Dental Pulp Stem Cell-Derived Exosomes Promote Sciatic Nerve Regeneration via Optimizing Schwann Cell Function [0.03%]
牙髓干细胞来源的外泌体通过优化施万细胞功能促进坐骨神经再生
Ying Chai,Yuemin Liu,Zhiyang Liu et al.
Ying Chai et al.
Repair strategies for injured peripheral nerve have achieved great progresses in recent years. However, the clinical outcomes remain unsatisfactory. Recent studies have found that exosomes secreted by dental pulp stem cells (DPSC-exos) have...
High Expression of ZFP42 Improves Early Development of Pig Embryos Produced by Handmade Cloning [0.03%]
ZFP42高表达改善猪手工克隆胚胎的早期发育
Tianbin Liu,Yan Wu,Lin Li et al.
Tianbin Liu et al.
Handmade Cloning (HMC) is a pivotal technique for cloning pig embryos. Despite its significance, the low efficiency of this method hampers its widespread application. Although numerous factors and signaling pathways influencing embryo devel...
Testosterone Supplementation Promotes Estrogen Synthesis of Buffalo Cumulus Cells Surrounding In Vitro-Matured Oocytes [0.03%]
睾酮补充促进体外成熟水牛卵母细胞周围颗粒细胞雌激素合成
Jun Zhang,Junming Sun,Meizhen Ou et al.
Jun Zhang et al.
Cumulus cells (CCs) synthesize estrogens that are essential for follicular development. However, the effects of androgen on estrogen production in buffalo CCs remain unknown. In the present study, the impacts of testosterone on estrogen syn...
Luis G Palma,Anna Bigas
Luis G Palma
Creating hematopoietic stem cells (HSCs) capable of multilineage engraft while possessing the ability to self-renew stands as a pivotal achievement within the field of regenerative medicine. However, achieving the generation of these cells ...
Gene Therapy-Mediated Partial Reprogramming Extends Lifespan and Reverses Age-Related Changes in Aged Mice [0.03%]
基因疗法介导的部分重编程延长了老年小鼠的寿命并逆转了衰老相关的变化
Carolina Cano Macip,Rokib Hasan,Victoria Hoznek et al.
Carolina Cano Macip et al.
Aging is a complex progression of changes best characterized as the chronic dysregulation of cellular processes leading to deteriorated tissue and organ function. Although aging cannot currently be prevented, its impact on life- and healths...
Reprogramming Stars #14: Fast-Forwarding Cellular Reprogramming- An Interview with Dr. Mark Kotter [0.03%]
重新编程星星#14：细胞重新编程的快进 - 对Mark Kotter博士的采访
Mark R Kotter,Carlos-Filipe Pereira
Mark R Kotter
Partial Reprogramming as a Method for Regenerating Neural Tissues in Aged Organisms [0.03%]
部分重编程作为老化有机体神经组织再生的方法
Ali Saber Sichani,Somayeh Khoddam,Shayan Shakeri et al.
Ali Saber Sichani et al.
Aging causes numerous age-related diseases, leading the human species to death. Nevertheless, rejuvenating strategies based on cell epigenetic modifications are a possible approach to counteract disease progression while getting old. Cell r...
Induction of Transient Morula-Like Cells in Mice Through STAT3 Activation [0.03%]
通过激活STAT3诱导小鼠的瞬时桑葚胚样细胞
Celia Fernandez-Rial,Miguel Fidalgo
Celia Fernandez-Rial
Developing in vitro cell models that faithfully replicate the molecular and functional traits of cells from the earliest stages of mammalian development presents a significant challenge. The strategic induction of signal transducer and acti...
Cloned Foal Born from Postmortem-Obtained Ear Sample Refrigerated for 5 Days Before Fibroblast Isolation and Decontamination of the Infected Monolayer Culture [0.03%]
从死后获得的耳部样本培养纤维细胞并净化感染的单层细胞培养物而克隆出小马驹
Jenin V Cortez,Kylie Hardwicke,Christopher G Grupen et al.
Jenin V Cortez et al.
A 6-year-old mare, a valuable polo horse, died of complications following postcolic surgery. To preserve its genetics, ear skin samples were collected immediately after death and stored in an equine embryo transfer medium at 4°C for 5 days...
Marcelo Tigre Moura
Marcelo Tigre Moura
Deep transfer learning improves the inference of gene regulatory networks in human cells, reveals disease-associated genes, and identifies network-based druggable targets in human heart disease. ...