Quantitation of RhoA activation: differential binding to downstream effectors [0.03%]
RhoA激活的定量：与下游作用分子的不同结合
Yu-Wen Zhang,Holly M Torsilieri,James E Casanova
Yu-Wen Zhang
The small GTPase RhoA controls many important cellular processes through its ability to activate multiple downstream effector pathways. Most RhoA effectors contain a Rho-binding domain (RBD), and interaction between active RhoA and the RBD ...
Neda S Kazemein Jasemi,Mohammad R Ahmadian
Neda S Kazemein Jasemi
RAS activation is a multiple-step process in which linkage of the extracellular stimuli to the RAS activator SOS1 is the main step in RAS activation. GRB2 adaptor protein is the main modulator in SOS1 recruitment to the plasma membrane and ...
Siqi Li,Christopher M Counter
Siqi Li
The RAS family of small GTPases is mutated in roughly a fifth of human cancers. Hotspot point mutations at codons G12, G13, and Q61 account for 95% of all these mutations, which are well established to render the encoded proteins oncogenic....
Deletion of murine Rhoh leads to de-repression of Bcl-6 via decreased KAISO levels and accelerates a malignancy phenotype in a murine model of lymphoma [0.03%]
在淋巴瘤小鼠模型中，删除Rhoh通过降低KAISO水平导致Bcl-6去活化并加速恶性表型的发展
Hiroto Horiguchi,Haiming Xu,Beatrice Duvert et al.
Hiroto Horiguchi et al.
RHOH/TFF, a member of the RAS GTPase super family, has important functions in lymphopoiesis and proximal T cell receptor signalling and has been implicated in a variety of leukaemias and lymphomas. RHOH was initially identified as a translo...
Unexplored Cdc42 functions at the budding yeast nucleus suggested by subcellular localization [0.03%]
芽殖酵母核中未被发现的Cdc42功能由亚细胞定位推测得出
Michelle S Lu,David G Drubin
Michelle S Lu
In budding yeast, the Rho-family GTPase Cdc42 has several functions that depend on its subcellular localization and the cell cycle stage. During bud formation, Cdc42 localizes to the plasma membrane at the bud tip and bud neck where it carr...
Interactome and evolutionary conservation of Dictyostelid small GTPases and their direct regulators [0.03%]
柄虫菌小型GTP酶及其直接调节因子的相互作用和进化保守性
Gillian Forbes,Christina Schilde,Hajara Lawal et al.
Gillian Forbes et al.
GTP binding proteins known as small GTPases make up one of the largest groups of regulatory proteins and control almost all functions of living cells. Their activity is under, respectively, positive and negative regulation by guanine nucleo...
Magali Mathieu,Valérie Steier,Florence Fassy et al.
Magali Mathieu et al.
KRAS genes belong to the most frequently mutated family of oncogenes in cancer. The G12C mutation, found in a third of lung, half of colorectal and pancreatic cancer cases, is believed to be responsible for a substantial number of cancer de...
Seeing is believing: tools to study the role of Rho GTPases during cytokinesis [0.03%]
眼见为实：研究胞质分裂过程中Rho GTP酶作用的工具
Su Pin Koh,Nhat Phi Pham,Alisa Piekny
Su Pin Koh
Cytokinesis is required to cleave the daughter cells at the end of mitosis and relies on the spatiotemporal control of RhoA GTPase. Cytokinesis failure can lead to changes in cell fate or aneuploidy, which can be detrimental during developm...
Targeting Rac1 for the prevention of atherosclerosis among U.S. Veterans with inflammatory bowel disease [0.03%]
针对炎症性肠病美国退伍军人动脉粥样硬化的Rac1靶向防治研究
S Scott Sutton,Joseph Magagnoli,Tammy H Cummings et al.
S Scott Sutton et al.
Evidence suggests that Ras-related C3 botulinum toxin substrate 1 (Rac1) might be a target in atherosclerotic disease (AD). We hypothesize that due to their ability to inhibit Rac1, thiopurines are associated with a lower risk of AD. We fit...
Regulation of Leukaemia Associated Rho GEF (LARG/ARHGEF12) [0.03%]
leukemia相关Rho交换因子(LARG/ARHGEF12)的调节
Neda Z Ghanem,Michelle L Matter,Joe W Ramos
Neda Z Ghanem
The Ras homologous (Rho) protein family of GTPases (RhoA, RhoB and RhoC) are the members of the Ras superfamily and regulate cellular processes such as cell migration, proliferation, polarization, adhesion, gene transcription and cytoskelet...