A Bacterial β1-3-Galactosyltransferase Enables Multigram-Scale Synthesis of Human Milk Lacto- N-tetraose (LNT) and Its Fucosides [0.03%]
一种细菌β1-3-半乳糖基转移酶能够实现人乳低聚糖岩藻四糖(LNT)及其岩藻基的克级合成
John B McArthur,Hai Yu,Xi Chen
John B McArthur
β1-3-Linked galactosides such as Galβ1‒3GlcNAcβOR are common carbohydrate motifs found in human milk oligosaccharides (HMOSs), glycolipids, and glycoproteins. Efficient and scalable enzymatic syntheses of these structures have proven ch...
Dissecting the Mechanism of (R)-3-Hydroxybutyrate Dehydrogenase by Kinetic Isotope Effects, Protein Crystallography, and Computational Chemistry [0.03%]
利用动力学同位素效应、蛋白质晶体学和计算化学剖析（R）-3-羟基丁酸脱氢酶的机制
Teresa F G Machado,Miha Purg,Stephen A McMahon et al.
Teresa F G Machado et al.
The enzyme (R)-3-hydroxybutyrate dehydrogenase (HBDH) catalyzes the enantioselective reduction of 3-oxocarboxylates to (R)-3-hydroxycarboxylates, the monomeric precursors of biodegradable polyesters. Despite its application in asymmetric re...
First-Principles-Based Multiscale Modelling of Nonoxidative Butane Dehydrogenation on Cr2O3(0001) [0.03%]
基于第一性原理的丁烷非氧化脱氢Cr2O3(0001)多尺度模拟模型
Drejc Kopač,Damjan Lašič Jurković,Blaž Likozar et al.
Drejc Kopač et al.
Propane (C3H8) and butane (C4H10) are short straight-chain alkane molecules that are difficult to convert catalytically. Analogous to propane, butane can be dehydrogenated to butenes (also known as butylenes) or butadiene, which are used in...
Clara Rettenmaier,Rosa M Arán-Ais,Janis Timoshenko et al.
Clara Rettenmaier et al.
The formic acid oxidation reaction (FAOR) is one of the key reactions that can be used at the anode of low-temperature liquid fuel cells. To allow the knowledge-driven development of improved catalysts, it is necessary to deeply understand ...
Catalytic Roles of Coenzyme Pyridoxal-5'-phosphate (PLP) in PLP-dependent Enzymes: Reaction Pathway for Methionine-γ-lyase-catalyzed L-methionine Depletion [0.03%]
吡哆醛-5'-磷酸(PKP)在PKP依赖型酶中的催化作用：甲硫氨酰-γ-裂解酶催化的L-蛋氨酸分解反应路径研究
Zhe Li,Yunsong Zhao,Huifang Zhou et al.
Zhe Li et al.
Pyridoxal-5'-phosphate (PLP), the active form of vitamin B6, is an important and versatile coenzyme involved in a variety of enzymatic reactions, accounting for about 4% of all classified activities. However, the detailed catalytic reaction...
Dmitriy Borodin,Kai Golibrzuch,Michael Schwarzer et al.
Dmitriy Borodin et al.
Up to now, methods for measuring rates of reactions on catalysts required long measurement times involving signal averaging over many experiments. This imposed a requirement that the catalyst return to its original state at the end of each ...
Molecular Control of the Catalytic Properties of Rhodium Nanoparticles in Supported Ionic Liquid Phase (SILP) Systems [0.03%]
固液杂化体系中Rh纳米粒子的催化性能及其分子调控机制研究
Alexis Bordet,Gilles Moos,Calum Welsh et al.
Alexis Bordet et al.
Rhodium nanoparticles (NPs) immobilized on imidazolium-based supported ionic liquid phases (Rh@SILP) act as effective catalysts for the hydrogenation of biomass-derived furfuralacetone. The structure of ionic liquid-type (IL) molecular modi...
Influence of Nanoscale Intimacy and Zeolite Micropore Size on the Performance of Bifunctional Catalysts for n-Heptane Hydroisomerization [0.03%]
纳米亲密度和分子筛微孔尺寸对正庚烷氢异构化双功能催化剂性能的影响
Jogchum Oenema,Justine Harmel,Roxana Pérez Vélez et al.
Jogchum Oenema et al.
In this study, Pt nanoparticles on zeolite/γ-Al2O3 composites (50/50 wt) were located either in the zeolite or on the γ-Al2O3 binder, hereby varying the average distance (intimacy) between zeolite acid sites and metal sites from "closest"...
Wuyuan Zhang,Huanhuan Liu,Morten M C H van Schie et al.
Wuyuan Zhang et al.
It is well-known that energy-rich radiation induces water splitting, eventually yielding hydrogen peroxide. Synthetic applications, however, are scarce and to the best of our knowledge, the combination of radioactivity with enzyme-catalysis...
Nature's Machinery, Repurposed: Expanding the Repertoire of Iron-Dependent Oxygenases [0.03%]
铁依赖型氧合酶的再利用：扩大铁依赖型氧合酶的谱系
Noah P Dunham,Frances H Arnold
Noah P Dunham
Iron is an especially important redox-active cofactor in biology because of its ability to mediate reactions with atmospheric O2. Iron-dependent oxygenases exploit this earth-abundant transition metal for the insertion of oxygen atoms into ...