Reprogramming Stars #17: Breaking Down the Barriers of Direct Reprogramming Using a Model Organism-An Interview with Dr. Baris Tursun [0.03%]
从模式生物视角探究直接重编程壁垒——访巴里斯·图尔松博士
Baris Tursun,Mariana Lopes,Carlos-Filipe Pereira
Baris Tursun
Bidirectional Prime Editing: Combining Precision with Versatility for Genome Editing [0.03%]
双向精准基因编辑技术：融合了高效与通用性的新型Prime Editor系统
Mahmood S Choudhery,Taqdees Arif,Ruhma Mahmood
Mahmood S Choudhery
Genome editing techniques have potential to revolutionize the field of life sciences. Several limitations associated with traditional gene editing techniques have been resolved with the development of prime editors that precisely edit the D...
Protective Effect and Molecular Mechanism of Mesenchymal Stem Cell-Derived Extracellular Vesicles in Diabetic Foot Ulcers [0.03%]
间充质干细胞来源的外泌体在糖尿病足溃疡中保护作用及分子机制研究
Jian Zhao,Yan Gu,Peng Hou
Jian Zhao
This study explores the protective mechanism of mesenchymal stem cell-derived extracellular vesicles (MSC-EVs) in diabetic foot ulcer (DFU). Human umbilical cord MSCs (HucMSCs) were identified via osteogenesis and adipogenic differentiation...
Reprogramming Stars #19: Upgrading Cell Fate Conversions with Engineered Reprogramming Factors-An Interview with Dr. Ralf Jauch [0.03%]
重编星星第19篇：利用工程再造因子升级细胞命运转换——对Ralf Jauch博士的访谈
Ralf Jauch,Mariana Lopes,Carlos-Filipe Pereira
Ralf Jauch
Reprogramming of Expanded Cord Blood-Derived CD34+ Cells from Umbilical Cord-Mesenchymal Stromal Cell Co-Culture to Generate Human-Induced Pluripotent Stem Cells [0.03%]
人诱导多能干细胞的生成：来自脐带间充质基质细胞共培养的扩增脐血CD34阳性细胞的再编程
Fatin Fazrina Roslan,Yuexin Yu,Mengmeng Wang et al.
Fatin Fazrina Roslan et al.
Cord blood (CB) is widely stored as a source of hematopoietic stem cells for potential future use, though its application for autologous purposes remains limited. Repurposing CB into human-induced pluripotent stem cells (hiPSCs) can broaden...
Transplantation of Human Induced Pluripotent Stem Cell-Derived Airway Epithelia at Different Induction Stages into Nude Rat [0.03%]
人诱导多能干细胞不同分化阶段呼吸道上皮细胞裸鼠移植实验
Keisuke Mizuno,Hiroe Ohnishi,Yo Kishimoto et al.
Keisuke Mizuno et al.
Tracheal reconstruction is necessary in patients with large tracheal defects. Previously, artificial tracheae made of polypropylene and collagen sponge have been used clinically by our group. As a basic research aimed at promoting epithelia...
Riccardo Piussi,Andrea Ditadi
Riccardo Piussi
The successful generation of long-term engrafting hematopoietic stem cells (HSCs) from human-induced pluripotent stem cells (hiPSCs) has long been sought to revolutionize treatments for hematological disorders, eliminating reliance on donor...
Deciphering the Sertoli Cell Signaling Pathway with Protein-Protein Interaction, Single-Cell Sequencing, and Gene Ontology [0.03%]
基于蛋白质互作、单细胞测序和基因本体的曲细精管支持细胞信号转导路径解析研究
Danial Hashemi Karoii,Gohar Javadzadeh,Hossein Azizi et al.
Danial Hashemi Karoii et al.
Spermatogenesis constitutes a complex and intricate cascade of differentiation, indispensable for the male reproductive competence. The intercellular communication conduits of Sertoli cells (SCs) are pivotal in orchestrating this cascade en...
Reprogramming Stars #18: Engineering Cell Fates and Preventing Disease by Repressing Unwanted Plasticity-An Interview with Dr. Moritz Mall [0.03%]
揭秘细胞重编程：抑制非生理性可塑性以防治疾病——对莫里茨·马尔博士的专访
Moritz Mall,Mariana Lopes,Carlos-Filipe Pereira
Moritz Mall
A New Frontier in Tumor Eradication: Harnessing In Vivo Cellular Reprogramming for Durable Cancer Immunotherapy [0.03%]
肿瘤根除的新前沿：利用体内细胞重编程进行持久性癌症免疫治疗
Constantinos Chronis
Constantinos Chronis
Tumors evade immune detection by downregulating antigen presentation and hindering immune responses. Type 1 conventional dendritic cells (cDC1s) are vital in stimulating cytotoxic T cells against tumors. Ascic et al. are now demonstrating t...