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The anti-Rac1-GTP antibody and the detection of active Rac1: a tool with a fundamental flaw

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Rac1 is a member of the Rho GTPase family and is involved in many cellular processes, particularly the formation of actin-rich membrane protrusions, such as lamellipodia and ruffles. With such a widely studied protein, it is essential that the research communi... ...