Rab3a, a small GTP-binding protein, is required for the stabilization of the murine leukaemia virus Gag protein [0.03%]
小GTP结合蛋白Rab3a对小鼠 leukemia病毒Gag蛋白稳定所必需
Mai Izumida,Katsura Kakoki,Hideki Hayashi et al.
Mai Izumida et al.
We recently identified a CD63-interacting protein to understand the role of CD63 in virion production of the human immunodeficiency virus type 1, and we have found that Rab3a forms a complex with CD63. In this study, we analysed the effect ...
Clara Steichen,Claude Hervé,Thierry Hauet et al.
Clara Steichen et al.
Rho family GTPases are molecular switches best known for their pivotal role in dynamic regulation of the actin cytoskeleton, but also of cellular morphology, motility, adhesion and proliferation. The prototypic members of this family (RhoA,...
Photodynamic treatment modulates various GTPase and cellular signalling pathways in Tauopathy [0.03%]
光动力治疗可调节Tau病中的各种GTP酶和细胞信号转导途径
Tushar Dubey,Subashchandrabose Chinnathambi
Tushar Dubey
The application of photo-excited dyes for treatment is known as photodynamic therapy (PDT). PDT is known to target GTPase proteins in cells, which are the key proteins of diverse signalling cascades which ultimately modulate cell proliferat...
Small GTPases modulate intrinsic and extrinsic forces that control epithelial folding in Drosophila embryos [0.03%]
小GTP酶调节控制果蝇胚胎上皮折叠的内在和外在力量
Ashley Rich,Michael Glotzer
Ashley Rich
Epithelial folding is a common means to execute morphogenetic movements. The gastrulating Drosophila embryo offers many examples of epithelial folding events, including the ventral, cephalic, and dorsal furrows. Each of these folding events...
You Wu,David J Reiner
You Wu
Ras is the most mutated oncoprotein in cancer. Among the three oncogenic effectors of Ras - Raf, PI3 Kinase and RalGEF>Ral - signalling through RalGEF>Ral (Ras-like) is by far the least well understood. A variety of signals and binding part...
Rac-maninoff and Rho-vel: The symphony of Rho-GTPase signaling at excitatory synapses [0.03%]
Rac-Maninoff和Rho-Vel：兴奋性突触Rho-GTP酶信号的交响曲
Joseph G Duman,Francisco A Blanco,Christopher A Cronkite et al.
Joseph G Duman et al.
Synaptic connections between neurons are essential for every facet of human cognition and are thus regulated with extreme precision. Rho-family GTPases, molecular switches that cycle between an active GTP-bound state and an inactive GDP-bou...
Targeting the KRAS α4-α5 allosteric interface inhibits pancreatic cancer tumorigenesis [0.03%]
靶向KRAS α4-α5变构界面可抑制胰腺癌的致癌作用
Imran Khan,Catherine Marelia-Bennet,Julia Lefler et al.
Imran Khan et al.
RAS is the most frequently mutated oncogene in human cancer with nearly ~20% of cancer patients possessing mutations in one of three RAS genes (K, N or HRAS). However, KRAS is mutated in nearly 90% of pancreatic ductal carcinomas (PDAC). Al...
The anti-Rac1-GTP antibody and the detection of active Rac1: a tool with a fundamental flaw [0.03%]
一种抗Rac1-GTP抗体及其检测活化型Rac1的缺陷性方法
Martin J Baker,Marcelo G Kazanietz
Martin J Baker
Rac1 is a member of the Rho GTPase family and is involved in many cellular processes, particularly the formation of actin-rich membrane protrusions, such as lamellipodia and ruffles. With such a widely studied protein, it is essential that ...
The N-terminal Leu-Pro-Gln sequence of Rab34 is required for ciliogenesis in hTERT-RPE1 cells [0.03%]
N端Leu-Pro-Gln序列对Rab34在hTERT-RPE1细胞中的纤毛发生是必需的
Mai E Oguchi,Yuta Homma,Mitsunori Fukuda
Mai E Oguchi
We have previously shown that Rab34 is an important regulator of ciliogenesis and that its unique long N-terminal region (amino acids 1-49) is essential for ciliogenesis in certain cultured mammalian cells. In the present study, we performe...
Aishwarya Omble,Kiran Kulkarni
Aishwarya Omble
Cell migration, a crucial step in numerous biological processes, is tightly regulated in space and time. Cells employ Rho GTPases, primarily Rho, Rac, and Cdc42, to regulate their motility. Like other small G proteins, Rho GTPases function ...