Biallelic ELMO3 mutations and loss of function for DOCK-mediated RAC1 activation result in intellectual disability
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The engulfment and cell motility 3 (ELMO3) protein belongs to the ELMO-family of proteins. ELMO proteins form a tight complex with the DOCK1-5 guanine nucleotide exchange factors that regulate RAC1 spatiotemporal activation and signalling. DOCK proteins and RA... ...
