
Characterization of VldE (Spr1875), a Pneumococcal Two-State l,d-Endopeptidase with a Four-Zinc Cluster in the Active Site [0.03%]
表征VldE（Spr1875），一种肺炎链球菌的两态l，d-内肽酶，具有四锌簇活性位点
Vega Miguel-Ruano,Iván Acebrón,Mijoon Lee et al.
Vega Miguel-Ruano et al.
Remodeling of the pneumococcal cell wall, carried out by peptidoglycan (PG) hydrolases, is imperative for maintaining bacterial cell shape and ensuring survival, particularly during cell division or stress response. The Streptococcus pneumo...
Light-Driven Hybrid Nanoreactor Harnessing the Synergy of Carboxysomes and Organic Frameworks for Efficient Hydrogen Production [0.03%]
一种光驱动的结合羧酶体和有机框架的纳米反应器用于高效制氢
Jing Yang,Qiuyao Jiang,Yu Chen et al.
Jing Yang et al.
Synthetic photobiocatalysts are promising catalysts for valuable chemical transformations by harnessing solar energy inspired by natural photosynthesis. However, the synergistic integration of all of the components for efficient light harve...