Efficient A·T-to-C·G Base Editing via Adenine Transversion Editors [0.03%]
高效A·T到C·G碱基编辑器通过腺嘌呤互变异构编辑实现
Muhammad Arslan Mahmood
Muhammad Arslan Mahmood
Generating A-to-C transversions to correct defective alleles or introduce novel alleles has posed significant challenges. However, two recent studies focusing on adenine transversions have achieved successful A-to-C transversions in mouse e...
A Novel Method for Human Adipose-Derived Stem Cell Isolation and Cryopreservation [0.03%]
一种新型的人体脂肪来源干细胞分离及冻存方法
Young-Cheol Lim,Jung-Il Jung,In-Kee Hong
Young-Cheol Lim
Adipose-derived stem cells (ADSCs) are isolated from abundant adipose tissue and have the capacity to differentiate into multiple cell lineages. ADSCs have raised big interest in therapeutic applications in regenerative medicine and demonst...
Unleashing Ascl1: Exploring Cross-Lineage Potential in Reprogramming and Regenerative Frontiers [0.03%]
释放Ascl1：探究重编程和再生前沿中的跨谱系潜力
Camila Vazquez Echegaray
Camila Vazquez Echegaray
In the era of stem cell research and regenerative medicine, understanding the regulatory networks that drive cellular reprogramming is fundamental. The study entitled "Cross-lineage potential of Ascl1 uncovered by comparing diverse reprogra...
Reprogramming Stars #13: Establishing Connections with Cellular Reprogramming-An Interview with Dr. Daniella Rylander Ottosson [0.03%]
从细胞重编程建立联系——对Daniella Rylander Ottosson博士的采访（十三）星重生系列文章之十三：从细胞重编程建立联系——对Daniella Rylander Ottosson 博士的访谈
Daniella Rylander Ottosson,Carlos-Filipe Pereira
Daniella Rylander Ottosson
Tongtong Guo,Qi Wei
Tongtong Guo
The reprogramming of terminally differentiated cells over the past few years has become important for induced pluripotent stem cells (iPSCs) in the field of regenerative medicine and disease drug modeling. At the same time, iPSCs have also ...
Fuping Wang,Runting Li,Limeng Zhang et al.
Fuping Wang et al.
With the discovery and development of somatic cell nuclear transfer, cell fusion, and induced pluripotent stem cells, cell transdifferentiation research has presented unique advantages and stimulated a heated discussion worldwide. Cell tran...
Transcriptomic Heterogeneity of Human Mesenchymal Stem Cells Derived from Bone Marrow, Dental Pulp, Adipose Tissue, and Umbilical Cord [0.03%]
来源于骨髓、牙髓、脂肪组织和脐带的间充质干细胞转录组异质性分析
Xiaoxiao Zhu,Xinchen Xu,Mengyuan Shen et al.
Xiaoxiao Zhu et al.
Compared with mesenchymal stem cells (MSCs) obtained from other tissue sources, those derived from umbilical cord (UC) tissue exhibit numerous advantages and vast potential for therapeutic applications. However, MSCs from different tissue s...
Human Induced Pluripotent Stem Cell-Derived Pericytes as Scalable and Editable Source to Study Direct Lineage Reprogramming Into Induced Neurons [0.03%]
人诱导多能干细胞来源的周细胞作为研究直接重编程为诱导神经元的可扩展和可编辑来源
Radhika Menon,Linda Petrucci,Benjamin Lohrer et al.
Radhika Menon et al.
Studying human somatic cell-to-neuron conversion using primary brain-derived cells as starting cell source is hampered by limitations and variations in human biopsy material. Thus, delineating the molecular variables that allow changing the...
A Safer Path to Cellular Rejuvenation: Endogenous Oct4 Activation via CRISPR/dCas9 in Progeria Mouse Models [0.03%]
安全的细胞 rejuvenation途径：通过CRISPR/dcas9在progeria小鼠模型中激活内源性Oct4
Di Hu,Enora Le Borgne,Rico Meinl
Di Hu
A recent study in Aging Cell showed that transcriptional activation of endogenous Oct4 using the CRISPR/dCas9 activator system is sufficient for cellular rejuvenation and extending the lifespan of a progeria mouse model. Although transient ...
Reprogramming Stars #12: At the Heart of In Vivo Reprogramming- An Interview with Dr. Li Qian [0.03%]
重编星星第12期：体内重新编程的核心——对李茜博士的访谈
Li Qian,Carlos-Filipe Pereira
Li Qian