Sustained Vision Recovery by OSK Gene Therapy in a Mouse Model of Glaucoma [0.03%]
利用OSK基因治疗在青光眼小鼠模型中实现持续的视觉恢复
Margarete M Karg,Yuancheng Ryan Lu,Nasrin Refaian et al.
Margarete M Karg et al.
Glaucoma, a chronic neurodegenerative disease, is a leading cause of age-related blindness worldwide and characterized by the progressive loss of retinal ganglion cells (RGCs) and their axons. Previously, we developed a novel epigenetic rej...
Low-Intensity Nanosecond Pulsed Electric Field Accelerates Osteogenic Transformation of Human Dermal Fibroblasts by Enhancing Cell Pluripotency [0.03%]
低强度纳秒脉冲电场通过提高细胞多能性促进人类皮肤成纤维细胞向骨细胞转分化
Jingtian Lai,Zewei Wang,Haiying Zhou et al.
Jingtian Lai et al.
Autologous human fibroblasts have the potential to differentiate into the osteogenic lineage under specific conditions and can be utilized for bone regeneration. However, their efficiency is currently unsatisfactory. Recently, low-intensity...
Allogeneic Mesenchymal Stem Cells After In Vivo Transplantation: A Review [0.03%]
异体移植后间充质干细胞的体内命运及机制研究进展
Derek B Asserson
Derek B Asserson
Autologous mesenchymal stem cells (MSCs) are ideal for tissue regeneration because of their ability to circumvent host rejection, but their procurement and processing present logistical and time-sensitive challenges. Allogeneic MSCs provide...
Microscopic Analysis of Cell Fate Alteration Induced by Cell Fusion [0.03%]
融合诱发的细胞命运转变的微观解析研究英文题目翻译：细胞融合诱导的细胞命运改变的显微分析
Taisei Kumazaki,Chinatsu Yonekawa,Tomomi Tsubouchi
Taisei Kumazaki
In mammals, differentiated cells generally do not de-differentiate nor undergo cell fate alterations. However, they can be experimentally guided toward a different lineage. Cell fusion involving two different cell types has long been used t...
Reprogramming Cell Identity: Past Lessons, Challenges, and Future Directions [0.03%]
重编程细胞身份：以往的教训、挑战与未来方向
José C R Silva
José C R Silva
Reprogramming is traditionally defined as the fate conversion of a cell to a stage of increased developmental potential. In its broader meaning, the reprogramming term is also applied to all forms of cell fate conversion that do not follow ...
Induced Pluripotent Stem Cell-Derived Chimeric Antigen Receptor T Cells: The Intersection of Stem Cells and Immunotherapy [0.03%]
诱导多能干细胞衍生的嵌合抗原受体T细胞：干性与免疫治疗的融合
Mohammad Reza Lahimchi,Faezeh Maroufi,Amirhosein Maali
Mohammad Reza Lahimchi
Chimeric antigen receptor (CAR) T cell therapy is a promising cell-based immunotherapy applicable to various cancers. High cost of production, immune rejection, heterogeneity of cell product, limited cell source, limited expandability, and ...
Hepatitis B Virus x Protein Increases Cellular OCT3/4 and MYC and Facilitates Cellular Reprogramming [0.03%]
乙型肝炎病毒X蛋白可增加细胞OCT3/4和MYC并促进细胞重编程
Madhusudana Girija Sanal,Sarita Gupta,Rahul Saha et al.
Madhusudana Girija Sanal et al.
Hepatitis B virus x (HBx) is a multifunctional protein coded by the Hepatitis B virus that is involved in various cellular processes such as proliferation, cell survival/apoptosis, and histone methylation. HBx was reported to be associated ...
Anna Smajdor,Adrian Villalba
Anna Smajdor
Louise Brown's birth in 1978 heralded a new era not just in reproductive technology, but in the relationship between science, cells, and society. For the first time, human embryos could be created, selected, studied, manipulated, frozen, al...
SIRT6 Knockdown in Buffalo Fetal Fibroblasts Exacerbates Premature Senescence Caused by DNA and Telomere Damage [0.03%]
DNA和端粒损伤引起的水牛胎儿成纤维细胞衰老模型中SIRT6敲低加剧了衰老表型
Jingyuan Liang,Jiayu Cui,Juanru Cheng et al.
Jingyuan Liang et al.
As a gene with antiaging functions, sirtuin6 (SIRT6) belonging to the sirtuin family plays a vital role in DNA repair, telomerase function, and cellular senescence, as well as maintains epigenomic stability and promotes longevity. However, ...
Proteomic Analysis and Reprogramming Potential of the Porcine Intra-Ooplasmic Nanovesicles [0.03%]
猪卵浆纳米囊泡的蛋白质组分析及重编程潜能研究
Islam M Saadeldin,Seonggyu Bang,Abdulkadir Y Maigoro et al.
Islam M Saadeldin et al.
Oocytes contain reprogramming machinery that can transform somatic cells into totipotent cells. In this study, we aimed to isolate and characterize nanovesicles from mature porcine oocytes and described them for the first time as "intra-oop...