Cristina Uribe-Alvarez,Jonathan Chernoff
Cristina Uribe-Alvarez
RAC1 is a small 21 kDa RHO GTPase that plays a pivotal role in regulating actin cytoskeletal dynamics and cell growth. Alterations in the activity of RAC1 are implicated in a range of diseases, including cancer. Increased RAC1 activity, due...
The structure of KRASG12C bound to divarasib highlights features of potent switch-II pocket engagement [0.03%]
与divarasib结合的KRASG12C结构揭示了有效开关-II袋参与的特征
Micah C Fernando,Gregory B Craven,Kevan M Shokat
Micah C Fernando
KRAS is the most frequently mutated oncogene in human cancer. In multiple types of cancer, a missense mutation at codon 12 substitutes a glycine for a cysteine, causing hyperactivation of the GTPase and enhanced MAPK signalling. Recent drug...
Small GTPase Rac promotes hyphal formation and microconidiogenesis in Trichophyton rubrum [0.03%]
小GTP酶Rac促进红色表皮癣菌的菌丝形成和微分生孢子生成
Masaki Ishii,Shinya Ohata
Masaki Ishii
Morphogenesis plays a pivotal role in the infection process of Trichophyton rubrum, a primary aetiological agent of dermatophytosis that inhabits superficial human tissues. T. rubrum proliferates by extending filamentous structures, or hyph...
To stay in shape and keep moving: MLL emerges as a new transcriptional regulator of Rho GTPases [0.03%]
保持体形和继续运动：MLL 成为Rho GTP酶的新转录调节因子
Akash Chinchole,Shreyta Gupta,Shweta Tyagi
Akash Chinchole
RhoA, Rac1 and CDC42 are small G proteins that play a crucial role in regulating various cellular processes, such as the formation of actin cytoskeleton, cell shape and cell migration. Our recent results suggest that MLL is responsible for ...
Serine phosphorylation of the RhoGEF Trio stabilizes endothelial cell-cell junctions [0.03%]
丝氨酸磷酸化稳定内皮细胞间的连接蛋白Rho交换因子Trio
Anna E Daniel,Werner J van der Meer,Lynn Wester et al.
Anna E Daniel et al.
The RhoGEF Trio is a large multi-domain protein and an activator of the small GTPases Rac1, RhoG, and RhoA. Although Trio has been implicated in many cellular mechanisms like leukocyte transendothelial migration, cell-cell junction stabilit...
Rab6-mediated retrograde trafficking from the Golgi: the trouble with tubules [0.03%]
Rab6介导的从高尔基体返回转运：囊泡还是管状小泡？
Lucy G Dornan,Jeremy C Simpson
Lucy G Dornan
Next year marks one-quarter of a century since the discovery of the so-called COPI-independent pathway, which operates between the Golgi apparatus and the endoplasmic reticulum (ER) in eukaryotic cells. Unlike almost all other intracellular...
ACKnowledging the role of the Activated-Cdc42 associated kinase (ACK) in regulating protein stability in cancer [0.03%]
激活的Cdc42相关激酶（ACK）在癌症中调控蛋白质稳定性的作用
Samantha Hodder,Millie Fox,Ana Masara Binti Ahmad Mokhtar et al.
Samantha Hodder et al.
Activated Cdc42-associated kinase (ACK), a non-receptor tyrosine kinase, is an effector for the small GTPase Cdc42. ACK is emerging as an important component of the cancer landscape and thus, a promising target for the treatment of many mal...
PI3K Functions Downstream of Cdc42 to Drive Cancer phenotypes in a Melanoma Cell Line [0.03%]
PI3K介导的Cdc42下游信号通路驱动黑色素瘤细胞系恶性表型的研究
Rosemary Poku,Felix Amissah,Jamie K Alan
Rosemary Poku
Rho proteins are part of the Ras superfamily, which function to modulate cytoskeletal dynamics including cell adhesion and motility. Recently, an activating mutation in Cdc42, a Rho family GTPase, was found in a patient sample of melanoma. ...
C D Lawson,K Hornigold,D Pan et al.
C D Lawson et al.
P-Rex1 and P-Rex2 are guanine-nucleotide exchange factors (GEFs) that activate Rac small GTPases in response to the stimulation of G protein-coupled receptors and phosphoinositide 3-kinase. P-Rex Rac-GEFs regulate the morphology, adhesion a...
A New Crosslinking Assay to Study Guanine Nucleotide Binding in the Gtr Heterodimer of S. cerevisiae [0.03%]
一种新的交联测定法，用于研究S. cerevisiae的Gtr异二聚体中的鸟嘌呤核苷酸结合
Dylan D Doxsey,Kristen Veinotte,Kuang Shen
Dylan D Doxsey
The mechanistic target of rapamycin (mTOR) complex is responsible for coordinating nutrient availability with eukaryotic cell growth. Amino acid signals are transmitted towards mTOR via the Rag/Gtr heterodimers. Due to the obligatory hetero...