Hepatocyte-ductal transdifferentiation is mediated by reciprocal repression of SOX9 and C/EBPα [0.03%]
SOX9和C/EBPα互斥抑制介导肝细胞胆管转分化
Kathy E O&#x;Neill,Shifaan Thowfeequ,Wan-Chun Li et al.
Kathy E O&#x;Neill et al.
Primary hepatocytes rapidly dedifferentiate when cultured in vitro. We have studied the mechanism of hepatocyte dedifferentiation by using two culture media: one that maintains hepatocytes in a differentiated state and another that allows d...
Sox2 is a potent inhibitor of osteogenic and adipogenic differentiation in human mesenchymal stem cells [0.03%]
SOX2通过抑制人源间充质干细胞的软骨分化促进其自我更新能力
Veronika Schönitzer,Roman Wirtz,Veronika Ulrich et al.
Veronika Schönitzer et al.
Human mesenchymal stem cells (hMSCs) are a promising target for cell-based bone regeneration. However, their application for clinical use is limited because hMSCs lose their ability for cell division and differentiation during longer in vit...
Sodium butyrate efficiently converts fully reprogrammed induced pluripotent stem cells from mouse partially reprogrammed cells [0.03%]
丁酸钠可高效地将小鼠部分重编程细胞诱导为完全具备全能性的诱导多能干细胞
Seok-Jin Kang,Young-Il Park,ByungJae So et al.
Seok-Jin Kang et al.
Partially reprogrammed cells [preinduced pluripotent stem cells (pre-iPSCs)] commonly stall at epigenetic barriers, and this is one of the major failures in the reprogramming process. These cells can be converted to the fully reprogrammed s...
5-azacytidine promotes the transdifferentiation of cardiac cells to skeletal myocytes [0.03%]
5-氮杂胞苷促进心肌细胞向骨骼肌细胞的转分化
Keerat Kaur,Jinpu Yang,Carol A Eisenberg et al.
Keerat Kaur et al.
The DNA methylation inhibitor 5-azacytidine is widely used to stimulate the cardiac differentiation of stem cells. However, 5-azacytidine has long been employed as a tool for stimulating skeletal myogenesis. Yet, it is unclear whether the a...
Nonviral minicircle generation of induced pluripotent stem cells compatible with production of chimeric chickens [0.03%]
非病毒minicircle生成的诱导多能干细胞适合产生嵌合鸡
Ping Yu,Yangqing Lu,Brian J Jordan et al.
Ping Yu et al.
Chickens are vitally important in numerous countries as a primary food source and a major component of economic development. Efforts have been made to produce transgenic birds through pluripotent stem cell [primordial germ cells and embryon...
Generation of induced pluripotent stem cells from hair follicle bulge neural crest stem cells [0.03%]
从毛囊bulge神经嵴干细胞中生成诱导多能干细胞
Ming-San Ma,Marcin Czepiel,Tina Krause et al.
Ming-San Ma et al.
Induced pluripotent stem cells (iPSCs) are promising candidates for the study of disease models as well as for tissue engineering purposes. Part of a strategy to develop safe reprogramming technique is reducing the number of exogenous repro...
The potential of dental stem cells differentiating into neurogenic cell lineage after cultivation in different modes in vitro [0.03%]
不同培养模式下体外诱导牙源干细胞向神经元分化潜能的实验研究
Chao Yang,Liang Sun,Xinghan Li et al.
Chao Yang et al.
Trauma or degenerative diseases of the central nervous system (CNS) cause the loss of neurons or glial cells. Stem cell transplantation has become a vital strategy for CNS regeneration. It is necessary to effectively induce nonneurogenic st...
Chika Koike,Kaixuan Zhou,Yuji Takeda et al.
Chika Koike et al.
The amnion membrane is developed from embryo-derived cells, and amniotic cells have been shown to exhibit multidifferentiation potential. These cells represent a desirable source for stem cells for a variety of reasons. However, to date ver...
Clinical Trial
Cellular reprogramming. 2014 Aug;16(4):298-305. DOI:10.1089/cell.2013.0090 2014
Murine embryonic fibroblast cell lines differentiate into three mesenchymal lineages to different extents: new models to investigate differentiation processes [0.03%]
小鼠胚胎成纤维细胞株可不同程度地分化为三种间充质谱系：研究分化的新型模式细胞系
Khaled Dastagir,Kerstin Reimers,Andrea Lazaridis et al.
Khaled Dastagir et al.
Various diseases, injuries, and congenital abnormalities may result in degeneration and loss of organs and tissues. Recently, tissue engineering has offered new treatment options for these common, severe, and costly problems in human health...
Psammaplin a improves development and quality of somatic cell nuclear transfer mouse embryos [0.03%]
PSAMPLIN A改善体细胞克隆小鼠早期胚胎发育质量
Anna Mallol,Josep Santaló,Elena Ibáñez
Anna Mallol
Faulty reprogramming of the donor somatic nucleus to a totipotent embryonic state by the recipient oocyte is a major obstacle for cloning success. Accordingly, treatment of cloned embryos with epigenetic modifiers, such as histone deacetyla...