Phylogenetic reconstruction and evolution of the Rab GTPase gene family in Amoebozoa [0.03%]
全纤毛amoebozoa类群中Rab GTP酶基因家族的系统发育与进化分析
Alfredo L Porfírio-Sousa,Alexander K Tice,Matthew W Brown et al.
Alfredo L Porfírio-Sousa et al.
Rab GTPase is a paralog-rich gene family that controls the maintenance of the eukaryotic cell compartmentalization system. Diverse eukaryotes have varying numbers of Rab paralogs. Currently, little is known about the evolutionary pattern of...
The progress in C9orf72 research: ALS/FTD pathogenesis, functions and structure [0.03%]
C9orf72研究的进展：ALS/FTD发病机制、功能和结构
Lan Jiang,Tizhong Zhang,Kefeng Lu et al.
Lan Jiang et al.
The hexanucleotide repeat (GGGGCC) expansion in C9orf72 is accounted for a large proportion of the genetic amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). The hypotheses of how the massive G4C2 repeats in C9orf72 dest...
Biallelic ELMO3 mutations and loss of function for DOCK-mediated RAC1 activation result in intellectual disability [0.03%]
ELMO3双等位基因突变和DOCK介导的RAC1激活失活导致智力残疾
Viviane Tran,Marie-Anne Goyette,Mónica Martínez-García et al.
Viviane Tran et al.
The engulfment and cell motility 3 (ELMO3) protein belongs to the ELMO-family of proteins. ELMO proteins form a tight complex with the DOCK1-5 guanine nucleotide exchange factors that regulate RAC1 spatiotemporal activation and signalling. ...
Case Reports
Small GTPases. 2022 Jan;13(1):48-55. DOI:10.1080/21541248.2021.1888557 2022
William Vainchenker,Brahim Arkoun,Francesca Basso-Valentina et al.
William Vainchenker et al.
Megakaryocytes (MKs) are the bone marrow (BM) cells that generate blood platelets by a process that requires: i) polyploidization responsible for the increased MK size and ii) cytoplasmic organization leading to extension of long pseudopods...
Investigating increased hematopoietic stem cell fitness in a novel mouse model [0.03%]
利用新型小鼠模型研究造血干细胞功能增强现象
Laila Karra,Jeroen P Roose
Laila Karra
T-cell acute lymphoblastic leukaemia (T-ALL) is a bone marrow (BM) malignancy affecting children and adults. Typically treated with chemotherapy, leukaemia remains a major death cause in people under 20 years old. Understanding molecularly ...
Paul Rivier,Michel Mubalama,Olivier Destaing
Paul Rivier
Cell invasion is associated with numerous patho-physiologic states including cell development and metastatic dissemination. This process couples the activation of cell motility with the capacity to degrade the extracellular matrix, thereby ...
Rho GTPase regulation of reactive oxygen species generation and signalling in platelet function and disease [0.03%]
Rho GTP酶在血小板功能和疾病中调节活性氧生成及信号转导的作用
Anh T P Ngo,Ivan Parra-Izquierdo,Joseph E Aslan et al.
Anh T P Ngo et al.
Platelets are master regulators and effectors of haemostasis with increasingly recognized functions as mediators of inflammation and immune responses. The Rho family of GTPase members Rac1, Cdc42 and RhoA are known to be major components of...
Down-regulation of miR-140-3p is a cause of the interlukin-13-induced up-regulation of RhoA protein in bronchial smooth muscle cells [0.03%]
miR-140-3p下调是白细胞介素-13诱导的支气管平滑肌细胞RhoA蛋白上调的原因
Yoshihiko Chiba,Yusuke Ando,Yasuna Kato et al.
Yoshihiko Chiba et al.
The current study aimed to determine the role of a microRNA (miRNA), miR-140-3p, in the control of RhoA expression in bronchial smooth muscle cells (BSMCs). In cultured human BSMCs, incubation with interleukin-13 (IL-13) caused an up-regula...
Mitochondrial Miro GTPases coordinate mitochondrial and peroxisomal dynamics [0.03%]
线粒体Miro GTP酶协调线粒体和过氧化物酶体的动态性
Konrad E Zinsmaier
Konrad E Zinsmaier
Mitochondria and peroxisomes are highly dynamic, multifunctional organelles. Both perform key roles for cellular physiology and homoeostasis by mediating bioenergetics, biosynthesis, and/or signalling. To support cellular function, they mus...
Regulation and functions of the RhoA regulatory guanine nucleotide exchange factor GEF-H1 [0.03%]
GEF-H1的结构、调控及其生物学功能研究
Emily Joo,Michael F Olson
Emily Joo
Since the discovery by Madaule and Axel in 1985 of the first Ras homologue (Rho) protein in Aplysia and its human orthologue RhoB, membership in the Rho GTPase family has grown to 20 proteins, with representatives in all eukaryotic species....