Feline bone marrow-derived mesenchymal stem cells express several pluripotent and neural markers and easily turn into neural-like cells by manipulation with chromatin modifying agents and neural inducing factors [0.03%]
猫骨髓来源的间充质干细胞表达多种多能和神经标志物并可由染色质修饰剂和神经诱导因子的操纵轻易地转化为类似神经细胞
Zhiying Zhang,Dennis J Maiman,Shekar N Kurpad et al.
Zhiying Zhang et al.
Recent studies suggest that cellular therapies that utilize mesenchymal stem cells (MSCs), especially ones that have been neurally induced (NI), may provide a functional benefit in a wide range of neurological disorders. Recently, we develo...
Inhibition of fibroblast differentiation of muscle-derived stem cells in cell implantation treatment of stress urinary incontinence [0.03%]
肌肉源性干细胞种植治疗压力性尿失禁细胞分化纤维化抑制研究
Yanzhou Wang,Huicheng Xu,Xiaofang Liu et al.
Yanzhou Wang et al.
The aim of this study was to investigate the effects of transforming growth factor-β1 (TGF-β1) stimulation and the blocking of the TGF-β1/Smad3 signaling pathway by vector-mediated Smad3 shRNA on muscle-derived stem cells (MDSCs) in cell...
Toward transgene-free induced pluripotent stem cells: lessons from transdifferentiation studies [0.03%]
迈向无转基因诱导多能干细胞：转分化的研究启示
Shawn J Chua,Robert F Casper,Ian M Rogers
Shawn J Chua
Abstract Regenerative medicine has received much attention over the years due to its clinical and commercial potential. The excitement around regenerative medicine waxes and wanes as new discoveries add to its foundation but are not immedia...
DNA methylation in peripheral blood cells of pigs cloned by somatic cell nuclear transfer [0.03%]
体细胞核移植克隆猪外周血细胞的DNA甲基化分析
Fei Gao,Shengting Li,Lin Lin et al.
Fei Gao et al.
To date, the genome-wide DNA methylation status of cloned pigs has not been investigated. Due to the relatively low success rate of pig cloning by somatic cell nuclear transfer, a better understanding of the epigenetic reprogramming and the...
Effect of cytoplasmic volume on developmental competence of buffalo (Bubalus bubalis) embryos produced through hand-made cloning [0.03%]
buffalo（Bubalus bubalis）胚胎的手工克隆及细胞质体积对其发育能力的影响
Sudeepta K Panda,Aman George,Ambika P Saha et al.
Sudeepta K Panda et al.
This study examined the effects of cytoplasmic volume on the developmental competence of hand-made cloned buffalo embryos. Two different cell types, that is, buffalo fetal fibroblast (BFF) and buffalo embryonic stem (ES) cell-like cells wer...
LIF and FGF cooperatively support stemness of rabbit embryonic stem cells derived from parthenogenetically activated embryos [0.03%]
卵裂球诱导的全能性因子协同维持兔孤雌胚胎干细胞的多能性
Ya-Chen Hsieh,Payungsuk Intawicha,Kun-Hsiung Lee et al.
Ya-Chen Hsieh et al.
We investigated the individual and combined effects of leukemia inhibitory factor (LIF) and basic fibroblast growth factor 2 (bFGF2) on the derivation and maintenance of rabbit embryonic stem cell lines isolated from parthenogenetic activat...
Isolation and in vitro characterization of putative porcine embryonic stem cells from cloned embryos treated with trichostatin A [0.03%]
猪克隆胚胎衍生的组蛋白去乙酰化酶抑制剂特异性胚胎干细胞样的细胞系的分离和鉴定
Ivan Vassiliev,Svetlana Vassilieva,Kam P Truong et al.
Ivan Vassiliev et al.
We report here the establishment and characterization of putative porcine embryonic stem cell (ESC) lines derived from somatic cell nuclear transfer embryos (NT-ESCs). These cells had a similar morphology to that described previously by us ...
Scriptaid corrects gene expression of a few aberrantly reprogrammed transcripts in nuclear transfer pig blastocyst stage embryos [0.03%]
-scriptaid纠正克隆猪囊胚阶段异常重编程的几个转录本的基因表达
Kristin M Whitworth,Jiangou Zhao,Lee D Spate et al.
Kristin M Whitworth et al.
Nuclear transfer efficiency in the pig is low and is thought to be caused by inadequate nuclear reprogramming. The objective of this study was to identify differentially represented transcripts in pig in vivo derived (BLIVV), in vitro ferti...
Production of cloned and transgenic embryos using buffalo (Bubalus bubalis) embryonic stem cell-like cells isolated from in vitro fertilized and cloned blastocysts [0.03%]
利用体外受精和克隆囊胚分离水牛(Bubalus bubalis)胚胎干细胞样细胞并建立嵌合体动物模型
Aman George,Ruchi Sharma,Karn P Singh et al.
Aman George et al.
Here, we report the isolation and characterization of embryonic stem (ES) cell-like cells from cloned blastocysts, generated using fibroblasts derived from an adult buffalo (BAF). These nuclear transfer embryonic stem cell-like cells (NT-ES...
Comparative Study
Cellular reprogramming. 2011 Jun;13(3):263-72. DOI:10.1089/cell.2010.0094 2011
The effects of 5-aza-2'- deoxycytidine and trichostatin A on gene expression and DNA methylation status in cloned bovine blastocysts [0.03%]
5-氮杂胞苷和曲古菌素A对牛克隆囊胚基因表达及DNA甲基化状态的影响
Yongsheng Wang,Jianmin Su,Lijun Wang et al.
Yongsheng Wang et al.
We previously found that treatment of both donor cells and early cloned embryos with combination of 5-aza-2'-deoxycytidine (5-aza-dC) and trichostatin A (TSA) significantly improve the in vitro and full-term development of nuclear transfer ...