Substrate Trapping in Polyketide Synthase Thioesterase Domains: Structural Basis for Macrolactone Formation [0.03%]
泛酮合成酶酰基载体蛋白-硫酯酶结构域的底物捕获及大环内酯形成机理
Tyler M McCullough,Vishakha Choudhary,David L Akey et al.
Tyler M McCullough et al.
Emerging antibiotic resistance requires continual improvement in the arsenal of antimicrobial drugs, especially the critical macrolide antibiotics. Formation of the macrolactone scaffold of these polyketide natural products is catalyzed by ...
Intermolecular Anti-Markovnikov Hydroamination of Alkenes with Sulfonamides, Sulfamides, and Sulfamates [0.03%]
通过磺酰胺、亚磺酰胺和磺亚胺酯与烯烃的分子间反马氏氢氨化反应
Angela Lin,Mathis J Karrasch,Qiaolin Yan et al.
Angela Lin et al.
A general method for the light-driven intermolecular anti-Markovnikov hydroamination of alkenes with primary sulfonamides, sulfamides, and sulfamates is presented. The reaction is mediated by a ternary catalyst system composed of an iridium...
Catalyst-Substrate Pairings for Carbocyclic and Heterocyclic Systems in Atroposelective Quinazolinone Synthesis [0.03%]
用于光学活性喹唑啉酮合成中碳环和杂环体系的催化剂-底物组合研究
Melody C Guo,Scott J Miller
Melody C Guo
Asymmetric catalytic reaction development depends critically on the matching of an appropriate catalytic scaffold with a substrate of interest. In many cases, a catalyst will be discovered to be quite selective for a given substrate, and th...
Selective α-Hydroxyketone Formation and Subsequent C-C Bond Cleavage by Cytochrome P450 Monooxygenase Enzymes [0.03%]
Cytochrome P450单加氧酶的选择性α-羟基酮形成及后续C-C键断裂反应
Joel H Z Lee,Tom Coleman,Mark A Mclean et al.
Joel H Z Lee et al.
The heme enzymes of the cytochrome P450 superfamily (CYPs) catalyze oxidation reactions with a high level of selectivity. Here, the CYP199A4 enzyme from the bacterium Rhodopseudomonas palustris HaA2 is used to catalyze the hydroxylation of ...
Cross-Coupling Reactions with Nickel, Visible Light, and tert-Butylamine as a Bifunctional Additive [0.03%]
镍催化下叔丁胺作为双功能添加剂的光促交叉偶联反应研究
Jonas Düker,Maximilian Philipp,Thomas Lentner et al.
Jonas Düker et al.
Transition metal catalysis is crucial for the synthesis of complex molecules, with ligands and bases playing a pivotal role in optimizing cross-coupling reactions. Despite advancements in ligand design and base selection, achieving effectiv...
Reactions of Surface Peroxides Contribute to Rates and Selectivities for C2H4 Epoxidation on Silver [0.03%]
表面过氧化物反应促进银催化剂上环氧丙烷选择性合成反应速率及选择性
Ching-Tien Chen,Anna Sviripa,Sugandha Verma et al.
Ching-Tien Chen et al.
Partial oxidation of ethylene over silver catalysts produces more than 30 million metric tons of ethylene oxide (EO) annually. However, the form of active silver surfaces, reactive oxygen species, and dominant pathways of this chemical reac...
Monitoring Radical Intermediates in Photoactivated Palladium-Catalyzed Coupling of Aryl Halides to Arenes by an Aryl Radical Assay [0.03%]
通过芳基自由基测定法监测光活化钯催化芳基卤与芳烃偶联反应中的自由基中间体
Seb Tyerman,Donald G MacKay,Kenneth F Clark et al.
Seb Tyerman et al.
An aryl radical assay is used to provide information about the formation of aryl radicals from aryl halides in coupling reactions to arenes in the presence of palladium sources and under LED irradiation (λ = 456 nm). The assay uses 2-halo-...
Bioinformatics and Computationally Supported Redesign of Aspartase for β-Alanine Synthesis by Acrylic Acid Hydroamination [0.03%]
计算支持的天冬氨酸酶生物信息学重新设计以通过丙烯酸氨化合成β-丙氨酸
Alejandro Gran-Scheuch,Hein J Wijma,Nikolas Capra et al.
Alejandro Gran-Scheuch et al.
Aspartate ammonia lyases catalyze the reversible amination of fumarate to l-aspartate. Recent studies demonstrate that the thermostable enzyme from Bacillus sp. YM55-1 (AspB) can be engineered for the enantioselective production of substitu...
Acridine/Lewis Acid Complexes as Powerful Photocatalysts: A Combined Experimental and Mechanistic Study [0.03%]
吖啶/路易斯酸复合物强大的光催化剂：实验与机理研究相结合的方法
Dillon R L Rickertsen,Joshua L Crow,Tamal Das et al.
Dillon R L Rickertsen et al.
A class of in-situ generated Lewis acid (LA) activated acridine complexes is reported, which act as potent photochemical catalysts for the oxidation of a variety of protected secondary amines. Acridine/LA complexes exhibit tunable excited s...
Reactivity and Mechanism of Recoverable Pd1@C3N4 Single-Atom Catalyst in Buchwald-Hartwig Aminations [0.03%]
布氏-哈特维克氨基化反应中可回收的Pd₁@C₃N₄单原子催化剂的活性及作用机制研究
Georgios Giannakakis,Marc Eduard Usteri,Aram Bugaev et al.
Georgios Giannakakis et al.
Buchwald-Hartwig (BH) aminations are crucial for synthesizing arylamine motifs in numerous bioactive molecules and fine chemicals. While homogeneous palladium complexes can be effective catalysts, their high costs and environmental impact m...