Amniotic fluid cells are more efficiently reprogrammed to pluripotency than adult cells [0.03%]
羊膜上皮细胞重编程为诱导多能干细胞的效率远高于成体细胞
Elisa Galende,Ioannis Karakikes,Lisa Edelmann et al.
Elisa Galende et al.
Recently, cultured human adult skin cells were reprogrammed to induced pluripotent stem (iPS) cells, which have characteristics similar to human embryonic stem (hES) cells. Patient-derived iPS cells offer genetic and immunologic advantages ...
Deciphering the mesodermal potency of porcine skin-derived progenitors (SKP) by microarray analysis [0.03%]
微阵列分析解读皮肤源前体细胞的胚内中胚层分化潜能
Ming-Tao Zhao,Kristin M Whitworth,Xia Zhang et al.
Ming-Tao Zhao et al.
Skin stem cells have an essential role in maintaining tissue homeostasis by dynamically replenishing those constantly lost during tissue turnover or following injury. Multipotent skin derived progenitors (SKP) can generate both neural and m...
Generation of mouse embryonic stem cell lines from zona-free nuclear transfer embryos [0.03%]
无 zona 壳膜的卵子直接注射胚胎核移植及产生小鼠胚胎干细胞系
Julianna Kobolak,Szilard Bodo,Ruttachuk Rungsiwiwut et al.
Julianna Kobolak et al.
Pluripotent stem cells would have great potential in cell therapies and drug development when genetically matched with the patient; thus, histocompatible cells could be used in transplantation therapy or as a source of patient-specific cell...
Increasing histone acetylation of cloned embryos, but not donor cells, by sodium butyrate improves their in vitro development in pigs [0.03%]
氯化丁酸改善克隆胚胎体外发育而不能改善供核细胞的组蛋白乙酰化水平
Ziban Chandra Das,Mukesh Kumar Gupta,Sang Jun Uhm et al.
Ziban Chandra Das et al.
Previous studies have demonstrated that increased histone acetylation in donor cells or cloned embryos, by applying a histone deacetylase inhibitor (HDACi) such as trichostatin A (TSA), significantly enhances their developmental competence....
Pre- and postimplantation development of swine-cloned embryos derived from fibroblasts and bone marrow cells after inhibition of histone deacetylases [0.03%]
组蛋白去乙酰化酶抑制条件下体细胞和骨髓细胞克隆猪胚胎的早期和晚期发育研究
Mario A Martinez-Diaz,Limei Che,Marcelo Albornoz et al.
Mario A Martinez-Diaz et al.
The present study assessed changes in epigenetic markers and pre- and postimplantation development in somatic cell nuclear transfer (SCNT) porcine embryos after treatment with the inhibitor of histone deacetylases (HDACi), Trichostatin A (T...
Histone deacetylase inhibitors improve in vitro and in vivo developmental competence of somatic cell nuclear transfer porcine embryos [0.03%]
组蛋白去乙酰化酶抑制剂改善体细胞克隆猪胚胎的发育潜能
Jianguo Zhao,Yanhong Hao,Jason W Ross et al.
Jianguo Zhao et al.
Faulty epigenetic reprogramming of somatic nuclei is likely to be a major cause of low success observed in all mammals produced through somatic cell nuclear transfer (SCNT). It has been demonstrated that the developmental competence of SCNT...
Valproic acid enhances in vitro development and Oct-3/4 expression of miniature pig somatic cell nuclear transfer embryos [0.03%]
丙戊酸钠改善猪体细胞克隆胚胎的发育潜能并诱导重编程相关的基因表达
Kazuchika Miyoshi,Hironori Mori,Yamato Mizobe et al.
Kazuchika Miyoshi et al.
The present study was carried out to examine the effects of valproic acid (VPA), a histone deacetylase inhibitor, on in vitro development of miniature pig somatic cell nuclear transfer (SCNT) embryos and on expression of a mouse Oct-3/4 pro...
Preferential loss of porcine chromosomes in reprogrammed interspecies cell hybrids [0.03%]
猪间种重编程细胞杂交体中染色体的优先丢失规律研究
Monika Nowak-Imialek,Wilfried A Kues,Cornelia Rudolph et al.
Monika Nowak-Imialek et al.
Fusion of terminally differentiated somatic cells with pluripotent embryonic stem cells has been proposed as model for reprogramming the somatic cell genome, and may contribute to our understanding of the underlying mechanisms of this epige...
Rapid elimination of the histone variant MacroH2A from somatic cell heterochromatin after nuclear transfer [0.03%]
体细胞异染色质中的组蛋白变体MacroH2A在核移植后的快速消除
Ching-Chien Chang,Shaorong Gao,Li-Ying Sung et al.
Ching-Chien Chang et al.
Oocytes contain a maternal store of the histone variant MacroH2A, which is eliminated from zygotes shortly after fertilization. Preimplantation embryos then execute three cell divisions without MacroH2A before the onset of embryonic MacroH2...
DNA methylation patterns reflect epigenetic reprogramming in bovine embryos [0.03%]
DNA甲基化模式反映了牛胚胎的表观遗传重编程现象
Heiner Niemann,Joseph W Carnwath,Doris Herrmann et al.
Heiner Niemann et al.
To understand the epigenetic alterations associated with assisted reproduction technology (ART) and the reprogramming of gene expression that follows somatic cell nuclear transfer (SCNT), we screened a panel of 41 amplicons representing 25 ...