Osteogenic Differentiation of Human and Ovine Bone Marrow Stromal Cells in response to β-Glycerophosphate and Monosodium Phosphate [0.03%]
β-甘油磷酸和一水合磷酸钠诱导人和绵羊骨髓基质细胞向成骨方向分化的比较研究
Marta Bottagisio,Arianna B Lovati,Silvia Lopa et al.
Marta Bottagisio et al.
Bone defects are severe burdens in clinics, and thus cell therapy offers an alternative strategy exploiting the features of bone marrow stromal cells (BMSCs). Sheep are a suitable orthopedic preclinical model for similarities with humans. T...
The Histone Acetyltransferase MOF Promotes Induces Generation of Pluripotent Stem Cells [0.03%]
组蛋白乙酰化酶MOF促进诱导多能干细胞的生成
Xupeng Mu,Shaohua Yan,Changhao Fu et al.
Xupeng Mu et al.
Histone modification plays an important role in maintaining pluripotency and self-renewal of embryonic stem cells (ESCs). The histone acetyltransferase MOF is a key regulator of ESCs; however, the role of MOF in the process of reprogramming...
Generation of Xeroderma Pigmentosum-A Patient-Derived Induced Pluripotent Stem Cell Line for Use As Future Disease Model [0.03%]
用于未来疾病建模的着色性干皮病患者来源的诱导多能干细胞系的建立
Hiroe Ohnishi,Takashi Kawasaki,Tomonori Deguchi et al.
Hiroe Ohnishi et al.
Xeroderma pigmentosum group A (XP-A) is a genetic disorder in which there is an abnormality in nucleotide excision repair that causes hypersensitivity to sunlight and multiple skin cancers. The development of central and peripheral neurolog...
Isolation, Culture, Differentiation, and Nuclear Reprogramming of Mongolian Sheep Fetal Bone Marrow-Derived Mesenchymal Stem Cells [0.03%]
蒙古绵羊骨髓间充质干细胞的分离、培养、诱导分化及核编程研究
Xiaohu Su,Yu Ling,Chunxia Liu et al.
Xiaohu Su et al.
We have characterized the differentiation potentiality and the developmental potential of cloned embryos of fetal bone marrow mesenchymal stem cells (BMSCs) isolated from Mongolian sheep. BMSCs were harvested by centrifuging after the expla...
Runx1 and Runx3 Are Downstream Effectors of Nanog in Promoting Osteogenic Differentiation of the Mouse Mesenchymal Cell Line C3H10T1/2 [0.03%]
Runx1和Runx3是在Nanog促进小鼠间充质细胞系C3H10T1/2成骨分化中的下游效应因子
Tadahito Saito,Shinsuke Ohba,Fumiko Yano et al.
Tadahito Saito et al.
Previously, we reported that the transcription factor Nanog, which maintains the self-renewal of embryonic stem cells (ESCs), promotes the osteogenic differentiation of the mouse mesenchymal cell line C3H10T1/2 through a genome reprogrammin...
Conversion of Adipose Tissue-Derived Mesenchymal Stem Cells to Neural Stem Cell-Like Cells by a Single Transcription Factor, Sox2 [0.03%]
单个转录因子Sox2将脂肪组织衍生的间充质干细胞转化为类似神经干细胞的细胞
Yiren Qin,Chikai Zhou,Nianhong Wang et al.
Yiren Qin et al.
Adipose tissue is an attractive source of easily accessible adult candidate cells for regenerative medicine. Adipose tissue-derived mesenchymal stem cells (ADSCs) have multipotency and strong proliferation and differentiation capabilities i...
Generation of Induced Pluripotent Stem Cells from Bovine Epithelial Cells and Partial Redirection Toward a Mammary Phenotype In Vitro [0.03%]
来自牛上皮细胞的诱导多能干细胞的生成及部分在体外向乳腺表型转化
Diego Cravero,Eugenio Martignani,Silvia Miretti et al.
Diego Cravero et al.
In contrast to adult stem cells, induced pluripotent stem cells (iPSCs) can be grown robustly in vitro and differentiated into virtually any tissue, thus providing an attractive alternative for biomedical applications. Although iPSC technol...
Epigenetic Modification of Cloned Embryos Improves Nanog Reprogramming in Pigs [0.03%]
克隆胚胎的表观遗传修饰可改善猪体内的Nanog重编程过程
Yanjun Huan,Hongmei Wang,Zhanfeng Wu et al.
Yanjun Huan et al.
Incomplete reprogramming of pluripotent genes in cloned embryos is associated with low cloning efficiency. Epigenetic modification agents have been shown to enhance the developmental competence of cloned embryos; however, the effect of the ...
Stem Cell-Derived Bioactive Materials Accelerate Development of Porcine In Vitro-Fertilized Embryos [0.03%]
干细胞衍生的生物活性物质加速猪体外受精胚胎的发育进程
Seung-Eun Lee,Jeremiah Ji-Man Moon,Eun-Young Kim et al.
Seung-Eun Lee et al.
Stem cells show the capability to proliferate in an undifferentiated state with long-term self-renewal, which gives the cells advantages for use as bioactive material (BM) for embryo culture in vitro. The objective of this experiment was to...
Application Of Small Molecules Favoring Naïve Pluripotency during Human Embryonic Stem Cell Derivation [0.03%]
在人胚胎干细胞衍生过程中应用倾向于原始多能性的小分子
Margot Van der Jeught,Jasin Taelman,Galbha Duggal et al.
Margot Van der Jeught et al.
In mice, inhibition of both the fibroblast growth factor (FGF) mitogen-activated protein kinase kinase/extracellular-signal regulated kinase (MEK/Erk) and the Wnt signaling inhibitor glycogen synthase-3β (GSK3β) enables the derivation of ...