The role of the oncogenic Rab35 in cancer invasion, metastasis, and immune evasion, especially in leukemia [0.03%]
致癌性Rab35在癌症侵袭、转移和免疫逃逸中的作用，特别是在白血病中
Fabian R Villagomez,Oscar Medina-Contreras,Jorge Francisco Cerna-Cortes et al.
Fabian R Villagomez et al.
The study of cancer has allowed researchers to describe some biological characteristics that tumor cells acquire during their development, known as the "hallmarks of cancer" but more research is needed to expand our knowledge about cancer b...
Bart Nieuwenhuis,Richard Eva
Bart Nieuwenhuis
Adult central nervous system (CNS) axons do not regenerate after injury because of extrinsic inhibitory factors, and a low intrinsic capacity for axon growth. Developing CNS neurons have a better regenerative ability, but lose this with mat...
Filling GAPs in G protein- coupled receptor (GPCR)-mediated Ras adaptation and chemotaxis [0.03%]
填补G蛋白偶联受体介导的Ras适应和化学趋向性机制中的空白(GAPs)
Xuehua Xu
Xuehua Xu
Eukaryotic cells sense and migrate toward chemoattractant gradients using G protein-coupled receptor (GPCR) signaling pathways. The fascinating feature of chemotaxis is that cells migrate through chemoattractant gradients with huge concentr...
"Examining RAS pathway rewiring with a chemically inducible activator of RAS" [0.03%]
“用化学诱导的RAS激活剂研究RAS通路的重新连接”
John C Rose,Emily M Dieter,Daniel Cunningham-Bryant et al.
John C Rose et al.
RAS signaling pathways govern diverse cellular processes, are dynamic, and exhibit marked plasticity. Yet, these features also present a considerable obstacle to their study. Here, we report the use of a recently described RAS rheostat, Che...
The Rap2c GTPase facilitates B cell receptor-induced reorientation of the microtubule-organizing center [0.03%]
Rap2c GTP酶通过促进B细胞受体诱导的微管组织中心重新定向来发挥作用
Jia C Wang,Jeff Y-J Lee,May Dang-Lawson et al.
Jia C Wang et al.
When B lymphocytes encounter antigen-bearing surfaces, B-cell receptor (BCR) signaling initiates remodeling of the F-actin network and reorientation of the microtubule-organizing center (MTOC) towards the antigen contact site. We have previ...
Reciprocal regulation of YAP/TAZ by the Hippo pathway and the Small GTPase pathway [0.03%]
Hippo通路和小G蛋白通路的相互调节关系
Ju-Won Jang,Min-Kyu Kim,Suk-Chul Bae
Ju-Won Jang
Yes-associated protein 1 (YAP) and transcriptional co-activator with PDZ-binding motif (TAZ) (YAP/TAZ) are transcriptional coactivators that regulate genes involved in proliferation and transformation by interacting with DNA-binding transcr...
Shedding new light on RhoA signalling as a drug target in vivo using a novel RhoA-FRET biosensor mouse [0.03%]
利用新型RhoA-FRET生物传感器小鼠在活体内重新评估RhoA信号转导作为药物靶点的作用
Max Nobis,David Herrmann,Sean C Warren et al.
Max Nobis et al.
The small GTPase RhoA is a master regulator of signalling in cell-extracellular matrix interactions. RhoA signalling is critical to many cellular processes including migration, mechanotransduction, and is often disrupted in carcinogenesis. ...
Acute compressive stress activates RHO/ROCK-mediated cellular processes [0.03%]
急性压缩应力激活RHO/ROCK介导的细胞过程
Sarah T Boyle,Jasreen Kular,Max Nobis et al.
Sarah T Boyle et al.
The ability to rapidly respond to applied force underpins cell/tissue homeostasis. This response is mediated by mechanotransduction pathways that regulate remodeling and tension of the actomyosin cytoskeleton to counterbalance external forc...
Multiple Rap1 effectors control Epac1-mediated tightening of endothelial junctions [0.03%]
多个Rap1效应因子控制Epac1介导的内皮细胞连接紧密化作用
Willem-Jan Pannekoek,Marjolein J Vliem,Johannes L Bos
Willem-Jan Pannekoek
Epac1 and Rap1 mediate cAMP-induced tightening of endothelial junctions. We have previously found that one of the mechanisms is the inhibition of Rho-mediated tension in radial stress fibers by recruiting the RhoGAP ArhGAP29 in a complex co...
Jean Claude Hervé,Nicolas Bourmeyster
Jean Claude Hervé