Isolation and characterization of SSEA3(+) stem cells derived from goat skin fibroblasts [0.03%]
来源于山羊皮肤成纤维细胞的SSEA3(+)干细胞的分离和鉴定
Zhongcai Yang,Jun Liu,Hongliang Liu et al.
Zhongcai Yang et al.
Novel stem cells expressing stage-specific embryonic antigen 3 (SSEA-3) reside among human dermal fibroblasts and are known as multilineage-differentiating stress-enduring (Muse) cells. They enhance the generation efficiency of induced plur...
Human induced pluripotent stem cells as a tool to model a form of Leber congenital amaurosis [0.03%]
人诱导多能干细胞在莱伯氏先天性黑蒙建模中的应用研究
Céline Lustremant,Walter Habeler,Alexandra Plancheron et al.
Céline Lustremant et al.
Our purpose was to investigate genes and molecular mechanisms involved in patients with Leber congenital amaurosis (LCA) and to model this type of LCA for drug screening. Fibroblasts from two unrelated clinically identified patients with a ...
Generation of neural cells from DM1 induced pluripotent stem cells as cellular model for the study of central nervous system neuropathogenesis [0.03%]
DM1诱导多能干细胞生成神经细胞作为中枢神经系统神经发病学研究的细胞模型
Guangbin Xia,Katherine E Santostefano,Marianne Goodwin et al.
Guangbin Xia et al.
Dystrophia myotonica type 1 (DM1) is an autosomal dominant multisystem disorder. The pathogenesis of central nervous system (CNS) involvement is poorly understood. Disease-specific induced pluripotent stem cell (iPSC) lines would provide an...
Clinical Trial
Cellular reprogramming. 2013 Apr;15(2):166-77. DOI:10.1089/cell.2012.0086 2013
Oct4 promoter activity in stem cells obtained through somatic reprogramming [0.03%]
外胚层细胞重编程而来的干细胞中Oct4启动子活性分析
Winfried H Krueger,Borko Tanasijevic,Carol Norris et al.
Winfried H Krueger et al.
Multiple methods exist that can reprogram differentiated cells to a pluripotent state similar to that of embryonic stem cells (ESCs). These include somatic cell nuclear transfer (SCNT), fusion-mediated reprogramming (FMR) of somatic cells w...
Aaron Schindeler,Mille Kolind,David G Little
Aaron Schindeler
Epithelial-to-mesenchymal transition (EMT) and endothelial-to-mesenchymal transition (EndMT) describe complex changes in progenitor lineage, cell morphology, and gene expression. Stimulated by environmental cues, these cellular transitions ...
Effect of the time interval between fusion and activation on epigenetic reprogramming and development of bovine somatic cell nuclear transfer embryos [0.03%]
体细胞核移植胚胎中融合与激活的时间间隔对表观重编程及发育的影响研究
Jun Liu,Yongsheng Wang,Jianmin Su et al.
Jun Liu et al.
Previous studies have shown that the time interval between fusion and activation (FA interval) play an important role in nuclear remodeling and in vitro development of somatic cell nuclear transfer (SCNT) embryos. However, the effects of FA...
Identifying candidate oocyte reprogramming factors using cross-species global transcriptional analysis [0.03%]
利用跨物种转录组分析识别卵母细胞重编程因子候选者
Jason P Awe,James A Byrne
Jason P Awe
There is mounting evidence to suggest that the epigenetic reprogramming capacity of the oocyte is superior to that of the current factor-based reprogramming approaches and that some factor-reprogrammed induced pluripotent stem cells (iPSCs)...
Developmental potential of cloned goat embryos from an SSEA3(+) subpopulation of skin fibroblasts [0.03%]
从皮肤成纤维细胞SSEA3（+）亚群中克隆的山羊胚胎的发育潜能
Jun Liu,Zhongcai Yang,Mingning Qiu et al.
Jun Liu et al.
Previous studies have demonstrated that skin stem cells expressing the pluripotency marker stage-specific embryonic antigen 3 (SSEA3) are easier to reprogram into induced pluripotent stem cells (iPSCs) than skin fibroblasts. Furthermore, it...
Direct reprogramming of fibroblasts to myocytes via bacterial injection of MyoD protein [0.03%]
通过细菌注射肌生成因子(MyoD蛋白)直接重编程成纤维细胞为肌细胞
Candace Bichsel,Dennis Neeld,Takashi Hamazaki et al.
Candace Bichsel et al.
Forced exogenous gene expression has been well characterized as an effective method for directing both cellular differentiation and dedifferentiation. However, transgene expression is not amenable for therapeutic application due to potentia...
Positive correlation of Oct4 and ABCG2 to chemotherapeutic resistance in CD90(+)CD133(+) liver cancer stem cells [0.03%]
OCT4和ABCG2在CD90⁺CD133⁺肝癌干细胞化疗抗性中的正相关性研究
Qian Jia,Xiaoli Zhang,Tao Deng et al.
Qian Jia et al.
Liver cancer is one of the most common tumors worldwide and drug resistance is a major obstacle to successful therapy. The growing data show that cancer stem cells (CSCs), a rare subpopulation of cancer cells, might be an important mechanis...