Analysis of Ras-effector interaction competition in large intestine and colorectal cancer context [0.03%]
基于大肠和结直肠癌的Ras-效应因子相互作用竞争分析
Verónica Ibáňez Gaspar,Simona Catozzi,Camille Ternet et al.
Verónica Ibáňez Gaspar et al.
Cancer is the second leading cause of death globally, and colorectal cancer (CRC) is among the five most common cancers. The small GTPase KRAS is an oncogene that is mutated in ~30% of all CRCs. Pharmacological treatments of CRC are current...
Cristina Uribe-Alvarez,Sandra Lucía Guerrero-Rodríguez,Jennifer Rhodes et al.
Cristina Uribe-Alvarez et al.
Malignant melanoma is characterized by mutations in a number of driver genes, most notably BRAF and NRAS. Recent genomic analyses revealed that 4-9% of sun-exposed melanomas bear activating mutations in RAC1, which encodes a small GTPase th...
Imge Ozugergin,Alisa Piekny
Imge Ozugergin
The Ran pathway has a well-described function in nucleocytoplasmic transport, where active Ran dissociates importin/karyopherin-bound cargo containing a nuclear localization signal (NLS) in the nucleus. As cells enter mitosis, the nuclear e...
Correction [0.03%]
改正措施
Published Erratum
Small GTPases. 2021 Jan;12(1):79. DOI:10.1080/21541248.2020.1713572 2021
ARL3, a small GTPase with a functionally conserved role in primary cilia and immune synapses [0.03%]
具有功能保守作用的小GTP酶ARD3在原纤毛和免疫突触中的作用
Laura Powell,Youhani H Samarakoon,Shehab Ismail et al.
Laura Powell et al.
The primary cilium and the immunological synapse are both specialized functional plasma membrane domains that share several similarities. Signalling output of membrane domains is regulated, spatially and temporally, by segregating and focus...
PKCε regulates Rho GTPases and actin cytoskeleton reorganization in non-small cell lung cancer cells [0.03%]
蛋白激酶调节非小细胞肺癌细胞中的Rho GTP酶和肌动蛋白细胞重组
Mariana Cooke,Martin J Baker,Marcelo G Kazanietz et al.
Mariana Cooke et al.
Oncogenic protein kinase C epsilon (PKCε) promotes the formation of membrane ruffles and motility in non-small cell lung cancer (NSCLC) cells. We found that PKCε is down-regulated when NSCLC cells undergo epithelial-to-mesenchymal transit...
The small GTPase RAB-35 facilitates the initiation of phagosome maturation and acts as a robustness factor for apoptotic cell clearance [0.03%]
RAB-35小GTP酶促进吞噬体成熟的启动并作为凋亡细胞清除的稳健性因子
Ryan Haley,Zheng Zhou
Ryan Haley
We recently identified the novel function of the small GTPase RAB-35 in apoptotic cell clearance in Caenorhabditis elegans, a process in which dying cells are engulfed and degraded inside phagosomes. We have found that RAB-35 functions in t...
Fgd5 is a Rac1-specific Rho GEF that is selectively inhibited by aurintricarboxylic acid [0.03%]
Fgd5是Rac1特异性的Rho交换因子，并且可被吐根三羧酸选择性抑制
Sally Park,Yitian Guo,Judeah Negre et al.
Sally Park et al.
Rho proteins are signalling molecules that control cellular dynamics, movement and morphological changes. They are activated by Rho guanine-nucleotide exchange factors (Rho GEFs) that transduce upstream signals into Rho-mediated activation ...
LRRK2 binds to the Rab32 subfamily in a GTP-dependent manner via its armadillo domain [0.03%]
LRRK2通过其犰狳结构域以GTP依赖性的方式与Rab32亚家族结合
Emma McGrath,Dieter Waschbüsch,Brian M Baker et al.
Emma McGrath et al.
LRRK2 is a multi-domain Ser/Thr kinase that is associated with inherited and sporadic cases of Parkinson's disease. Many mutations linked to disease are associated within a central ROC-COR regulatory region and the subsequent kinase domain,...
Ana Carmena
Ana Carmena
Non-muscle myosin II molecules are actin-binding proteins with ATPase activity, this latter capacity providing the energy required for actin filament cross-linking and contraction. The activation of these molecular motors relies on direct p...