Impact of Chronic Constipation and Subtypes on Serum Trimethylamine-N-oxide Levels and Their Reduction with Treatment: Multicenter Observational Study [0.03%]
Yo Ishihara,Eikichi Ihara,Hidenori Ohkubo et al.
Yo Ishihara et al.
Background: Chronic constipation (CC) is associated with increased cardiovascular events, and trimethylamine N-oxide (TMAO), a gut microbiota-derived metabolite, has been recently shown to correlate with this risk. We exa...
Replication of endotypes in eosinophilic esophagitis using a curated gene panel compared to bulk sequencing and assessing stability over time [0.03%]
Evan S Dellon,Yihsuan S Tsai,Joel S Parker et al.
Evan S Dellon et al.
Background: It is unknown whether eosinophilic esophagitis (EoE) endotypes can be replicated using whole transcriptome data or if endotypes persist after treatment. We investigated endotypes with a curated gene panel and ...
Prophylactic Clip Closure to Prevent Bleeding After Colorectal Endoscopic Submucosal Dissection: A Cost-Effectiveness Study [0.03%]
Daryl Ramai,Abdulrahman Qatomah,Patrick Magahis et al.
Daryl Ramai et al.
Background and aims: Endoscopic submucosal dissection (ESD) enables en-bloc resection of large and complex colorectal neoplasms but is associated with a clinically significant risk of delayed bleeding. Prophylactic clip c...
Oxyntic gland intraepithelial T lymphocytes as progression marker of potential autoimmune gastritis [0.03%]
Marco Vincenzo Lenti,Giovanni Santacroce,Emanuela Miceli et al.
Marco Vincenzo Lenti et al.
Background: Autoimmune gastritis (AIG) is a chronic immune-mediated disease with potential for serious clinical consequences, yet early identification remains challenging. We aimed to assess whether deep oxyntic gland int...
Automated Eosinophil Quantification Using Deep Learning to Predict Therapy Escalation in Pediatric Ulcerative Colitis [0.03%]
James Reigle,Xiaoxuan Liu,Oscar Lopez-Nunez et al.
James Reigle et al.
Background: Emerging evidence implicates eosinophils as important modulators of disease activity and therapeutic response in ulcerative colitis. Automated image analysis provides a scalable and reproducible approach to th...
PFKP Drives Immune Checkpoint Co-Expression and Metabolic Pathway Activation in Liver Cancer: TCGA-Based and Experimental Validation [0.03%]
Lilan Cen,Zhe Tian,Haoming Hua et al.
Lilan Cen et al.
Introduction: Hepatocellular carcinoma (HCC) is associated with poor clinical outcomes, underscoring the need to identify novel biomarkers and therapeutic targets. PFKP, a key rate-limiting enzyme in glycolysis, is involv...
A Transformer-ResNet-Integrated Deep Learning Model for Digital Pathology-Based Grading and Risk Stratification of MASLD-Related Liver Fibrosis [0.03%]
一种Transformer-ResNet集成的深度学习模型用于MASLD相关肝纤维化分级和风险分层数字病理学研究
Hongtao Pan,Rongrong Zhang,Shuai Zhou et al.
Hongtao Pan et al.
Introduction: Metabolic dysfunction-associated steatotic liver disease (MASLD) affects up to 30% of the global population and drives progression to fibrosis, cirrhosis, and liver cancer, yet early-stage identification rem...
Sheel Patel,Nimish Thakra,Akash Shukla et al.
Sheel Patel et al.
Alcohol use disorder (AUD) is a prevalent public health challenge currently. Alcohol-associated liver disease (ALD), the commonest end-organ damage, is increasing at an alarming rate. It is currently the leading cause worldwide of hospitali...
"Predictors of Missed Appointments in Digestive Health: A Comparative Analysis of Telehealth and In-Person Visits" [0.03%]
消化系统疾病患者失约预测因素：远程医疗和面对面就诊的比较分析
Himesh B Zaver,Olivia Reszczynski,Aditya Singh et al.
Himesh B Zaver et al.
Background: Telehealth access is integral to digestive healthcare. This study examined demographic, insurance, and social determinants of health associated with missed telehealth appointments, with secondary comparisons t...
Fourteen-day vonoprazan-minocycline versus vonoprazan-amoxicillin dual therapy for primary Helicobacter pylori infection: A propensity score matching analysis [0.03%]
14天沃诺拉赞-米诺环素与沃诺拉赞-阿莫西林二联疗法治疗幽门螺杆菌初次感染的一项倾向性匹配分析
Meng Li,Xiaolei Wang,Xinhong Dong et al.
Meng Li et al.
Background: The therapeutic strategies available to eradicate Helicobacter pylori infection in individuals allergic to penicillin remain constrained, and regimens containing minocycline are considered potential alternativ...