Rewinding the Tape to Identify Intrinsic Determinants of Reprogramming Potential [0.03%]
利用表观遗传重编程确定固有决定因素
Kate E Galloway
Kate E Galloway
Via retrospective isolation of clones using Rewind, Jain et al. identified primed states of cells that reprogram to induced pluripotent stem cells. Examining clones, they find that cells retain memory of over several rounds of cell division...
Marcelo Tigre Moura
Marcelo Tigre Moura
Cloning by somatic cell nuclear transfer (SCNT) remained challenging for Rhesus monkeys, mostly due to its low efficiency and neonatal death. Genome-scale analyses revealed that monkey SCNT embryos displayed widespread DNA methylation and t...
Reprogramming Stars #16: Reprogramming, from Cells to Embryos-An Interview with Dr. José Silva [0.03%]
重编星星第16篇：从细胞到胚胎的再编程——对Jose Silva博士的采访
José C R Silva,Carlos-Filipe Pereira
José C R Silva
Reprogramming Stars #16: Reprogramming, from Cells to Embryos-An Interview with Dr. José Silva [0.03%]
从细胞到胚胎的重新编程——对Jose Silva博士的采访（一六）
José C R Silva,Carlos-Filipe Pereira
José C R Silva
Molecular Prospective on Malignant Transformation of Mesenchymal Stem Cells: An Issue in Cell Therapy [0.03%]
间充质干细胞恶性转化的分子视点——细胞治疗中需要关注的问题
Maryam Kaviani,Saeede Soleimanian,Somayeh Keshtkar et al.
Maryam Kaviani et al.
Mesenchymal stem cell (MSCs) therapy, as a rapidly developing area of medicine, holds great promise for the treatment of a variety of medical conditions. MSCs are multipotent stem cells that can be isolated from various tissues and could se...
Highly Defined Induced Pluripotent Stem Cell Lines Mimic Donor Red Blood Cell Antigen Profiles for Therapeutic and Diagnostic Use [0.03%]
具有高度定义的诱导多能干细胞系模仿供体红细胞抗原谱型用于治疗和诊断使用
Lucas Ferioli Catelli,Péricles Natan Mendes da Costa,Felipe Augusto Rós et al.
Lucas Ferioli Catelli et al.
Our group generated two induced pluripotent stem cell (iPSC) lines for in vitro red blood cell (RBC) production from blood donors with extensively known erythrocyte antigen profiles. One line was intended to give rise to RBCs for transfusio...
Revitalizing the Aging Immune System Through Selective Stem Cell Targeting [0.03%]
通过选择性干细胞靶向疗法重塑衰老的免疫系统
Anna Konturek-Ciesla,David Bryder
Anna Konturek-Ciesla
The interplay between aging and immune system deterioration presents a formidable challenge to human health, especially in the context of a globally aging population. Aging is associated with a decline in the body's ability to combat infect...
Marlene J Oesterle,Nicholas D Leigh
Marlene J Oesterle
Cellular senescence is a state in which cells enter cell cycle arrest. However, senescent cells have the ability to secrete signaling molecules such as chemokines, cytokines, and growth factors. This secretory activity is an important featu...
Dynamic Roles of Signaling Pathways in Maintaining Pluripotency of Mouse and Human Embryonic Stem Cells [0.03%]
信号转导通路在维持小鼠和人胚胎干细胞多能性中的动态作用
Anagha Oke,Sonal M Manohar
Anagha Oke
Culturing of mouse and human embryonic stem cells (ESCs) in vitro was a major breakthrough in the field of stem cell biology. These models gained popularity very soon mainly due to their pluripotency. Evidently, the ESCs of mouse and human ...
Reprogramming Stars #15: Colliding Cellular Reprogramming Paths- An Interview with Dr. Stefan Stricker [0.03%]
重编星星第15期：碰撞的细胞重编程路径——对斯特凡·施特里克博士的采访
Stefan H Stricker,Carlos-Filipe Pereira
Stefan H Stricker